High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana.

Objectives: We assessed HIV-1 drug resistance profiles among people living with HIV (PLWH) with detectable viral load (VL) and on dolutegravir-based antiretroviral therapy (ART) in Botswana.

Methods: The study utilised available 100 residual HIV-1 VL samples from unique PLWH in Francistown who had viraemia at-least 6 months after initiating ART in Botswana's national ART program from November 2023 to January 2024. Viraemia was categorized as low-level viraemia (LLV) (VL: 200-999 copies/mL) or virologic failure (VF) (VL ≥1000 copies/mL).

"There's a Little Bit of Tension There:" Perspectives of Mothers and Early Childhood Educators on Breastfeeding in Child Care Centers.

Objective: To explore mothers' and early childhood (EC) educators' experiences of breastfeeding/breast milk provision and breastfeeding support in child care centers (CCCs) in the United States (U.S.).

Rhinorrhea Recurrence After Posterior Nasal Nerve Cryoablation: A Multicenter Cohort Study.

Background: Posterior nasal nerve (PNN) cryoablation improves chronic rhinitis (CR) symptoms in 70-80% of cases, including clear thin rhinorrhea (CTR). This study's purpose was to determine time to and degree of CTR recurrence following cryoablation.

Methods: A multicenter retrospective cohort study was conducted on patients who underwent PNN cryoablation to treat CR-related CTR refractory to ipratropium bromide nasal spray (IBNS).

Effect of digital health applications with or without gamification on physical activity and cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials.

Background: Use of health applications (apps) to support healthy lifestyles has intensified. Different app features may support effectiveness, including gamification defined as the use of game elements in a non-game situation. Whether health apps with gamification can impact behaviour change and cardiometabolic risk factors remains unknown.

Unveiling the immunomodulator role of plasma oxidized lipids in SA-AKI progression: a CRRT perspective.

Background: Plasma oxidized lipids are intimately linked to immune regulation as bioactive mediators. However, it is not clear whether they are related to the progression of sepsis-associated acute kidney injury (SA-AKI) and the effect of continuous renal replacement therapy (CRRT). This study intends to explore the changes in certain oxidized lipid during CRRT treatment and their correlation with the immune microenvironment and prognosis by analyzing plasma oxidative lipidomics.

Post-treatment Recovery in Orbital Arteriovenous Fistulas: A Systematic Review.

Orbital arteriovenous fistulas (AVFs) are rare vascular malformations that can cause severe ocular complications. This review evaluates the effectiveness of treatment strategies, focusing on post-treatment recovery and recurrence. A systematic review was conducted using PubMed and Scopus with no date restrictions.

Body composition as a novel biomarker of recurrence risk in patients with triple-negative breast cancer.

Background and Hypothesis Triple-negative breast cancer (TNBC) patients are at increased risk for recurrence compared to other subtypes of breast cancer. Previous evidence showed that adiposity may contribute to worsened cancer control. Current measures of obesity, such as body-mass index (BMI), are poor surrogates of adiposity, while visceral-to-subcutaneous adiposity ratio (VSR), which can be measured from routine computed tomography (CT) imaging, is a direct adiposity measure.

Endostatin as a biomarker of systemic sclerosis: insights from a systematic review and meta-analysis.

Introduction: The critical role played by vascular dysfunction and ineffective angiogenesis in the pathophysiology of systemic sclerosis (SSc) suggests that circulating biomarkers reflecting these alterations may be useful in the clinical evaluation of this patient group. We sought to address this issue by conducting a systematic review and meta-analysis of studies investigating a such candidate biomarker, endostatin, an endogenous glycoprotein exerting anti-angiogenic effects, in SSc patients and healthy controls.

Methods: A literature search was conducted in the electronic databases Web of Science, PubMed, and Scopus from inception to 27 May 2024.

Potent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapy.

The search for effective anti-cancer therapies has led to the exploration of dual inhibition strategies targeting multiple key molecular pathways. In this study, we aimed to design a novel candidate capable of dual inhibition targeting both EGFR (Epidermal Growth Factor Receptor) and PARP-1 (poly(ADP-ribose)polymerase-1), two crucial proteins implicated in cancer progression and resistance mechanisms. Through molecular hybridization and structure-based drug design approaches, we synthesized a series of compounds based on spirooxindole with triazole scaffolds with the potential for dual EGFR and PARP-1 inhibition.

Remarkable utilization of quinazoline-based homosulfonamide for cytotoxic effects with triple kinase inhibition activities: cell cycle analysis and molecular docking profile.

We tested newly synthesized compounds 1-13 on 59 cancer cell lines and found that acylhydrazones 5, 6, 7, 9, and 12 showed the best cytotoxic activity. They stopped the mean growth percentage (MG%) by an average of 23.5, 55.

The effectiveness of unimodality organ preservation surgical vs organ preservation radiotherapy for early hypopharyngeal cancer: a systematic review protocol.

Objective: Our aim is to determine the comparative effectiveness of unimodality organ preservation surgery versus radiotherapy on oncological and functional outcomes in patients with early hypopharyngeal cancer.

Introduction: Early hypopharyngeal cancer is difficult to detect and therefore rarely diagnosed, as patients are often asymptomatic. Radiotherapy is considered the main treatment, although this modality has been compared to the previously used open surgical approach, which may not reflect current surgical options.

Self-Healing Oxidized Dextran/Sodium Alginate Hydrogel Dressing with Hemostatic Activity Speeds Up Wound Healing in Burn Injuries.

This study introduced a hydrogel dressing, termed SODex-gel, which was constructed by establishing Schiff base and hydrogen bonds with the precursors of oxidized dextran (ODex) and succinic dihydrazide (SD)-modified sodium alginate (SD--SA). Through comprehensive and studies, the adhesive properties, self-healing capabilities, hemostatic potential, and wound healing efficacy of the SODex-gel dressing were meticulously evaluated. The H NMR, FTIR, and TGA analyses confirmed the fabrication of the SODex-gel dressing and its constituent elements.

The Fundamentals of Care Framework in nursing education: a scoping review protocol.

Objective: This scoping review aims to identify and map the use of the Fundamentals of Care Framework in nursing education to provide insights into curriculum development that can benefit educators, health care professionals, and policy makers in educational contexts.

Introduction: The Fundamentals of Care Framework offers a comprehensive approach for conceptualizing and delivering high-quality, person-centered fundamental care. Use of the framework in education is shown to enhance critical thinking, establish a shared language for nursing care, and increase understanding of person-centered care.

Paramedic assessment of suspected or confirmed COVID-19 patients in the out-of-hospital environment: a scoping review protocol.

Objective: The objective of this review is to develop a comprehensive collection of information about the current processes for paramedics assessing and referring suspected or confirmed COVID-19 patients in the out-of-hospital environment.

Introduction: Patients with COVID-19 are frequently encountered by paramedics and ambulance service clinicians. Increased demand on ambulance services has resulted in many of these services developing alternative referral pathways to avoid unnecessary conveyance to emergency departments.

Mapping resilience and co-occurring theoretical constructs in nurses: a scoping review protocol.

Objective: The aim of this scoping review is to map the concept of resilience and its measurement along with co-occurring theoretical constructs within nursing research using the COVID-19 pandemic as a critical date range for the current evidence.

Introduction: Resilience has a wide variety of definitions in research literature and is often measured through its co-occurring theoretical constructs. Nurse resilience is a key element in interventions targeting nurse well-being and has been tied to burnout and mental health.

First Report of Postharvest Fruit Rot on Passion Fruit () caused by in the U.S.A.

The commercial production of passion fruit is geographically limited (California, Florida, and Hawaii), but the development of cold-tolerant varieties could expand it beyond warm-climate states (Stafne et.al. 2023).

A MACPF Protein OsCAD1 Balances Plant Growth and Immunity Through Regulating Salicylic Acid Homeostasis in Rice.

Unraveling the mechanisms behind plant growth and immunity contributes to effective crop improvement. Membrane attack complex/perforin (MACPF) domain proteins play vital roles in innate and adaptive immunity in vertebrates; however, their molecular functions in plants remain largely unexplored. Here, we isolated and characterized a rice mutant, Oryza sativa constitutively activated cell death 1 (oscad1), which exhibited a lesion mimic phenotype and growth inhibition with increased cell death, elevated ROS accumulation, and enhanced resistance to bacterial blight Xanthomonas oryzae pv.

Transcanalicular laser-assisted and external dacryocystorhinostomy anatomical and functional success in primary acquired nasolacrimal duct obstruction: systematic review and meta-analysis.

Background: Primary acquired nasolacrimal duct obstruction (PANDO) is a condition in which tear ducts are blocked, leading to epiphora and dacryocystitis. This systematic review and meta-analysis aimed to measure the ability of transcanalicular dacryocystorhinostomy (TC-DCR) as an alternative approach to PANDO compared to traditional external dacryocystorhinostomy (EX-DCR).

Methods: Our search included Embase, Medline, and the Cochrane Central Register of Controlled Trials (CENTRAL).

Genomic typing, antimicrobial resistance gene, virulence factor and plasmid replicon database for the important pathogenic bacteria Klebsiella pneumoniae.

Background: The infections of bacterial origin represent a significant problem to the public healthcare worldwide both in clinical and community settings. Recent decade was marked by limiting treatment options for bacterial infections due to growing antimicrobial resistance (AMR) acquired and transferred by various bacterial species, especially the ones causing healthcare-associated infections, which has become a dangerous issue noticed by the World Health Organization. Numerous reports shown that the spread of AMR is often driven by several species-specific lineages usually called the 'global clones of high risk'.

Impact of SGLT2 Inhibitors on Lipoproteins in Type 2 Diabetes.

Purpose Of Review: This article explores the cardiovascular effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM), with a particular focus on their impact on lipid profiles. As evidence grows of the cardiovascular benefits of SGLT2i beyond glucose control, it is essential to better understand their effects on lipoproteins and their impact on cardiovascular disease.

Recent Findings: SGLT2i have shown significant cardiovascular benefits in patients with type 2 diabetes mellitus, beyond their role in lowering blood glucose.

Biosorbent silver nanoparticles decorated coffee-ground waste composite for cleaning water and antimicrobial applications.

A sustainable biosorbent, silver nanoparticles-decorated coffee-ground waste (CWAg), was synthesized through a simple in-situ reduction method. CWAg is extensively characterized via SEM-EDX, PZC, FTIR, XRD, HR-TEM, and XPS analyses. The biosorbent was tested to remove chromium (Cr(VI)) and methylene blue (MB) from wastewater, and its antibacterial properties was evaluated.

Predicting largest expected aftershock ground motions using automated machine learning (AutoML)-based scheme.

Aftershocks can cause additional damage or even lead to the collapse of structures already weakened by a mainshock. Scarcity of in-situ recorded aftershock accelerograms heightens the need to develop synthetic aftershock ground motions. These synthesized motions are crucial for assessing the cumulative seismic demand on structures subjected to mainshock-aftershock sequences.

Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases.

Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities and evaluate functional capacity. This study investigates the relationship between sit-to-stand and stand-to-sit transitions and self-reported physical and mental fatigue in participants with Parkinson's, Huntington's, rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren's syndrome and inflammatory bowel disease.

Long-term effect of photodynamic therapy on choroidal vascularity index versus choroidal thickness as biomarkers for chronic central serous chorioretinopathy.

Objective: To investigate the long-term impact of half-fluence photodynamic therapy (PDT) on chorioretinal architecture in chronic central serous chorioretinopathy (cCSCR) through novel choroidal vascularity index (CVI) versus previously established subfoveal choroidal thickness (SFCT).

Methods: This post-hoc analysis included prospectively collected swept-source optical coherence tomography (SS-OCT) images of a total of 29 cCSCR and fellow eyes (FE), acquired before, one and 12 months after PDT. CVI, total choroidal area (TCA), luminal area (LA) and stromal area (SA) were calculated using validated binarization technique.