miR-708 Negatively Regulates TNF/IL-1 Signaling by Suppressing NF-B and Arachidonic Acid Pathways.

Two pathways commonly dysregulated in autoimmune diseases and cancer are tumor necrosis factor alpha (TNF) and interleukin 1 beta (IL-1) signaling. Researchers have also shown that both signaling cascades positively regulate arachidonic acid (AA) signaling. More specifically, TNF/IL-1 promotes expression of the prostaglandin E2- (PGE-) producing enzymes, cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1).