Synthesis and characterization of citric acid crosslinked carboxymethyl tamarind gum-polyvinyl alcohol hydrogel films.

The aim of present work was to synthesize and characterize carboxymethyl tamarind gum-polyvinyl alcohol (CMTG-PVA) hydrogel films using citric acid (CA) as a crosslinker. Hydrogel films were prepared by solvent casting technique. The films were evaluated for total carboxyl content (TCC), tensile strength, protein adsorption, permeability properties, hemocompatibility, swellability, moxifloxacin (MFX) loading and release, in-vivo wound healing activity and characterized using instrumental techniques.

Computational Study on the Effect of Thienyl π-Donor on the Optical Response of Nonclassical Oligo-Pyrazinothienothiadiazole Biradicaloids.

Computational analyses were performed on nitrogen-rich oligothiadizolothiophenes ( = 0-3) and their four π-donor-substituted derivatives ( = 0-3) to examine the optical response due to geometrical and electronic structural attributes in the longitudinal and transverse axes, respectively. Our results are understood in the context of greater conjugation in the longitudinal axis (via additional fused rings) and substitution of a thienyl π-donor in the transverse axis of the geometry of each derivative. On inspection of the frontier molecular orbitals, we found that the better electron-accepting ability with minimal sacrifice in the ionization potentials results from geometrical aspects in both longitudinal and transverse axes.

Synthesis, DFT analysis and in-vitro anti-cancer study of novel fused bicyclic pyranone isoxazoline derivatives of Goniodiol-diacetate-a natural product derivative.

Natural products, natural product-inspired molecules and natural product derivatives have contributed around 79% to the new chemotherapies against the most complex, deadly disease, cancer. In this study, a series of novel isoxazoline derivatives of Goniodiol diacetate (fused bicyclic pyranone isoxazoline derivatives)- a natural product derivative, were synthesized with quantitative yield as a single regioisomer by 1,3 - dipolar cycloaddition reaction with different aldoximes. The regiospecific product formed was confirmed by NOESY study and single-crystal X-ray diffraction.

Amelioration of diabetes and its complications by (L) P. Royen fruit peel extract and its fractions in alloxan and STZ-NA induced diabetes in Wistar rats.

Purpose: This study aims to evaluate the effects of (L) P. Royen fruit peel extract (EMZFP) and its fractions in ameliorating diabetes and its complications in alloxan and STZ-NA induced diabetes in Wistar rats.

Methods: Antidiabetic effects of EMZFP were assessed in alloxan (150 mg kg) induced diabetes in differently grouped rats (n=6).

Explorations of novel pyridine-pyrimidine hybrid phosphonate derivatives as aurora kinase inhibitors.

For developing novel therapeutic agents with good anticancer activities, a series of novel pyridine-pyrimidine hybrid phosphonate derivatives4(a-q) were synthesized by the Kabachnik-Fields method using CAN as catalyst. The compound 4o exhibited the most potent anticancer activity with an IC value of 13.62 μM, 17.

Recasting Ni-foam into NiF nanorod arrays a hydrothermal process for hydrogen evolution reaction application.

A promising electrode for hydrogen evolution reaction (HER) has been prepared via a reduction process to form NiF2 nanorod arrays directly grown on a 3D nickel foam. We reveal NiF2@Ni nanorod arrays for a stable hydrogen evolution reaction (HER) application. The computational analysis for H2O, OH and H and experimentally in aqueous KOH endow considerable shift in Fermi levels for Ni (111) unlike for NiF2 (110) on account of an effective coalition of p-orbitals of fluorine and d-orbitals of Ni in NiF2, NiF2 under pinning the reduced overpotential of 172 mV at 10 mA cm-2 compared to Ni (242 mV) in same electrolyte.

Enhanced catalytic activity of P1 protease by modulation with nanoactivator.

In the developing area of modern nanobiotechnology, the research is being focused on enhancement of catalytic performance in terms of efficiency and stability of enzymes to fulfill the industrial demand. In the context of this interdisciplinary era, we isolated and identified alkaline protease producer P1 by polyphasic approach and then followed one variable at a time approach to optimize protease production from P1. The modified components of fermentation medium (g/L) were wheat bran 10, soybean flour 10, yeast extract 5, NaCl 10, KHPO 1, KHPO 1 and MgSO·7HO 0.

Assessment of antidiabetic potential of peel extract and its fractions in experimental animals and characterisation of its bioactive compounds by HPTLC.

is a rich source of nutritional food with acclaimed therapeutic uses. Banana pulp has been reported to possess antidiabetic properties. The present study aimed to investigate antidiabetic potential of peels and its fractions along with diabetic complications.

FTIR studies, DFT calculations and time domain reflectometry studies on tetrahydrofuran - methanol binary solutions.

FTIR signature of neat tetrahydrofuran (THF), methanol (MeOH) and their binary solutions at various molefractions (0.8:0.2 (THF:MeOH), 0.

Correction: (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: and investigations.

[This corrects the article DOI: 10.18632/oncotarget.25717.

(Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: and investigations.

Plant originated drugs/formulations are extensively prescribed by the physicians as a complementary therapy for treating various human ailments including cancer. In this study leaves methanol extract was prepared and exposed to human breast cancer cell lines i.e.

Apoptotic impact on Brugia malayi by sulphonamido-quinoxaline: search for a novel therapeutic rationale.

Human lymphatic filariasis although not fatal but poses serious socioeconomic burden due to associated disability. This is reflected by the huge magnitude of the estimated disability-adjusted life years of about 5.09 million.

Dataset on analysis of dyeing property of natural dye from bark on different fabrics.

The natural dyes separated from plants are of gaining interest as substitutes for synthetic dyes in food and cosmetics is widely grown plant and used in the treatment of various diseases. This study was aimed to separate natural dye from bark and analysis of its dyeing property on different fabrics. In this investigation pharmacognostic study was carried out.

Aldose reductase inhibitory activity studies of THERACURMIN.

THERACURMIN a commercially available nano-dispersion of curcumin used to treat after effects of alcohol has been evaluated for in vitro ARI activity on Aldose reductase isolated from the bovine lens. As envisaged, the product displays better ARI activity with IC value of 3 μM. The observed ARI activity of THERACURMIN is of therapeutic significance as the limited bioavailability of curcumin limits its clinical use.

Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development.

Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive interest of researchers from pharmaceutical and chemical sciences and of drug regulatory agencies. The prominent reason of which is its ability to modify physicochemical properties of active pharmaceutical ingredients. During the development of the pharmaceutical product, formulators have to optimize the physicochemical properties of active pharmaceutical ingredients.

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit.

Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks.

Data on optimized production and characterization of alkaline proteases from newly isolated alkaliphiles from Lonar soda lake, India.

Alkaline proteases are one of the industrially important enzymes and generally preferred from alkaliphilic sources. Here we have provided the data on optimized production and characterization of alkaline proteases from five newly isolated and identified alkaliphiles from Lonar soda lake, India. The data provided for optimization of physicochemical parameters for maximum alkaline proteases production is based on OVAT (one variable at a time) approach.

Annona reticulata Linn. (Bullock's heart): Plant profile, phytochemistry and pharmacological properties.

From the beginning of human civilization plants and plant based chemicals are the most important sources of medicines. Phytochemical and different products obtained from plant are used as medicines, pharmaceuticals, cosmetics and food supplements. Annona reticulata Linn.

Crystal structure of N (1)-phenyl-N (4)-[(quinolin-2-yl)methyl-idene]benzene-1,4-di-amine.

In the title compound, C22H17N3, the dihedral angles between the central benzene ring and the terminal phenyl ring and quinoline ring system (r.m.s.

Therapeutic approaches to drug targets in atherosclerosis.

Non-communicable diseases such as cancer, atherosclerosis and diabetes are responsible for major social and health burden as millions of people are dying every year. Out of which, atherosclerosis is the leading cause of deaths worldwide. The lipid abnormality is one of the major modifiable risk factors for atherosclerosis.

Sequence analysis, structure and binding site prediction of Sigma 1 receptor protein by in silico method.

Sigma 1 Receptor is a subtype of opioid receptor that participates in membrane remodeling and cellular differentiation in the nervous system. Sigma1 Receptor protein with amino acid length ranging from 229 is widely distributed in the liver and moderately in the intestine, kidney, white pulp of the spleen, adrenal gland, brain, placenta and the lung. In this study, the three dimensional structure for sigma 1 receptor protein has been developed by in- silico analysis based on evolutionary trace analysis of 37 sigma proteins from different sources.

Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): a review.

More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents. Among them, Cordia dichotoma Forst., a small to moderate size plant of family Boragenaceae, commonly called bhokar, lasura, gonda, Indian cherry and shlesmataka.

Seroprevalence and Risk Factors for Hepatitis C Virus Infection among General Population in Central Region of Yemen.

Background. Hepatitis C virus (HCV) represents a major worldwide public health problem. Though several studies from Yemen have provided an estimate of the prevalence of this viral infection, there exist only few studies which reflect the status in the general population.

Multiple antibiotic resistance indexing of coliforms to identify high risk contamination sites in aquatic environment.

Bacteriological analysis of the water samples collected from upstream, midstream and downstream points along the bank of the river revealed high populations of Escherichia coli, Citrobacter freundii, Citrobacter diversus, Enterobacter aerogens and Klebsiella species. All these isolates were screened against eight antibiotics to determine the prevalence of multiple antibiotic resistance among isolates at different sites of the river. The study revealed that multiple antibiotic resistance was prominently seen in coliforms at downstream sites (Average multiple antibiotic resistance index, MAR Index = 0.

Hydrogen uptake capacity of C2H4Sc and its ions: a density functional study.

We report the gravimetric hydrogen uptake capacity of C(2)H(4)Sc complex and isoelectronic ions using Density Functional Theory. We predict that C(2)H(4)Sc(+) can bind maximum seven hydrogen molecules in dihydrogen form giving gravimetric uptake capacity of 16.2 wt %, larger by about 2 and 4 wt % than the neutral and anion, respectively.