[Features of lung damage in baclofen poisoning].

Objective: To reveal pathological lung changes in baclofen poisoning and to assess their dynamics.

Material And Methods: The experiment included 20 mature (at age 20 weeks) male rats of Wistar line weighing 290-350 gr. The animals were divided into 3 study groups (5 rats in each) depending on experiment's duration after 85 mg/kg baclofen administration: 3, 4.

Baclofen (fun drug) and ethanol combined poisoning in humans: A histopathology and morphometry model.

Background: - This study intends to address the scarcity of data regarding the pathogenesis of Baclofen poisoning in humans, which has seen a recent increase, worldwide, especially amongst the young people. Another reason for the conduction of this study was lack of the substantial data about the histo-pathological findings of lungs, in synergistic toxicity of Baclofen with Ethanol, in-spite of it being very common in humans, and both being respiratory depressant with similar mechanism of action.

Purpose: - The authors aimed to understand the pathogenesis of fatal poisonings in humans due to Baclofen in combination with Ethanol via an animal research model.

Sudden death due to rupture of an aortic syphilitic aneurysm.

A 26-year-old man who suddenly collapsed and died was found at autopsy to have a ruptured aortic aneurysm which had the classic "tree bark" appearance of tertiary syphilis. Tracking of blood into the pericardial sac had resulted in sudden death from cardiac tamponade. Serological results were consistent with syphilis and HIV was excluded.

[Medical rehabilitation of patients with alcohol dependency at risk of parental rights deprivation].

Aim: To study the efficacy of medical rehabilitation outpatient program 'Point of Soberness' with the use of prolonged injectable naltrexone for alcohol dependent parents of minor children.

Material And Methods: One hundred and seventeen patients with severe disease form without remissions were enrolled in the study. All patients were parents at risk of deprivation of parental rights.

Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia.

In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.

Characteristics of circadian rhythm of blood pressure during long-term hypertension development in SHR rats.

The specific features of circadian rhythm of BP were investigated in freely moving male SHR rats using telemetry monitoring technique. BP was recorded in the abdominal aorta according to 24-h/4-month schedule. The data were obtained from 22, 26, 30, 34, and 38-week-old animals.

The study of immunological component in antitumor effect of Trypanosoma cruzi.

The experiments with passive transfer of splenocytes obtained from animals immunized with Trypanosoma cruzi lysate revealed the role of cell-mediated component of the immunity in the antitumor effect of T. cruzi. The common features of T.

Blood pressure and contractile function of heart ventricles at the early stages of hypertonic process.

In rabbits, arterial hypertension was characterized by progressive elevation of systolic and diastolic blood pressure. The contractile function of the left ventricle augmented, but its potential working capacity decreased. Opposite changes were observed in the right ventricle.

Changes in myocardial blood supply during experimental hypertension treated with verapamil in rabbits.

Rabbit hearts were studied at different periods of experimental arterial hypertension and its treatment with verapamil. Morphological study revealed a progressive decrease in the number of capillaries per unit mass during the development of myocardial hypertrophy in hypertensive hearts. In hypertensive animals treated with verapamil the density of capillaries in both ventricles did not decrease, but verapamil injected to intact animals sharply decreased this parameter.

Initial mechanisms of the development of hypertonic heart.

In rabbits, arterial hypertension was simulated according to Goldblatt. One, 2, 4, and 6 weeks after surgery, the hearts of control and experimental animals were extirpated for morphological examination. In semithin sections of the left and right ventricles, morphometry was performed using an Avtandilov grid.

Ultrastructural changes in myocardium of hypertensive rats treated with nifedipine.

Spontaneously hypertensive rats (SHR) with high systolic pressure received calcium antagonist nifedipine in medium therapeutic doses for 2 weeks. Electron microscopy of the myocardium revealed considerable changes in the sarcoplasmic reticulum manifested in dramatic dilation of tubules, destruction of membranes, and appearance of amorphous matter of medium electron density in tubules in animals treated with nifedipine. Since sarcoplasmic reticulum plays an important role in calcium-dependent excitation-contraction coupling, the observed structural changes can underlie the negative inotropic effect of long-term nifedipine therapy.

Osteovisceral afferent interrelations.

The effects of stimulation of intraosseus receptors on visceral afferent reactions were studied in experiments on anesthetized cats. Stimulation of intraosseus receptors decreased the thresholds of evoked potentials recorded in the cerebral cortex in response to stimulation of the heart, stomach, and duodenum. It was concluded that stimulation of intraosseus receptors during osteopathy (e.

Morphological and functional state of the heart during magnetic storm.

Magnetic storm modulates morphological and functional state of the heart and the related systems. Changes in cardiomyocyte ultrastructure induced by changes in geomagnetic activity were studied in experiments on rabbits. We describe a possible mechanism underlying changes in cardiac activity in intact animals induced by geomagnetic perturbations.

Biorhythmologic aspects of seizure activity.

Seasonal and circadian rhythms of neuronal and organism resistance to convulsive effect of strychnine and penicillin were studied in vivo on mice and rats and in vitro on cultured mouse cerebellar sections. Resistance was assessed by the latency of seizures in mice and neuronal response to convulsants in sections. In the night and morning time (0:00-9:00) seizure resistance in mice increased: it manifested in longer latency and lower mortality compared to those in the day and evening time (12:00-21:00).

Possible mechanism of regression of myocardial hypertrophy.

Structure of the myocardium was studied in rabbits with renovascular hypertension during the development of myocardial hypertrophy and its regression under the effect of beta-adrenoceptor antagonist lopressor. Myocardial hypertrophy was associated with ultrastructural changes in cardiomyocytes, while lopressor therapy led to their regression and normalization of cardiomyocyte ultrastructure. Regression of hypertrophic changes was accompanied by a marked increase in the number of extracellular nuclei, which indicated enhanced apoptosis of cardiomyocytes.

Clinical symptoms of acute coronary insufficiency correlate with GP-IIIa genotype of integrin beta-subunit.

Studies of the clinical course of acute coronary insufficiency (progressive angina and myocardial infarction) in patients carrying a mutant allele of the Pl-A(II) gene encoding integrin GPIIIa beta-subunit revealed significant differences in the incidence of some clinical signs in comparison with patients homozygous for the normal Pl-A(I) allele.

[Cosmetic interlamellar keratoplasty].

Interlamellar transplantation of the cornea was performed with cosmetic purpose in 9 patients with blind eyes (coarse vascularized leukoma in 5 and cataracts with newly formed iridal and anterior chamber vessels in 4) and in 2 with peripheral leukomas. The technique of interlamellar keratoplasty consisted in transplantation of a stained disk of donor cornea in the recipient's corneal membrane layers or stratification of the peripheral leukoma followed by carbon black staining. The operation is simple, little traumatic, and brings about a good cosmetic effect in the cases when other methods are impossible to use; the risk of intra- and postoperative complications is minimal.