[Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure].

Chronic heart failure (CHF) is a common complication of patients with heart dysfunction and of those suffering from various chronic illnesses. Although recently developed therapies revolutionized treatment of CHF, life expectancy of the survivors is still significantly reduced. Proposed neurohoromonal approach in CHF treatment is on the whole rather unsatisfactory.

[Differential gene expression analysis by DNA microarrays technology and its application in molecular oncology].

Accumulation of genetic and epigenetic aberrations leads to malignant transformation of normal cells. Functional studies of cancer using genomic and proteomic tools will help to reveal the true complexity of the processes leading to cancer development in humans. Until recently, diagnosis and prognosis of cancer was based on conventional pathologic criteria and epidemiological evidence.

Role of the autonomic nervous system in the development of cardiac arrhythmias in cats with acute myocardial ischemia receiving thyroliberin.

The role of the autonomic nervous system in the development of ischemic cardiac arrhythmias was studied in acute experiments on cats receiving thyrotropin-releasing hormone. Bilateral vagotomy attenuated, while bilateral transection of cardiac branches of the stellate ganglia completely abolished the antiarrhythmic effect of thyrotropin-releasing hormone.

Whether independent regulation of myocardial contractility and diastolic relaxation rate is possible?

In acute experiments on cats neural inotropic and lusitropic reactions of the heart to enhancement of pre- and afterload were assessed by changes in contractility and relaxation indices, which were preliminary chosen for their maximum specificity and sensitivity. The control cardiac responses to increased pre- and afterload were measured after treatment with ganglionic blocker arfonad. The myogenic component of these responses assessed under the action of arfonad was highly pronounced, therefore the neural inotropic and lusitropic reactions were measured as the difference between load-induced changes of indices in experiments with and without arfonad.

Mechanism of synergism between sympathetic and parasympathetic autonomic nervous systems in the regulation of motility of the stomach and sphincter of Oddi.

The mechanisms of stimulatory effect of the sympathetic trunk on gastric motor activity and vagal inhibitory effect on electromotor activity of the sphincter of Oddi were studied. Gastric contractions were augmented by preganglionic serotoninergic fibers related synaptically to serotoninergic neurons, while inhibition of electromotor activity of the sphincter of Oddi was elicited by activation of alpha- and beta-adrenoceptors.

Chronotropic and dromotropic components of cardiac reflexes in rabbits.

The relationships between dromotropic and chronotropic components of five reflexes were studied in rabbits: intravenous and intraarterial blood injections, occlusion of the carotid arteries, Aschner maneuver, and stimulation of depressors. All these stimuli reduced heart rate (except carotid artery occlusion, which induced approximately equal number of tachi- and bradycardic responses). The former three stimuli also reduced atrioventricular (AV) conduction velocity, the changes in these two parameters were proportional.

[Status of the upper parts of the digestive tract and Helicobacter pylori infections in patients with chronic kidney failure after kidney transplantation].

The purpose of the study was to examine the state of upper parts of the digestive tract, prevalence of Helicobacter pylori infection and its relation to the pathology revealed in patients with chronic renal insufficiency after kidney transplantation.

[Effect of geomagnetic activity on the rhythm of resistance of rats to hypoxia].

The resistance of male Wistar rats to acute hypoxia was estimated from the lifetime at an "altitude" of 11.5 km above sea level from 13 to 21 p.m.

[Effect of low intensity laser light in the red range on macrophage superoxide dismutase activity].

The effect of lipopolysaccharides (LPS) and low-power laser radiation on nitric oxide (NO) production and the activity of superoxide dismutase (SOD) in rat peritoneal exudate macrophages was investigated. It was found that LPS increased NO production and SOD activity in macrophages in a concentration-dependent manner. The maximal activity of SOD was more than 100 times greater than in the control and was achieved at an LPS concentration of less than 10 ng/ml.

Peripheral macrohemodynamics in patients with lower limb arteriosclerosis obliterans and type II diabetes mellitus.

The paper presents characteristic features of lower limb atherosclerotic lesions in patients with diabetes mellitus: more prominent calcification of vascular wall (involving media), frequent involvement of distal vascular segments and a symmetry of lesions. Typical variants are shown in images obtained with duplex angioscanning. The authors conclude that there are no principal differences in the course of lower limb arteriosclerosis obliterans between diabetics and non-diabetics.

[Phlebosclerosing treatment of lower extremity varicosity using the 'foam-form' technique].

This paper presents an experience gained with the treatment of 39 patients with lower extremity varicosity using a novel method of phlebosclerosing treatment, named the foam-form technique. The authors give a detailed description of the treatment modality, analyze the short- and long-term results. The conclusion is drawn that the given method is safe and effective.

Anatomic and hemodynamic changes in the inferior vena cava associated with prevention of pulmonary thromboembolism.

This paper analyzes the results of a multimodality instrumental study of the structural and functional properties of the inferior vena cava (IVC) in 173 patients with acute venous thrombosis, who underwent different interventions aimed at pulmonary thromboembolism (PTE) prevention. Of these, 63% of patients were examined in the long-term period, within the time 2 to 36 months. 26% of patients were found to have variants of the anatomic structure of the IVC system, such as the doubling of the renal veins, ring-shaped structure or entry to the IVC at a distance exceeding 5 cm from each other.

Extravasal occlusion of large vessels with titanic clips: efficiency, indications, and contraindications.

The mechanism of extravasal occlusion of blood vessels with titanic clips "Atrauclip" and "Ligaclip extra" was studied in order to reveal indications and contraindications to their use. Occlusion with the clips of both types was ineffective in vessels with a diameter of >7.0 mm.

Effect of thyrotropin-releasing hormone on the development of cardiac arrhythmias during stimulation of sensorimotor cortex in cats.

Preliminary intravenous injection of thyrotropin-releasing hormone in a dose of 20 g/kg to cats with developing myocardial ischemia during stimulation of the cerebrocortical sensorimotor zone had a pronounced antiarrhythmic effect.

Structural and metabolic characteristics of liver acini in dogs with acute cholecystitis.

Structural and metabolic changes in liver tissue in dogs with acute cholecystitis were studied by histological, histoenzymatic, and biochemical methods. It was found that the development of destructive inflammatory processes in the gallbladder wall induces morphological damage to the liver tissue, which correlates with metabolic disorders in this organ and leads to liver dysfunction.

Tissue hypoxia and intestinal dysbiosis in children with tuberculosis.

We studied the role of autochthonous microflora from body cavities in the development of tissue hypoxia and instability of cell membranes. In children with tuberculosis dysbiosis manifested in nonspecific quantitative changes in the intestinal microflora and the presence of coxsackievirus antigens in the urine. DNA-containing viruses with pronounced immunosuppressive activity (e.

Experimental validation of videoendoscopic isolation and occlusion of the bloodflow in open ductus arteriosus.

The potentialities of videoendoscopic isolation and extravasal occlusion of large vessels with titanium clips were studied in acute and chronic experiments on 36 animals and anatomic studies on 5 human cadavers. The number and optimal sites for insertion of trocars and disposition of instruments and thoracoscope for isolation of open ductus arteriosus were determined. A method for videoendoscopic isolation of vessels is developed and possible complications and measures for their liquidation evaluated.

Morphometric characteristics of liver acini in dogs with acute cholecystitis.

Morphometric analysis of the liver in dogs with acute cholecystitis revealed specific alterations in liver acini in various forms of acute cholecystitis.

[Photohemolysis sensitized by deuteroporphyrin-IX derivatives: determination of binding strength of dyes to erythrocytes].

A comparative analysis of the ability of 4-(1-methyl-3-hydroxybutyl)-deuteroporphyrin-IX (I) and 2,4-di-(1-methyl-3-hydroxybutyl)-deuteroporphyrin-IX (II) to photosensitize hemolysis of human erythrocytes was performed. The photohemolytic efficiency of dye I was shown to be about 60 times higher than that of dye II. It was found that a part of each dye tightly binds to erythrocyte membranes and is not removed by washing.

[Comparative estimation of results of remote and combined radiotherapy in patients with cancer of the cervix uteri of the III-IV stages of disease].

The paper presents a procedure of teleradiotherapy in patients with stages III-IV cancer of the cervix uteri with significant concurrent pathology. Control patients with the similar disease stages underwent combined radiation therapy. If there are contraindications to combined radiation therapy, teleradiotherapy is possible and required as an independent treatment that prolongs and improves the patients' like quality irrespective of the extent of a tumorous process.