Self-promotion as a risk factor for women: the costs and benefits of counterstereotypical impression management.

Three experiments tested and extended recent theory regarding motivational influences on impression formation (S. T. Fiske & S.

Trait hostility and ambulatory cardiovascular activity: responses to social interaction.

This study examined trait hostility and social interaction in relation to ambulatory cardiovascular activity in 40 male and 39 female undergraduates. Participants wore an ambulatory blood pressure monitor and completed diary entries while engaged in everyday activities. Diary reports indicating that participants had been talking were used to identify cardiovascular readings taken during social interaction.

The concentration of liquor outlets in an economically disadvantaged city in the northeastern United States.

This study reports data from a mapping analysis designed to assess the extent to which liquor outlets concentrate in certain neighborhoods within one economically disadvantaged midsized city in New Jersey. Four neighborhoods, which occupy one-quarter of the residential land mass of the city and which are home to one-quarter of its population, were found to contain over half of its retail liquor outlets. Three of these neighborhoods are very poor and have large minority populations.

The irrelevance of evidence in the development of school-based drug prevention policy, 1986-1996.

This article examines development in school-based drug prevention policy and programming since the Anti-Drug Abuse Act of 1986. Using data from national surveys and evaluations of school-based programs, it argues, first, that there was really no need for a massive infusion of money into school-based drug prevention in the late 1980s, and, second, that there was little or no evidence to indicate that a "new generation" of effective programs, based on the so-called social influence model, was emerging at this time. Despite the infusion of resources into school-based prevention efforts, adolescent drug use has risen in recent years.

The effects of dietary restriction on insulin-like growth factor (IGF)-I and II, and IGF-binding proteins in chickens.

The effect of feed (energy/protein) restriction on circulating concentrations of insulin-like growth factor (IGF)-I and II, and IGF-binding proteins (IGFBPs) was examined in young (4-week-old) chickens. Increasing levels of feed restriction caused progressive growth retardation, as evidenced by decreased body-weight gain and reduced bone growth. Plasma concentrations of both IGF-I and IGF-II were decreased, and the degree of reduction in the plasma concentrations of these growth factors appeared to be related to the magnitude of feed restriction.

Health-damaging personality traits and verbal-autonomic dissociation: the role of self-control and environmental control.

This study tested predictions derived from D.C. Glass's (1977) uncontrollability model regarding the link between control-related personality attributes and the dissociation of affective and autonomic responses to stress.

Offspring-induced nurturance: animal-human parallels.

Offspring provide mothers with stimuli that impel their own nurturance. In rats, distal sensory stimuli from pups--sight, sound, odor--contribute to contact-seeking, whereas tactile stimuli from pups to dam's snout and ventrum elicit essential maternal behavioral reflexes involved in retrieval, licking, and the quiescent, upright nursing posture (kyphosis). Brain sites involved with maternal behavior--assessed by lesions, immunocytochemical visualization of gene activity, and neurophysiological mapping--include the midbrain central gray, medial preoptic nucleus, limbic system, and somatosensory cortex; these may change with experience.

Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in the chicken following hatching.

The present study examined plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGF-binding proteins (IGFBPs) during posthatch growth and development in chickens. Three distinct proteins which bound 125I-IGF-I were observed irrespective of age or sex, these having apparent molecular weights of 22, 28, and 36 kDa. The major IGFBP present during much of the growth and development period was the 28-kDa form followed by the 36-kDa form.

Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.

Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor represents a unique posttranslational modification that is ubiquitously present in eukaryotic cells and archaebacteria. Specific inhibition of deoxyhypusine synthase leads to growth arrest and cell death. The precise cellular function of eIF-5A and the physiological significance of hypusine modification are not clear.

A thermal heat summation model to predict the duration of the gonotrophic cycle of Culiseta melanura in nature.

This study determined the effect of temperature on the gonotrophic cycle of Culiseta melanura and developed a thermal heat summation model to calculate its duration under field conditions. A colony of Cs. melanura was used from New Jersey (F13-F17 generation) and the length of the gonotrophic cycle was observed at 2, 10, 16, 22, 28, 32 and 34 degrees C.

Reciprocal talk between the auditory thalamus and the hypothalamus: an antidromic study.

In this study we sought to validate physiologically the hypothalamus afferent projections from the auditory thalamus previously identified with tract tracing techniques in the ring dove. In total, we recorded the responses of 628 units in the nucleus ovoidalis (Ov) and its shell region to electrical stimulation applied to anterior hypothalamus and ventromedial nucleus. Ninety-six acoustic units in the shell region displayed good antidromic responses, confirming this region's axonal projections into these nuclei of the hypothalamus.

Inhibitory effects of curcumin on tumorigenesis in mice.

Curcumin (diferuloylmethane), the naturally occurring yellow pigment in turmeric and curry, is isolated from the rhizomes of the plant Curcuma longa Linn. Curcumin inhibits tumorigenesis during both initiation and promotion (post-initiation) periods in several experimental animal models. Topical application of curcumin inhibits benzo[a]pyrene (B[a]P)-mediated formation of DNA-B[a]P adducts in the epidermis.

Ras oncogene-transformed and nontransformed cell populations are each heterogeneous but respond differently to the chemotherapeutic drug cytosine arabinoside (Ara-C).

In order to determine whether the growth of ras oncogene-transformed cells and nontransformed cells was inhibited differently by the chemotherapuetic drug cytosine arabinoside (Ara-C) their growth was analyzed by a novel colony-based assay that is sensitive and appropriate for heterogeneous cell populations. Colonies of nontransformed NIH3T3 cells, or ras oncogene-transformed NIH(ras) cells, were grown in the absence of drug and then divided into subclones. Subclones were allowed to continue to grow in the absence or presence of drug.

Measuring diagnostic agreement.

Diagnostic agreement tests the reliability and concordance of diagnostic systems. The introduction of measures of agreement with reputations for baserate independence (e.g.

Mutual hairless rat skin permeation-enhancing effect of ethanol/water system and oleic acid.

The mutual hairless rat skin permeation-enhancing effect of ethanol (EtOH)/water systems and oleic acid (OA) was investigated with model lipophilic (estradiol, progesterone, levonorgestrel) and hydrophilic drugs (zalcitabine, didanosine, zidovudine). The aqueous solubility and hairless rat skin permeation rate of each drug, saturated in various compositions of EtOH/water system (with and without OA), was determined at 37 degrees C. The hairless rat skin permeation rates of ethanol from EtOH/water systems (with and without OA) were also measured to investigate the skin permeation-enhancing mechanism of EtOH/water systems and OA.

A measure of self-care self-efficacy.

Strategies Used by People to Promote Health (SUPPH), a 29-item self-report, is a measure of self-care self-efficacy. Items for the SUPPH were empirically generated, validated by an expert panel, and tested (N = 275) for psychometric properties, factor composition, and convergent and discriminant evidence with existing scales. Good initial psychometric properties were found for the SUPPH and four factors emerged: coping, stress reduction, making decisions, and enjoying life.

Rational design of receptor partial agonists and possible mechanisms of receptor partial activation: a theory.

Partial activation of membrane receptors using specific partial agonists may be particularly beneficial to the treatment of some chronic diseases like congestive heart failure, because receptor partial activation usually avoids overstimulation and also minimizes desensitization. At present, partial agonists are obtained almost exclusively by screening numerous newly-synthesized compounds, and little is known about the rational design of partial agonists with desired potencies and maximum activities. It is proposed in this study that a proper covalent attachment of a receptor full agonist to an antagonist (competitive or non-competitive) of the same receptor type may form a hybrid compound with a reduced maximum activity.

Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination.

Hairpin polyamides are synthetic ligands for sequence-specific recognition in the minor groove of double-helical DNA. A thermodynamic characterization of the DNA-binding properties exhibited by a six-ring hairpin polyamide, ImPyPy-gamma-PyPyPy-beta-Dp (where Im = imidazole, Py = pyrrole, gamma = gamma-aminobutyric acid, beta = beta-alanine, and Dp = dimethylaminopropylamide), reveals an approximately 1-2 kcal/mol greater affinity for the designated match site, 5'-TGTTA-3', relative to the single base pair mismatch sites, 5'-TGGTA-3' and 5'-TATTA-3'. The enthalpy and entropy data at 20 degrees C reveal this sequence specificity to be entirely enthalpic in origin.

Configural processing in the perception of apparent biological motion.

In classic demonstrations of apparent motion, observers typically report seeing motion along the shortest possible path between 2 sequentially presented objects. However, when realistic photographs of a human body are sequentially presented at slow temporal rates, observers report paths of apparent motion that are consistent with the movement limitations of the human body even when those paths are not the shortest possible. The current set of experiments examined those aspects of the human form that lead to the perception of biomechanically consistent paths of motion.

Characterization of in-vitro spermicidal activity of chelating agent against human sperm.

The effect of ethylenediaminetetraacetic acid (EDTA), a cationic chelating agent, on sperm motility and sperm penetration through cervical mucus was evaluated. EDTA exerted a relatively mild dose-dependent effect on sperm motility. Total loss of sperm motility (EC100) was achieved at a concentration of about 5.

Similarities and differences in the glucuronidation of estradiol and estrone by UDP-glucuronosyltransferase in liver microsomes from male and female rats.

In this study, we evaluated the effects of pH, in vitro inhibitors, in vivo enzyme inducers, age, and sex on the glucuronidation of estradiol and estrone by rat liver microsomes. Although the pH dependence curves for the glucuronidation of estradiol and estrone were similar, the pH dependence curves for these estrogens by liver microsomes from adult male rats were very different from those by liver microsomes from adult female rats. These results suggest that liver microsomes from adult male and have different estrogen glucuronosyltransferases.

Characterizing the DNA binding modes of a topoisomerase I-poisoning terbenzimidazole: evidence for both intercalative and minor groove binding properties.

We have used a broad range of spectroscopic and viscometric techniques to demonstrate that the complexation of a cytotoxic, topoisomerase I-poisoning terbenzimidazole (5PTB) with the poly(dA).poly(dT) duplex exhibits properties characteristic of both intercalation and minor groove binding. Our results reveal the following features: (i) Optical melting profiles reveal that 5PTB binding enhances the thermal stability of the poly(dA).