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Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis.
J Clin Endocrinol Metab
December 2014
Divisions of Pediatric Endocrinology and Diabetes (D.N., P.G.B., K.I., M.F.), the Duke Molecular Physiology Institute (J.B., M.M., R.S., O.I., M.F.), the Division of General Pediatrics (D.D., S.A.), Duke University Medical Center, Durham, North Carolina 27710, and Advanced Analytics Division, SAS Institute Inc (M. B.), Cary, North Carolina 27513.
Objective: Obesity and insulin resistance (IR) predispose to type 2 diabetes mellitus. Yet only half of obese adolescents have IR and far fewer progress to type 2 diabetes mellitus. We hypothesized that amino acid and fatty acid metabolites may serve as biomarkers or determinants of IR in obese teens.
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