8 results match your criteria: "S.C.Z.); andMax Planck Institute for Molecular Plant Physiology[Affiliation]"
Value of Abbreviated Magnetic Resonance Sequence in Hepatocellular Carcinoma Screening: A Systematic Review and Meta-analysis.
Acad Radiol
January 2025
Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, PR China (J.H.L.); Department of Social medicine, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, PR China (J.H.L.); Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, Jiangsu 215123, PR China (J.H.L.).
Rationale And Objectives: To systematically review the diagnostic efficacy of abbreviated magnetic resonance imaging sequence (AMRI) screening for hepatocellular carcinoma (HCC).
Materials And Methods: Medline (via PubMed), EMbase, The Cochrane Library, Web of Science, CNKI, WanFang Data, and VIP databases were electronically searched to collect studies on the diagnostic efficacy of AMRI screening for HCC from inception to August 10th, 2024. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies using the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2), then, the meta-analysis with a bivariate mixed-effects regression model was performed by using Stata 14.
Target Trial Emulation Using Cohort Studies: Estimating the Effect of Antihypertensive Medication Initiation on Incident Dementia.
Epidemiology
January 2025
From the Department of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC.
Article Synopsis
- * The study analyzed data from three cohort studies to emulate trials examining the effects of starting antihypertensive medication on the incidence of dementia, while checking for potential biases in the methods used.
- * Results revealed inconsistent and imprecise links between antihypertensive medication initiation and dementia risk, raising concerns about residual confounding, which makes it difficult to draw solid conclusions about the relationship between these medications and dementia onset.
Treatment Outcomes and Definition Inconsistencies in High-Risk Unilateral Retinoblastoma.
Am J Ophthalmol
December 2024
From the Sheba Medical Center, The Goldschleger Eye Institute (M.A., I.D.), Sheba Medical Center, Ramat Gan, Israel; Faculty of Medicine, Tel Aviv University (M.A., A.B., I.D.), Tel Aviv, Israel; London School of Hygiene & Tropical Medicine (I.D., M. A.), London, UK. Electronic address:
Purpose: To compare the clinical outcomes of children with unilateral retinoblastoma (Rb) and high-risk histopathology features (HRHF) following upfront enucleation with/without adjuvant chemotherapy, and investigate cases locally considered non-HRHF but converted to a standardized HRHF definition.
Design: Retrospective multinational clinical cohort study.
Methods: Children with Rb who presented to 21 centers from 12 countries between 2011-2020, and underwent primary enucleation were recruited.
3D bioprinting of human neural tissues with functional connectivity.
Cell Stem Cell
February 2024
Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Department of Neurology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore, Singapore; GK Goh Centre for Neuroscience, Duke-NUS Medical School, Singapore, Singapore; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815. Electronic address:
Probing how human neural networks operate is hindered by the lack of reliable human neural tissues amenable to the dynamic functional assessment of neural circuits. We developed a 3D bioprinting platform to assemble tissues with defined human neural cell types in a desired dimension using a commercial bioprinter. The printed neuronal progenitors differentiate into neurons and form functional neural circuits within and between tissue layers with specificity within weeks, evidenced by the cortical-to-striatal projection, spontaneous synaptic currents, and synaptic response to neuronal excitation.
View Article and Find Full Text PDFLow- and High-Density Lipoprotein Cholesterol and Dementia Risk Over 17 Years of Follow-up Among Members of a Large Health Care Plan.
Neurology
November 2023
From the Department of Epidemiology and Biostatistics (E.L.F., S.C.Z., M.C., K.S., T.J.H., N.R., M.M.G.), University of California, San Francisco; Kaiser Permanente Division of Research (C.J., V.C., T.J.M., P.G., C.A.S.), Oakland; Institute for Human Genetics (A.O.-O., N.R.); Department of Clinical Pharmacy (A.O.-O.), University of California, San Francisco; Department of Public Health Sciences (R.A.W.), University of California, Davis; and Departments of Pediatrics and Medicine (R.M.K.), University of California, San Francisco. K.S. is currently affiliated with the VA Boston Healthcare System, MA. T.J.H. is currently affiliated with the Department of Epidemiology and Biostatistics, University of California, San Francisco, and the Institute for Human Genetics, University of California, San Francisco. P.G. is currently affiliated with the Kaiser Permanente Division of Research, Oakland, CA, and the Department of Epidemiology and Biostatistics, University of California, San Francisco. N.R. is currently affiliated with the Department of Epidemiology and Biostatistics, the Institute for Human Genetics, University of California, San Francisco, and the Kaiser Permanente Division of Research, Oakland, CA. M.M.G. is currently affiliated with the Department of Epidemiology, Boston University School of Public Health, MA.
Article Synopsis
- - This study examined the relationships between high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and the risk of developing dementia in older adults, suggesting complexities in these associations.
- - Researchers analyzed data from over 184,000 Kaiser Permanente members aged 55 and older, tracking dementia incidents from health records while controlling for various factors like demographic information and prior statin use.
- - Findings indicated that both low and high HDL-C levels corresponded to an increased risk of Alzheimer's disease-related dementia, while LDL-C levels alone showed no overall association, though statin use influenced LDL-C's risk effect.
A Randomized, Double-Blind, and Placebo-Controlled Trial of Chinese Herbal Medicine in the Treatment of Childhood Constipation.
Clin Transl Gastroenterol
May 2021
Departments of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, P.R. China.
Objectives: Management of constipation is still challenging in childhood. The pharmacological effect of XiaojiDaozhi Decoction, a prescription of Chinese Herbal Medicine (CHM), has been well described for the treatment of food and Qi stagnation which account for childhood constipation. However, the efficacy and safety of XiaojiDaozhi Decoction in childhood constipation remains unclear.
View Article and Find Full Text PDFGenetic Evidence That Chain Length and Branch Point Distributions Are Linked Determinants of Starch Granule Formation in Arabidopsis.
Plant Physiol
August 2014
Department of Biology, ETH Zurich, 8092 Zurich, Switzerland (B.P., K.-J.L., S.E., S.S., S.C.Z.); andMax Planck Institute for Molecular Plant Physiology, 14476 Potsdam, Germany (R.F., J.E.L.)
The major component of starch is the branched glucan amylopectin. Structural features of amylopectin, such as the branching pattern and the chain length distribution, are thought to be key factors that enable it to form semicrystalline starch granules. We varied both structural parameters by creating Arabidopsis (Arabidopsis thaliana) mutants lacking combinations of starch synthases (SSs) SS1, SS2, and SS3 (to vary chain lengths) and the debranching enzyme ISOAMYLASE1-ISOAMYLASE2 (ISA; to alter branching pattern).
View Article and Find Full Text PDFLongitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial.
J Am Heart Assoc
June 2014
Department of Pediatrics, University of Utah, Salt Lake City, UT (L.A.M.).
Background: We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure.
Methods And Results: We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=498). We determined length-for-age z score (LAZ) and weight-for-age z score (WAZ) at birth and age 3 years and change in WAZ over 4 clinically relevant time periods.