7,706 results match your criteria: "Rwanda; Dana-Farber Cancer Institute[Affiliation]"

Podoconiosis is a non-infectious, neglected tropical disease caused by chronic barefoot contact with irritant volcanic soils. It typically presents with lower limb swelling, disfigurement, and chronic disability. Patients and their families experience stigma from their communities.

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Decolonizing global AI governance: assessment of the state of decolonized AI governance in Sub-Saharan Africa.

R Soc Open Sci

August 2024

Artificial Intelligence & Mathematical Modeling Lab (AIMM Lab), Dalla Lana School of Public Health, University of Toronto, 155 College St Room 500, Toronto, ON M5T 3M7.

Global artificial intelligence (AI) governance must prioritize equity, embrace a decolonial mindset, and provide the Global South countries the authority to spearhead solution creation. Decolonization is crucial for dismantling Western-centric cognitive frameworks and mitigating biases. Integrating a decolonial approach to AI governance involves recognizing persistent colonial repercussions, leading to biases in AI solutions and disparities in AI access based on gender, race, geography, income and societal factors.

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Implementation of an Intensive Surgical Simulation Week for Medical Students in Rwanda.

J Surg Res

October 2024

Program in Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Introduction: Simulation-based training often fails to meet the needs of low- and middle-income countries with limited access to high-cost models. We built on an existing surgical simulation curriculum for medical students in Rwanda and assessed students' experience.

Methods: Based on a contextual simulation-based education curriculum that was piloted in 2022, our team designed and delivered an intensive week-long surgical simulation course for medical students.

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The combination of low uptake of modern contraceptives, high rates of unintended pregnancies, and the pervasive HIV epidemic in Sub-Saharan Africa (SSA) poses a threat to maternal, newborn, and child health in the region. This study examined the prevalence, need, and demand satisfied by modern contraceptive methods for women who tested positive for HIV (both unmarried and married) in 10 countries in SSA. We used the Family Planning Estimation Tool (FPET) to generate national-level trends and projections from 1983 through 2030.

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Background: High-risk human papillomavirus (hrHPV) infection causes almost all cervical cancer. Women living with human immunodeficiency virus (Women living with HIV: WLWHIV) are at a six-fold increased risk of developing cervical cancer. This study assessed hrHPV types in cervical cancer by HIV status and histologic subtypes at Muhimbili National Hospital (MNH) in Tanzania.

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Migration policies have a significant impact on population health, particularly for individuals living with human immunodeficiency virus (HIV). These policies not only determine who is allowed to enter a country but also influence which immigrants can access services provided by the government. Some countries continue to impose restrictions on HIV-positive individuals, justifying these measures as necessary to protect public health and mitigate healthcare and economic concerns.

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Adaptive Gaussian Markov random fields for child mortality estimation.

Biostatistics

August 2024

Department of Biostatistics, University of Washington, Seattle, WA 98195, United States.

The under-5 mortality rate (U5MR), a critical health indicator, is typically estimated from household surveys in lower and middle income countries. Spatio-temporal disaggregation of household survey data can lead to highly variable estimates of U5MR, necessitating the usage of smoothing models which borrow information across space and time. The assumptions of common smoothing models may be unrealistic when certain time periods or regions are expected to have shocks in mortality relative to their neighbors, which can lead to oversmoothing of U5MR estimates.

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Background: Road traffic injuries (RTI) pose a global public health threat, especially in low- and middle-income nations. These injuries typically cause orthopaedic problems that may negatively impair a person's physical and mental health and quality of life. Our study examined the quality of life of road traffic orthopaedic injuries (RTOI) survivors.

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Article Synopsis
  • * A study in rural Rwanda explored the safety and effectiveness of the Warmer, revealing it was generally well-used, leading to improved temperatures in newborns without safety issues.
  • * Positive feedback from healthcare providers and parents highlighted the importance of ongoing education for proper use and engagement in thermoregulation to better support neonatal health.
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Identifying prey capture events of a free-ranging marine predator using bio-logger data and deep learning.

R Soc Open Sci

June 2024

Department of Statistical Sciences, Centre for Statistics in Ecology, Environment and Conservation (SEEC), University of Cape Town, Cape Town 7701, South Africa.

Marine predators are integral to the functioning of marine ecosystems, and their consumption requirements should be integrated into ecosystem-based management policies. However, estimating prey consumption in diving marine predators requires innovative methods as predator-prey interactions are rarely observable. We developed a novel method, validated by animal-borne video, that uses tri-axial acceleration and depth data to quantify prey capture rates in chinstrap penguins ().

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Introduction: Efforts toward reducing stroke burden have been an immense challenge. One important reasons could be the scope and quality of clinical practice guidelines (CPGs) developed for stroke rehabilitation in low- and middle-income countries (LMICs), restricting its translation to clinical practice. This systematic review aimed to assess the availability, scope and quality of CPGs for stroke rehabilitation in LMICs.

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Current status of the small molecule anti-HIV drugs in the pipeline or recently approved.

Bioorg Med Chem

September 2024

Faculty of Veterinary Science, University of Nyala, P.O. Box: 155, Nyala, Sudan; Nanotechnology in Veterinary Medicine (NanoVet) Research Group, Faculty of Veterinary Medicine, University Malaysia Kelantan, Kelantan 16100, Pengkalan Chepa, Malaysia.

Article Synopsis
  • Human Immunodeficiency Virus (HIV) causes Acquired Immunodeficiency Syndrome (AIDS) with significant health risks, especially in low- and middle-income countries due to increasing drug resistance and treatment challenges.
  • Progress is being made in developing new antiretroviral (ARV) drugs that target various HIV components and mechanisms, currently undergoing clinical trials, with specific compounds being discussed in terms of their efficacy and safety.
  • Continuous efforts are vital for advancing the discovery of innovative ARV treatments to mitigate drug resistance and improve patient outcomes, as there is currently no cure or vaccine for HIV.
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The 21st century presents significant global health challenges that necessitate an integrated health workforce capable of delivering person-centered and integrated healthcare services. Interprofessional collaboration (IPC) plays a vital role in achieving integration and training an IPC-capable workforce in sub-Saharan Africa (SSA) has become imperative. This study aims to assess changes in IPC confidence among learners participating in a team-based, case-based HIV training programme across diverse settings in SSA.

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This article draws upon 89 in-person surveys with Rwandan women (ages 26-75) whose partners were incarcerated for genocide and examines how these women explain participation in the violence. We first engage in exploratory factor analysis of reasons cited for perpetrating genocide, which reveals (1) a factor comprised of internal reasons for participation, including greed and hatred; (2) a factor of external reasons, such as peer pressure or coercion, and (3) a factor driven by alcohol use. Next, we analyze how these factors are associated with the women's psychosocial wellbeing as measured by the World Health Organization's Self-Reporting Questionnaire.

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Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries.

Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe.

Methods: From January 2019 to December 2022, we collected data from a cohort of children, adolescents, and young people receiving third-line ART from 9 sub-Saharan African countries.

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Introduction: In Rwanda, maternal community health workers play a critical role to improving maternal, newborn and child health, but little is known about their specific experiences with adolescent mothers, who face unique challenges, including trauma, ongoing violence, stigma, ostracism, mental health issues, barriers within the healthcare system, and lack of access to the social determinants of health. This study explored the experiences of maternal community health workers when caring for adolescent mothers in Rwanda to inform the delivery of trauma- and violence-informed care in community maternal services.

Methods: Interpretive Description methodology was used to understand the experiences of 12 community health workers purposively recruited for interviews due to their management roles.

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Background: The state of a child's nutrition is a critical indicator of their overall health and wellbeing. Public health still faces challenges from undernutrition, especially in developing nations across the globe. In Rwanda, around 33% of children aged under five years suffer from chronic undernutrition.

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Article Synopsis
  • The COVID-19 pandemic led to an increase in digital financial services, but its impact on maternal health services in low-resource settings is not well understood.
  • The study examined the effects of Madagascar's first COVID-19 lockdown on the usage of a mobile maternal health wallet among women, utilizing data from over 800,000 health wallet use instances.
  • Results showed significant declines in savings (58.5%), payments (45.8%), and voucher use (49.6%) during the lockdown, with recovery patterns varying by age, particularly indicating faster recovery for women over 30 years.
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The triple crises of the COVID-19 pandemic, conflict and climate change have severely impacted food systems, leading to socio-economic consequences and undermining food and nutrition security across Africa. To address the malnutrition and poverty affecting approximately 700 million people in Africa, there is potential for the One Health approach implementation and operationalization to bring together multidisciplinary solutions for tackling food insecurity and ensuring food safety net. However, there is limited documentation on the potential of the One Health approach system thinking implementation to guide responses to triple crises-induced food insecurity.

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Article Synopsis
  • Surface freshwater resources are declining globally due to climate change and land use alterations, with specific impacts in Cambodia affecting species like the critically endangered giant ibis.
  • A study from 2000-2020 revealed a 4.16% decrease in surface water, largely driven by economic land concessions and roads that increased extreme drying and flooding events, while protected areas offered some mitigation.
  • The giant ibis relies heavily on surface water for nesting, with 98% of nests located within 25m of water; the decline in surface water has led to a 25% reduction in suitable dry season habitat, threatening the species’ survival.
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Current estimates of temperature effects on plants mostly rely on air temperature, although it can significantly deviate from leaf temperature (T). To address this, some studies have used canopy temperature (T). However, T fails to capture the fine-scale variation in T among leaves and species in diverse canopies.

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Article Synopsis
  • The study investigates the link between post-traumatic stress disorder (PTSD) and differences in DNA methylation, a type of gene regulation, in blood samples from individuals diagnosed with PTSD compared to trauma-exposed controls.
  • Researchers conducted a large-scale analysis involving over 5,000 participants from various civilian and military studies, using standardized procedures for PTSD assessment and DNA methylation testing.
  • The results revealed 11 specific DNA methylation sites associated with PTSD, and found similarities in methylation patterns between blood and brain tissues, suggesting a biological basis for the condition.
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Functional neurological symptom disorder (FNSD) is a complex condition with multifactorial etiology in which psychological factors may play a significant role in some patients, and they are not universally present or necessary for the diagnosis. FNSD can occur in the absence of psychological distress and each patient's presentation should be evaluated individually, considering a wide range of potential contributing factors. This is the first report related to prevalence data from Rwanda.

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The COVID-19 pandemic resulted in drops in access to and availability of a number of evidence-based interventions (EBIs) known to reduce under-5 mortality (U5M) across a wide range of countries, including Rwanda. We aimed to understand the strategies and contextual factors associated with preventing or mitigating drops nationally and subnationally, and the extent to which previous efforts to reduce U5M supported the maintenance of healthcare delivery. We used a convergent mixed methods implementation science approach, guided by hybrid implementation research and resiliency frameworks.

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