An impact of treatment initiation timing on stroke outcome: bridging the time gap.

Aim Stroke treatment is a time-critical condition. Understanding the impact of timing and types of treatment on patient outcomes can help develop and optimize stroke management strategies. The study aimed to analyse the effect of different time intervals and mechanical thrombectomy methods on outcomes of stroke patients in Kazakhstan.

Evaluating the Effectiveness of a Modified Colorectal Cancer Screening Program in Almaty, Kazakhstan.

Objective: This study aimed to evaluate the effectiveness of a modified colorectal cancer (CRC) screening program, incorporating culturally tailored strategies to increase screening uptake and compliance, in Almaty, Kazakhstan.

Methods: A cross-sectional study was conducted in Almaty between 2019-2022, involving 5370 participants aged 50-70 from diverse settings. Participants were assigned to the main (modified method) and comparison (standard method) groups based on the parity of their ID number digits.

Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel.

Hydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent years, there has been a significant increase in the search for improved mechanical properties of hydrogels derived from natural products to extend their applications in various fields, and there are different methods to obtain strengthened hydrogels. Cationic guar gum has physicochemical properties that allow it to interact with other polymers and generate hydrogels.

Study of the Chemical Composition of Schrenk's Fruits and Leaves.

species are widely used in folk medicine in different countries of Asia and Europe, but not all species are studied in-depth. For instance, Schrenk, a plant which grows in Central Asia, Iran, and some parts of China, is little described in articles. Column and thin-layer chromatography methods were used to isolate biologically active substances.

Prevalence of chronic kidney disease in Kazakhstan: evidence from a national cross-sectional study.

To date, there have been no large-scale national studies of the prevalence of chronic kidney disease in Kazakhstan. It includes the research based on the analysis of the estimated glomerular filtration rate (eGFR). The aim of this study was to investigate the population prevalence of CKD and associated risk factors in Kazakhstan.

Regioselective Claisen-Schmidt Adduct of 2-Undecanone from Thunb as Insecticide/Repellent against and Repositioning Plant Fungicides against .

The U.S. Department of Agriculture (USDA) has established research programs to fight the phytopathogen and the invasive red imported fire ant, .

Epidemiological Analysis of HIV/AIDS in Kazakhstan During 2018-2020.

Background: The human immunodeficiency virus (HIV) is a severe threat to public health everywhere, including the Central Asian region and Kazakhstan. The aim of the study was to conduct an epidemiological analysis of newly diagnosed cases of HIV infection during 2018-2020.

Study Design: A case series study.

Screening for Breast, Cervical and Prostate Cancers in Kazakhstan: Key Factors and Psychological Aspects.

Objective: Screening is the main method for early detection and reduction of cancer mortality in all countries, including Central Asia and Kazakhstan. However, there is no official data on the awareness of the population about cancer screening in Kazakhstan. In addition, there were no studies on the psycho-emotional state of the patients during the screening procedure conducted yet.

Study of seroprevalence of SARS-CoV-2 in Kazakhstan.

This study aimed to analyse the seroprevalence of SARS-CoV-2 in Kazakhstan. This is a cross-sectional study of adult population in Kazakhstan for the period from October 2021 to May 2022. For the study, 6 720 people aged 18 to 69 were recruited (from 17 regions).

BRAT1-related disorders: phenotypic spectrum and phenotype-genotype correlations from 97 patients.

BRAT1 biallelic variants are associated with rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL), and neurodevelopmental disorder associating cerebellar atrophy with or without seizures syndrome (NEDCAS). To date, forty individuals have been reported in the literature. We collected clinical and molecular data from 57 additional cases allowing us to study a large cohort of 97 individuals and draw phenotype-genotype correlations.

Ultrastructural, Energy-Dispersive X-ray Spectroscopy, Chemical Study and LC-DAD-QToF Chemical Characterization of (L.) Ach.

The lichen (L.) Ach. has been used in traditional and modern medicines for its many biological properties such as immunological, immunomodulating, antioxidant, antimicrobial, and anti-inflammatory activities.

Chemical composition and cardiotropic activity of Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f.

Ethnopharmacological Relevance: Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.

Molecular Characterization of Some Species from Vegetables and Evaluation of Their Antimicrobial and Antibiotic Potency.

Numerous natural habitats, such as soil, air, fermented foods, and human stomachs, are home to different strains. Some strains have a distinctive predominance and are widely recognized among other microbial communities, as a result of their varied habitation and physiologically active metabolites. The present study collected vegetable products (potato, carrot, and tomato) from local markets in Almaty, Kazakhstan.

Study on Breast Cancer in Kazakhstan Using the Functional Time Series.

Aim: In Kazakhstan and Central Asia, breast cancer (BC) is the most common malignancy among women. However, no large-scale study on breast cancer using the functional time series approach has been carried out in Kazakhstan.

Methods: A functional assessment of the age-period-cohort model (APC) and the survival rate (period 2017-2021) was used in the retrospective study.

An economic impact of incorrect referrals for MRI and CT scans: A retrospective analysis.

Background And Aims: Up to date, no research on the economic efficacy of diagnostic modalities, such as magnetic resonance imaging (MRI) and computerized tomography (CT), has been done in Central Asia. The aim of this study was to analyse the inappropriate appointments of MRI and CT scanning procedures in Kazakhstan.

Methods: We used the imaging diagnostic reports and medical records from 9725 planned outpatient CT and MRI exams performed in two major hospitals in Almaty.

Assessment of the levels of interleukin-17 and interleukin-38 in thyroid-associated ophthalmopathy patients.

Purpose: The objective of the study was to analyse the levels of IL-17 and IL-38 in the samples of unstimulated tears, orbital adipose tissues, and sera of patients diagnosed with active forms of TAO. The correlation of the levels of IL-17 and IL-38 with clinical activity score (CAS) was scrutinized.

Methods: A study was conducted at the Kazakhstan Scientific Research Institute of Eye Diseases (Almaty city, Kazakhstan).

Evaluation of the sexual function of men in Kazakhstan during 2021-2022: A cross-sectional study.

Background And Aims: Assessing male sexual function is an important public health issue in every country. In Kazakhstan, there are currently no reliable statistics on male sexual function. The study aimed at the assessment of sexual function in men in Kazakhstan.

The Oxidative Drug Combination for Suppressing KRAS G12D Inducible Tumour Growth.

Background: Kirsten rat sarcoma (KRAS) protein is an essential contributor to the development of pancreatic ductal adenocarcinoma (PDAC). KRAS G12D and G12V mutant tumours are significant challenges in cancer therapy due to high resistance to the treatment.

Objective: To determine how effective is the ATO/D-VC combination in suppression of PDAC the mouse transgenic model.

Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Juz. Extracts.

species (Lamiaceae) have been used in traditional medicine as sedatives, antiseptics, carminatives, or expectorants. Despite their common applications in phytotherapy, there is still lack of evidence about the composition of their extracts and its impact on biological properties of the plants. The aim of this study was to evaluate the content of , a less studied species growing in Kazakhstan, using HPLC-ESI-QTOF-MS/MS instrumentation and to determine its antimicrobial, antioxidant, and cytotoxic activity together with inhibitory properties against tyrosinase and toxicity in erythrocyte lysis assay.

Study of Morphological Changes in Rat Liver Caused by Occlusion of Inferior Vena Cava.

Background/objectives: Up to date, there are no reports on animal survival rate and morphological changes in the liver caused by the impairment of blood outflow from the liver and its time dependence. Moreover, the impact of duration and degree of occlusion of inferior vena cava on pathological changes was not investigated yet. This study aimed at the assessment of the survival rate and morphological changes in the liver with varying degrees of occlusion of inferior vena cava.

The Recent Advances of Mobile Healthcare in Cardiology Practice.

Background: Digitalization of healthcare led to the optimization of monitoring, diagnostics, and treatment of the range of disorders. Taking into account recent situation with COVID-19 pandemics, digital technologies allowed to improve management of viral infections via remote monitoring and diagnostics of infected patients. Up to date, various mobile health applications (apps) have been proposed, including apps for the patients diagnosed with cardiovascular pathologies.

Immunomodulatory Effects of Plant Extracts from Schang. and L.

Medicines, their safety, effectiveness and quality are indispensable factors of national security, important on a global scale. The COVID-19 pandemic has once again emphasized the importance of improving the immune response of the body in the face of severe viral infections. Plants from the L.

Clinical classification of torus and effectiveness of two-layer bases in removable dentures.

Aim: To study and systematize the complaints of patients with removable prostheses, paying attention to the clinical manifestation of the torus and its sensitivity, and to determine the effectiveness of the use of two-layer bases in removable prosthetics.

Methods: In the clinic of orthopedic dentistry, 104 people were examined and received orthopedic treatment, including 37 patients in the comparison group. The main number of patients up to 55.