Results of 5-year follow-up study in patients with peripheral artery disease treated with PL-VEGF165 for intermittent claudication.

Background: The effective treatment of chronic lower limb ischemia is one of the most challenging issues confronting vascular surgeons. Current pharmacological therapies play an auxiliary role and cannot prevent disease progression, and new treatment methods are needed. In 2011, a plasmid VEGF65-gene therapy drug was approved in Russia for the treatment of chronic lower limb ischemia ( ClinicalTrials.

[Thyroid status peculiarities of elderly patients 5 years after operation depending on the volume of surgical intervention].

Long-term results of treatment of 180 patients operated 5 years ago for benign thyroid nodular pathology have been analyzed in the present paper, the results being analyzed depending on the volume of surgical intervention. The rate of postoperative hypothyrodism is lower in patients who had undergone limited thyroid resection, recurrent cases are more frequent, but they are not clinically significant and seldom require reoperation. It should also be noted that those patients have fewer cardiac complaints as the dose of hormone replacement therapy preparations is small.

[Effect of surgical treatment of thyroid nodules in older patients the likelihood of developing osteoporosis, the role of low levels of calcitonin].

In the article describes the role of deficiency of calcitonin, which originate after surgical operations on the thyroid gland, in headway of osteoporosis. Regarded significance such factors as age, level of parathyroid hormone, volume of the operational intervention in the development of osteoporosis. In elder people with thyroid nodular pathology bone metabolism is influenced by the amount of thyroid residue after resection.

[Characteristics of the different variants of the complex treatment of stomach ulcer].

The eradication therapy increases the speed of cicatrisation of ulcers in the gastroduodenal zones in infected patients. The best method to increase the efficiency of ulcer cicatrisation is reflex therapy for patients at the age of 22-50 years and laser therapy for older patients.

[Etiology and pathogenesis of peptic ulcer].

PU is a disease having many etiologies. The psychological constitutional type, low psychological adaptability and vegetative imbalance are the main causes in the pathogenesis of the disease. Chronic and acute stresses lead to vegetative tone disturbance, immunological imbalance, reduced resistance to HP, hypercoagulation and local blood flow impairment, causing hemorrhage and necrosis in the mucous coat of the gastroduodenal area.