[The analysis of the association of the polymorphic variants of the TPMT, COMT, and ABCC3 genes with the development of hearing disorders induced by the cisplatin treatment].

Cisplatin and its derivatives are widely used chemotherapeutic agents for the treatment of many cancers, including hepatoblastoma, brain tumors, and germ-cell tumors. This therapy contributed to the dramatic increase in the survival rate. However, its use is restricted by the high incidence of irreversible ototoxicity associated with cisplatin application (in more than 60% of the children receiving it).

[Changes of the auditory function in he children with chronic kidney failure].

Unlabelled: The risk factors that contribute to the development of hearing loss in the children with chronic kidney failure (CRF) are complications and/or manifestations of the disease itself as well as the side effects of its treatment. There are many similarities between the anatomical, physiological, and pharmacological features of the nephron and the striavascularis of the cochlea. The objective of the present study was the evaluation of the status of the auditory function in the children presenting with CRF.

[The management of patients with congenital malformations of the external and middle ear].

Rehabilitation of the patients suffering from with congenital malformations of external and middle ear is a specific area of medicine requiring special knowledge and skills of the audiologists and ear surgeons. This article highlights the issues of epidemiology, classification and methods for the rehabilitation of patients presenting with this pathology that reflect our own experience and the methodology based on it for all phases of both functional and aesthetic surgical inerventions. Special attention is given to the assessment of the effectiveness of the treatment, as part of the evaluation of the quality of medical services.

[The application of the screening questionnaires for the diagnostics of the central auditory processing disorders in the pediatric practice].

Identification and diagnostics of auditory processing disorders (APD) in the children continues to be a challenge. Screening tools help to decide the need for evaluation. However, none of them are used routinely in Russia, nor are there thus far auditory checklist questionnaires in the Russian language.

[Epidemiology of hearing loss in children of the first year of life].

The aim of this study was the investigation of the epidemiology of permanent hearing impairment in the children of first year of life in the Russian Federation after the implementation of the newborn universal hearing screening program. The prevalence of hearing loss in children in the first year of life was estimated at 2.5 per 1,000 based on the official statistical data and reports of hearing rehabilitation centres in 2016.

[Twenty years of clinical studies of GJB2-linked hearing loss in Russia].

The most common cause of congenital hereditary hearing loss was discovered 20 years ago in 1997 when GJB2 gene was revealed in the first locus of recessive hearing loss DFNB1. It encodes protein connexin 26, a structural component of the intercellular channels. Recessive mutations in this gene cause the congenital bilateral sensorineural hearing loss.

[The method for the simultaneous registration of several frequency-specific short latency auditory brain-stem responses].

The present article was designed to describe the newly proposed method for the simultaneous registration of several frequency-specific short latency auditory evoked potentials based on the use of the sequences of the maximum length. The mutual masking between he sequences of different frequency bands was investigated. The possibility for the simultaneous registration of five responses to the stimuli with the central frequency of 0.

[Evoked potentials in the rehabilitation of the patients after cochlear implantation].

The objective methods for the hearing examination of the patients after cochlear implantation provide an important tool for the speech processor fitting. The aim of the present study was to evaluate the possibilities and the informative value of the electrically evoked compound action potential (ECAP) and electrically evoked auditory brainstem response (EABR) combined recording technique. For this reason, the comparison of the ECAP and EABR thresholds with comfortable levels of stimulation, obtained on the basis of subjective response and psychophysical testing of the patients with good results after cochlear implantation was performed.

[Auditory evoked potentials in children with auditory neuropathy spectrum disorder].

The objective of the present study was to estimate peculiarities of the auditory brainstem evoked potentials (ABR), auditory steady-state responses (ASSR) and cortical auditory evoked potentials (CAEP) in the children presenting with bilateral auditory neuropathy spectrum disorder (ANSD). The study included 100 patients with bilateral ANSD diagnosed based on the positive response of otoacoustic emissions (OAEs) and/or cochlear microphonic (CM) detection, while no synchronous neural activity was detected in the ABR test. Cochlear microphonic was the main clue for the ANSD diagnosing, because OAE was absent in both ears of 49 children.

[The electrically evoked potentials of the auditory cortex].

The problems concerning the registration of late latency auditory responses to electric stimulation in the patients wearing cochlear implants are considered. The renewed interest to this class of evoked potentials is due to unexplained differences in the results of cochlear implantation in the patients with the similar audiological data, etiology, age and the history of deafness as well as cochlear implant surgery in children of first years of life and the extended possibilities for speech processor programming. It is maintained that the advantages of this method include the possibility to objectively evaluate the ability of brain to detect and discriminate between different stimulus characteristics, such as loudness differences, temporal changes or speech tokens.