A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms.

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription factors.

Emerging roles of long noncoding RNA H19 in human lung cancer.

Lung cancer holds the position of being the primary cause of cancer-related fatalities on a global scale. Furthermore, it exhibits the highest mortality rate among all types of cancer. The survival rate within a span of 5 years is less than 20%, primarily due to the fact that the disease is often diagnosed at an advanced stage, resulting in less effective treatment options compared to earlier stages.

[The Russian priority in development of general intravenous anesthesia (Report II)].

The article considers evaluation of works of colleagues and contemporaries of N. P. Kravkov, the creator of "Russian narcosis" with hedonal.

[The Russian priority of development of intravenous anesthesia (Report I).].

The article analyses research activities of the discoverers of "Russian narcosis" from the Military Medical Academy of St. Petersburg: the head of the Department of Pharmacology N. P.

Reduction of cost and emissions by using recycling and waste management system.

In order to evaluate the level of sustainability of an integrated waste management system (IWMS), it is necessary to analyze the impact criteria. Therefore, the purpose of this study is to provide a model for IWMS optimization with the two goals of minimizing the cost and the emission of greenhouse gases of the entire system. Environmental and health problems caused by the lack of proper waste management include the increase in disease, increase in stray animals, pollution of air, water, land, etc.

Identifying the Risk Factors of Allergic Rhinitis Based on Zhihu Comment Data Using a Topic-Enhanced Word-Embedding Model: Mixed Method Study and Cluster Analysis.

Background: Allergic rhinitis (AR) is a chronic disease, and several risk factors predispose individuals to the condition in their daily lives, including exposure to allergens and inhalation irritants. Analyzing the potential risk factors that can trigger AR can provide reference material for individuals to use to reduce its occurrence in their daily lives. Nowadays, social media is a part of daily life, with an increasing number of people using at least 1 platform regularly.

[Modern strategies for the management of patients who have suffered ischemic stroke or transient ischemic attack].

Modern strategies for secondary prevention of ischemic stroke (IS) are based on long-term use of drugs from three main pharmaceutical groups (antihypertensive, lipid-lowering and antithrombotic drugs). In practical terms, the most difficult thing for a practitioner is the choice of antithrombotic therapy with anticoagulants or antiplatelet agents. Antithrombotic therapy for patients with acute cerebrovascular accidents has changed significantly in recent years.

The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review.

Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron ( L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize.

Scientometric analysis of trends in global research on acne treatment.

Unlabelled: Acne or acne vulgaris is the most common chronic inflammatory disease of the sebaceous follicles.

Objectives: The present study aims to identify the main lines of research in the field of acne treatment using reproducible scientometric methods. In this article, we reviewed the following research trends: facial acne, different antibiotics, retinoids, anti-inflammatory drugs, epidermal growth factor receptor inhibitors therapy, and associated diseases.

How Do COVID-19 Risk, Life-Safety Risk, Job Insecurity, and Work-Family Conflict Affect Miner Performance? Health-Anxiety and Job-Anxiety Perspectives.

The coronavirus pandemic (COVID-19) has created challenging working conditions in coal-production activities. In addition to the massive loss of resources for miners, it has had a devastating impact on these individuals' mental health. Based on the conservation of resources (COR) theory and a resource-loss perspective, this study examined the impact of COVID-19 risk, life-safety risk, perceived job insecurity, and work-family conflict on miners' job performance.

Mechanisms of cancer stem cells drug resistance and the pivotal role of HMGA2.

Nowadays, the focus of researchers is on perceiving the heterogeneity observed in a tumor. The researchers studied the role of a specific subset of cancer cells with high resistance to traditional treatments, recurrence, and unregulated metastasis. This small population of tumor cells that have stem-cell-like specifications was named Cancer Stem Cells (CSCs).

Global interest in vaccines during the COVID-19 pandemic: Evidence from Google Trends.

COVID-19 (coronavirus disease 2019) vaccines have become available; now, everyone has the opportunity to get vaccinated. We used Google Trends (GT) data to assess the global public interest in COVID-19 vaccines during the pandemic. For the analysis, a period of 17 months was chosen (from Jan 19, 2020, to Jul 04, 2021).

Economic Assessment of Permafrost Degradation Effects on Healthcare Facilities in the Russian Arctic.

The methodology and results of economic assessment and forecasting of the consequences of the most negative global climate change IPCC scenario (RCP 8.5) representative for the conditions of the Russian Arctic in the form of thawing and degradation of permafrost for healthcare facilities in eight Arctic regions of the Russian Federation are discussed. It is shown that the additional costs associated with these consequences for the maintenance and restoration of healthcare facilities in 2021-2050 may amount to about ₽60 bln, or about ₽2 bln per year (in 2021 prices) at the average rate of permafrost degradation and increase thawing depth, rising to ₽219 bln (₽7.

A Smart Healthcare Knowledge Service Framework for Hierarchical Medical Treatment System.

This paper reveals the research hotspots and development directions of case-based reasoning in the field of health care, and proposes the framework and key technologies of medical knowledge service systems based on case-based reasoning (CBR) in the big data environment. The 2124 articles on medical CBR in the Web of Science were visualized and analyzed using a bibliometrics method, and a CBR-based knowledge service system framework was constructed in the medical Internet of all people, things and data resources environment. An intelligent construction method for the clinical medical case base and the gray case knowledge reasoning model were proposed.

An Adaptive Deep Ensemble Learning Method for Dynamic Evolving Diagnostic Task Scenarios.

Increasingly, machine learning methods have been applied to aid in diagnosis with good results. However, some complex models can confuse physicians because they are difficult to understand, while data differences across diagnostic tasks and institutions can cause model performance fluctuations. To address this challenge, we combined the Deep Ensemble Model (DEM) and tree-structured Parzen Estimator (TPE) and proposed an adaptive deep ensemble learning method (TPE-DEM) for dynamic evolving diagnostic task scenarios.

Global Scientific Research on SARS-CoV-2 Vaccines: A Bibliometric Analysis.

Objective: We performed this bibliometric analysis to identify global scientific research on the SARS-CoV-2 vaccines.

Materials And Methods: This bibliometric analysis study inclusive search of English-language publications related to the SARS-CoV-2 vaccines was conducted in the Scopus, PubMed, and Dimensions databases without year limitations. The results of bibliometric analysis comprised a time-dependent citation density trend, the name of the journal, journal impact factor (IF), year of publication, type of article, category, subscription or affiliation, co-authorship, and cooccurrence network.

The Exact Definition of the Boundary between the Rapid and Slow Ejection Phases on ECGs and Accurate Location of the j Point.

Unlabelled: was to describe the boundary between the phases of rapid and slow ejection in the cardiac cycle and to define the exact location of the j point on ECGs.

Materials And Methods: The work is based on the theory of heart cycle phase analysis using mathematical equations of hemodynamics. The balance of phase diastolic and systolic blood volumes depending on the duration of the cardiac cycle phases has been verified by these equations.

A Personalized Medical Decision Support System Based on Explainable Machine Learning Algorithms and ECC Features: Data from the Real World.

Artificial intelligence can help physicians improve the accuracy of breast cancer diagnosis. However, the effectiveness of AI applications is limited by doctors' adoption of the results recommended by the personalized medical decision support system. Our primary purpose is to study the impact of external case characteristics (ECC) on the effectiveness of the personalized medical decision support system for breast cancer assisted diagnosis (PMDSS-BCAD) in making accurate recommendations.

Different Roles of Telehealth and Telemedicine on Medical Tourism: An Empirical Study from Azerbaijan.

With the rapid progress in mobile healthcare and Internet medicine, the impact of telehealth and telemedicine on the satisfaction of patients and their willingness to travel has become a focus of the academic research community. This study analyses the differences between telehealth and telemedicine and their role in medical tourism. We examine how the information quality and communication quality of telehealth and telemedicine influence patient satisfaction, and their effects on patients' willingness to undertake medical travel and on their medical travel behaviours.

A Deep Insight Into CAR-T Cell Therapy in Non-Hodgkin Lymphoma: Application, Opportunities, and Future Directions.

Non-Hodgkin's lymphoma (NHL) is a cancer that starts in the lymphatic system. In NHL, the important part of the immune system, a type of white blood cells called lymphocytes become cancerous. NHL subtypes include marginal zone lymphoma, small lymphocytic lymphoma, follicular lymphoma (FL), and lymphoplasmacytic lymphoma.

The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses.

The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV.

Simulation of Transit Transportation along the Northern Sea Route under Climate Change.

The article examines the problems and development prospects for the international transit of goods along the NSR. The existing restrictions on increasing freight traffic up to 80 million tons per year declared in program documents are identified. An option for its enhancement based on the domestic fleet of Arctic cargo ships is proposed.

Tracking Knowledge Evolution Based on the Terminology Dynamics in 4P-Medicine.

The accelerating evolution of scientific terms connected with 4P-medicine terminology and a need to track this process has led to the development of new methods of analysis and visualization of unstructured information. We built a collection of terms especially extracted from the PubMed database. Statistical analysis showed the temporal dynamics of the formation of derivatives and significant collocations of medical terms.