Taban-Arshan: immunocorrector in atopic bronchial asthma.

Taban-Arshan extract decreased expression of T-lymphocyte activation markers, normalized T-cell-mediated immunity, and suppressed increased activity of natural killer receptors during culturing with lymphocytes of patients with atopic bronchial asthma. Taban-Arshan extract normalized activation processes in the B-cell immunity and stimulated expression of receptors of activation-induced apoptosis.

Spatiotemporal organization of the proliferative system in small intestinal crypt epithelium of intact mice.

We studied spatiotemporal organization of the proliferative system in small intestinal crypt epithelium of normal mice. Close relationships were found between circadian rhythms of cell proliferation and their position in the crypt. These peculiarities reflected spatiotemporal organization of the crypt epithelium.

[Effect of moxonidine on parameters of lipid metabolism in patients with metabolic syndrome.].

Aim: To compare effects of moxonidine and lisinopril on parameters of lipid metabolism in patients with metabolic syndrome.

Methods: Moxonidine (0.2-04 mg/day) and lisinopril (10-20 mg/day) were given to 25 and 24 patients, respectively.

Wound-healing effect of papaya-based preparation in experimental thermal trauma.

Treatment with the phytopreparation from papaya accelerated wound healing and reduced the severity of local inflammation in rats with burn wounds. The effect of this phytopreparation can be related to an increase in the effectiveness of intracellular bacterial killing by tissue phagocytes due to the inhibition of bacterial catalase. Antioxidant activity of the preparation decreases the risk of oxidative damage to tissues.

Effect of low-energy laser irradiation on the area of experimental myocardial infarction, lipid peroxidation, and hemoglobin affinity for oxygen.

The mechanism of antiischemic effect of low-energy laser radiation was studied in rats with experimental myocardial infarction taking into consideration the effect of laser on hemoglobin affinity for oxygen and intensity of lipid peroxidation. Low-energy laser irradiation for 15 min in vitro decreased the area of myocardial infarction, slightly reduced hemoglobin affinity for oxygen, and inhibited lipid peroxidation. Short-term low-energy laser irradiation did not reduce the area of necrosis, initiated lipid peroxidation, and increased superoxide dismutase activity.

Connection between p53 gene Bam HI RFLP polymorphism with the volume of brain infarction in patients with carotid atherothrombotic ischemic stroke.

Purpose: The aim of our investigation was to study the connection between p53 gene Bam HI RFLP polymorphism and the brain infarction volume in patients with atherothrombotic ischemic stroke that could highlight certain genetic aspects of the individual sensibility of brain tissue to acute ischemia.

Materials And Methods: Diallelic Bam HI RFLP polymorphism in 5' flanking region p53 gene was studied in 96 patients with carotid atherothrombotic stroke from Moscow population. Magnetic resonance imaging was conducted on day 7 after the stroke onset.

[Fetal arrhythmias: pathogenetic mechanisms and clinical aspects].

The paper contains analysis of literature data on pathogenesis, clinical aspects and treatment of various kinds of fetal arrhythmia as well as data of authors own studies in the field.

Endovasal laser obliteration of the greater saphenous vein in patients with varicosis.

This paper describes the first results of endovasal laser obliteration of the greater sephenous vein in two patient groups (n=40) math varicosis. In 15 cases (control group), laser obliteration was employed during routine operation as an alternative to phlebectomy according to Babcock following crossectomy. In 25 patients (the main group), operation was performed without ligation of the saphenofemoral anastomosis.

Chronic diseases of lower extremity veins in industrial workers of Moscow (results of the epidemiological survey).

This paper describes the results of the study into the prevalence of chronic venous diseases among industrial workers of Moscow. It has been established that chronic venous diseases are fairly prevalent among industrial workers. They affect the people of both sexes (67.

Evaluation of the efficacy of heparins of varying molecular mass and duration of their use in the treatment of patients with acute venous thrombosis.

This paper analyses the results of examination and treatment of 90 patients with acute thrombosis in the inferior vena cava system. To verify the diagnosis, use was made of contrast phlebography (retrograde iliocavography), ultrasound angioscanning, and perfusion scanning of the lungs, The treatment was carried out using heparins of varying molecular mass given for a short and longer time together with indirect anticoagulants. It has been demonstrated that the use of low-molecular heparin does not produce any noticeable changes in the hemostatic system, which can be revealed by standard coagulation tests.

[Critical ischemia resulted from inadequate outpatient management of lower limb chronic arterial obliterations].

Management of critical and subcritical lower limb ischemia poses a challenge due to poor effectiveness and high costs of therapy. Problem solving supposes not only the development of effective surgical and medical management of severe arterial insufficiency, but also preventive efforts on early outpatient stage. The paper reviews 611 patients with lower limb arterial obliterative lesions and correlates age, sex, concomitant diseases, stage of arterial insufficiency and risk factors.

[Molecular and cellular mechanisms of the low intensity laser radiation effect].

The main aspects of the free radical conception of the molecular and cellular mechanisms of the stimulating action of low-intensity radiation in the red region of the spectrum were considered. These are: (1) Primary acceptors of incident radiation are endogenous porphyrins, which may act as photosensitizers giving initiator-radicals for secondary free radical reactions. (2) Target cells for light irradiation during quantum therapy may be blood leukocytes, fibroblasts, keratinocytes, endotheliocytes, etc.

[Photobiophysics of furanocoumarins].

Furocoumarins (psoralens) are photosensitizers of plant origin, which increase the sensitivity of biological objects to near ultraviolet (UV-A, 320-400 nm). In combination with UV-A, they are successfully used for treating many dermal and autoimmune diseases (PUVA therapy and photophoresis). Along with therapeutic effects, the furocoumarin photochemotherapy induces a number of side-effects (erythema, edema, hyperpigmentation, and premature aging of skin).

A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system.

Background: Whether for cell culture studies of protein function, construction of mouse models to enable in vivo analysis of disease epidemiology, or ultimately gene therapy of human diseases, a critical enabling step is the ability to achieve finely controlled regulation of gene expression. Previous efforts to achieve this goal have explored inducible drug regulation of gene expression, and construction of synthetic promoters based on two-hybrid paradigms, among others.

Results: In this report, we describe the combination of dimerizer-regulated two-hybrid and tetracycline regulatory elements in an ordered cascade, placing expression of endpoint reporters under the control of two distinct drugs.

Oxygen-dependent mechanisms underlying the antiischemic effect of verapamil and amlodipine.

Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxygen.

Experimental gastric ulcer: gastro- and duodenoprotective effects of sibusol.

We studied the influence of pretreatment with chemical mildronate analogue sibusol on the course of experimental gastric ulcer in rats. Sibusol produced a protective effects on the stomach and duodenum.

On the problem of innervation of the biliary tracts.

We studied the possibility of co-directed stimulatory effects of the sympathetic and parasympathetic systems on the motility of gallbladder, Oddi sphincter, and adjacent ascending portion of the duodenum. It is established that serotoninergic intramural neurons transmitting excitatory influences to(5)HT(1,2)-serotonin receptors of the effector tissues participate in this stimulatory effect.

[Role of pericytes in mechanism of vessel neovascularisation in the regenerating connective tissue].

This work presents the data of electron microscopic study of cellular interrelations in the process of capillary growth in the regenerating connective tissue. The study was performed in 28 albino rats which have been implanted with different polymer nets in the muscle defects of anterior abdominal wall. A combined activation of both endothelial cells (EC) and pericytes was demonstrated during the earliest stages of angiogenesis.

[Probable mechanisms of the regulation in the jejunum motility].

It is a well-known fact that serotonin has a stimulative action on the motor-secretory activity of the gastrointestinal tract. Activation of 5HT3,4-receptors regulates neuronal responses of this action; it is possible to regulate efferent reactions by activating 5HT1,2-receptors (1, 2, 3). Carcinoid cells containing 5HT have 5HT3 and 5HT4 receptors on their superficial membranes.

[Morphological features of juvenile colon polyps in children].

Histological, histochemical and immunohistochemical studies of 50 solitary juvenile polyps (JP) and 50 JP from children with juvenile polyposis syndrome (JPS) were performed. Observations of the focal complex glandular structures with high mitotic rate were more frequent in JP from patients with JPS (n = 29, 58%) than in solitary JP (n = 17, 34%) (p < 0.03).

[Antistaphylococcal activity of the complex of natural cytokines].

The in vitro study of the action of the complex of natural cytokines (CNC), or preparation Superlymph, on different microbial test strains (Staphylococcus aureus, Escherichia coli, yeast-like fungi of the genus Candida) was carried out. CNC suppressed the growth of S. aureus test culture, depending on the concentration of the preparation.

Photobiological principles of therapeutic applications of laser radiation.

Laser therapy based on the stimulating and healing action of light of low-intensity lasers (LIL), along with laser surgery and photodynamic therapy, has been lately widely applied in the irradiation of human tissues in the absence of exogenous photosensitizers. Besides LIL, light-emitting diodes are used in phototherapy (photobiostimulation) whose action, like that of LIL, depends on the radiation wavelength, dose, and distribution of light intensity in time but, according to all available data, does not depend on the coherence of radiation.