6 results match your criteria: "SACYL-University of Salamanca-CSIC[Affiliation]"
The untapped potential of 3D virtualization using high resolution scanner-based and photogrammetry technologies for bone bank digital modeling.
Comput Biol Med
December 2024
BTELab. Fundación de Investigación del Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, Pabellón B Planta 4, Valencia, 46014, Spain; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA. Electronic address:
Article Synopsis
- This study explores how three non-contact 3D scanning technologies—structured light scanning (SLG), laser scanning (LAS), and photogrammetry (PHG)—can enhance tissue banking for bone transplantation by providing precise measurements while minimizing contamination risks.
- It evaluates the accuracy of these technologies using cranial caps and highlights that SLG is the most effective method for tissue banking due to its balance of accuracy, cost, and usability, despite all methods slightly underestimating specimen volume.
- Additionally, while PHG performed well in capturing cranial cap details, it lacked dimensional accuracy, showing potential for future smart healthcare solutions and virtual tissue bank development.
Recurrent Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.
Cancers (Basel)
August 2022
Institute of Biomedical Research of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, 37007 Salamanca, Spain.
The incidence of early-onset colorectal cancer (EOCRC; age younger than 50 years) has been progressively increasing over the last decades globally, with causes unexplained. A distinct molecular feature of EOCRC is that compared with cases of late-onset colorectal cancer, in EOCRC cases, there is a higher incidence of ( somatic deletions. However, the mechanisms of in early-onset colorectal carcinogenesis are currently unknown.
View Article and Find Full Text PDFOncogenic driver mutations predict outcome in a cohort of head and neck squamous cell carcinoma (HNSCC) patients within a clinical trial.
Sci Rep
October 2020
Medical Oncology Service, University Hospital of Salamanca-IBSAL, 37007, Salamanca, Spain.
234 diagnostic formalin-fixed paraffin-embedded (FFPE) blocks from homogeneously treated patients with locally advanced head and neck squamous cell carcinoma (HNSCC) within a multicentre phase III clinical trial were characterised. The mutational spectrum was examined by next generation sequencing in the 26 most frequent oncogenic drivers in cancer and correlated with treatment response and survival. Human papillomavirus (HPV) status was measured by p16INK4a immunohistochemistry in oropharyngeal tumours.
View Article and Find Full Text PDFGenetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.
Cancers (Basel)
April 2019
Medical Oncology Service, University Hospital of Salamanca-IBSAL, 37007 Salamanca, Spain.
Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis).
View Article and Find Full Text PDFAnalysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma.
Sci Rep
July 2017
Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain.
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity.
View Article and Find Full Text PDFEpidermal growth factor receptor (EGFR) pathway polymorphisms as predictive markers of cetuximab toxicity in locally advanced head and neck squamous cell carcinoma (HNSCC) in a Spanish population.
Oral Oncol
December 2016
Medical Oncology Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, Spain; Molecular Medicine Unit-IBSAL, Department of Medicine, University of Salamanca, Spain. Electronic address:
Objectives: To examine the relationship between polymorphisms of the epidermal growth factor receptor (EGFR) pathway and toxicity in head and neck squamous cell carcinoma (HNSCC) patients treated with cetuximab.
Material And Methods: Multicenter, retrospective, observational pilot study which included 110 patients with histologically-confirmed human papillomavirus (HPV) negative HNSCC in locally advanced stages (III-IVA-B) and who were treated with chemotherapy and radiotherapy plus cetuximab between 2003 and 2013. Genetic analyses for single nucleotide polymorphisms (SNP) in genes EGFR, CCDN1, FCGR2A, FCGR3A and KRAS-LCS6 were performed though available allelic discrimination assay and/or polymerase chain reaction-restriction fragment length polymorphism methods.