First Clinical Case of Ilizarov Femur Lengthening over a Bioactive and Degradable Intramedullary Implant.

Introduction: The Ilizarov distraction osteogenesis is a recognized method of limb lengthening in orthopaedic practice. Its most challenging problems are long duration of external fixation and related pin-tract infection and joint contractures. The solution might be the use of a bioactive degradable intramedullary implant stimulating bone healing.

Impact of telescopic intramedullary rodding on the growth of tibia: Comparative experimental study in dogs.

Introduction: The most commonly accepted method of long bone deformity correction in children with osteogenesis imperfecta is surgical realignment with transphyseal telescopic intramedullary rodding. This approach ensures reinforcement of the bone throughout the growth period. Although longitudinal growth does occur with these implants there has been very little work carried out to calculate the effect of such factors as rod position or implant material on growth.

Preliminary Results of Bone Lengthening over Telescopic Titanium Intramedullary Rod.

Background: Limb lengthening and deformity correction in patients with abnormal bone associating fragility often require an approach combining methods of external and internal fixation. This study demonstrates results of simultaneous application of external fixator, and telescopic rod for femoral lengthening and deformity correction in three children with osteogenesis imperfecta or severe form of Ollier's disease.

Materials And Methods: Three patients (two boys with Ollier's disease and a girl with osteogenesis imperfecta, type I) were operated on for femoral lengthening with combined technique associating Ilizarov frame and titanium telescopic intramedullary rodding.

Influence of ß-lactam antibiotics on the activity of K. pneumoniae bacteria biofilm forms isolated from wounds of patients with chronic osteomyelitis.

One of the reasons for the emergence of highly resistant strains is associated with the ability of bacteria to form biofilms on various surfaces. The formation of a biofilm by pathogens leads to a decrease in the activity of the antibiotic, an increase in the time for the production of stress response genes by bacteria, and, as a result, an increase in antimicrobial tolerance. To investigate the effect of imipenem and cefepime on the activity of biofilm forms of K.

Efficacy of cephalosporins against enterobacteria isolated from patients with chronic osteomyelitis.

Long-term antibiotic therapy, as well as inappropriate use of drugs in the treatment of osteomyelitis, can lead to the appearance of pan-resistant strains. The existing antibiotic prophylaxis regimens for purulent-septic complications are outdated and need to be adjusted. In this regard, it is necessary to monitor the resistance of microorganisms in order to identify ineffective antibacterial drugs.

Solution blow spinning of PLLA/hydroxyapatite composite scaffolds for bone tissue engineering.

Composite poly-L-lactide acid-based scaffolds with hydroxyapatite (HAp) content up to 75 wt.% were fabricated via solution blow spinning. The influence of HAp concentration on structure, wettability, mechanical properties and chemical and phase composition of the produced materials was examined.

Nonunion of the femoral shaft associated with limb shortening treated with a combined technique of external fixation over an intramedullary nail versus the Ilizarov method.

Introduction: Post-traumatic nonunion of the femur remains a challenging problem even for experienced orthopedic surgeons. The main question is the choice of the optimal surgical tool.

Materials And Methods: Management of 20 patients with nonunion of the femoral diaphysis associated with anatomical shortening was retrospectively analyzed.

Reconstruction by ilizarov technique for sequelae of pediatric hip septic coxitis: A case study of a new technique with 14 years follow-up.

Pediatric septic hip sequelae represent a challenging condition to the treating surgeons with conventional femoral and pelvic osteotomy being difficult to solve advanced head and neck destruction. Surgeons usually resolve to pelvic support osteotomy which is technically demanding and may require revision if performed before skeletal maturity. We report a 10 years old girl which had sequelae of septic coxitis Hunka type IVb, the patient was treated by a C-shaped pertrochanteric and Salter osteotomy and by applying Ilizarov methods of distraction histogenesis we did reduction and gradual lengthening of the femoral neck stump which was adapted to the acetabular cavity at last assessment, the clinical and radiographic parameters had improved significantly at 14 years long term follow-up and the patient was able to walk painlessly and without support.

[Comparative assessment of mineral metabolism in shoulders and crura in patients with osteomyelitis.].

Chronic osteomyelitis in long tubular bones is generally aggravated by metabolic imbalance in patients' organisms affecting mineral metabolism. It is critically important that the extent of this imbalance should be determined prior to surgical intervention to choose optimal methodology, proper monitoring of recovery and adequate prognostication of final results. With this in mind a comparative assessment has been carried out to shed light on the intensity of mineral metabolism in the blood serum of patients suffering from osteomyelitis in their shoulders and crura.

[The influence of endodontic rinsing liquids activation methods on the root dentin structure and effectiveness of root canal cleaning].

The study was aimed to conduct a morphological assessment of the influence exerted by a certain method of activation of endodontic rinsing liquid on the root dentin structure and canal cleaning effectiveness in an ex vivo experiment. The study was performed on 20 single-rooted teeth removed due to complicated caries in people aged 25-44 years. A devised method of vacuum-jet irrigation was used to carry out the final antiseptic treatment and to activate a rinsing liquid in the group No.

Lower limb lengthening and deformity correction in polyostotic fibrous dysplasia using external fixation and flexible intramedullary nailing.

Unlabelled: The study describes preliminary experience of the use of external fixators for limb lengthening and deformity correction in combination with flexible intramedullary nailing in management of polyostotic fibrous dysplasia.

Patients And Methods: The retrospective study included 8 patients (mean age 11.6 ± 3.

Closed arthrodesis in infected neuropathic ankles using Ilizarov ring fixation.

Aims: Infected and deformed neuropathic feet and ankles are serious challenges for surgical management. In this study we present our experience in performing ankle arthrodesis in a closed manner, without surgical preparation of the joint surfaces by cartilaginous debridement, but instead using an Ilizarov ring fixator (IRF) for deformity correction and facilitating fusion, in arthritic neuropathic ankles with associated osteomyelitis.

Methods: We retrospectively reviewed all the patients who underwent closed ankle arthrodesis (CAA) in Ilizarov Scientific Centre from 2013 to 2018 (Group A) and compared them with a similar group of patients (Group B) who underwent open ankle arthrodesis (OAA).

[Perthes disease: immunological aspects.].

The values of cellular, humoral immunity, cytokine status, those of phagocytic activity of neutrophils (PAN) have been studied in patients with Perthes disease II and III Stages. Considering a stage of the pathological process patients (boys at the age of 8-12 years) were divided into two (2) groups. Group I included 14 patients with the fragmentation stage (Perthes disease Stage II).

[Dynamics of hemogram indicators in children with pathology of the hip joint before and after treatment by the Ilizarov method.].

The pathology of the hip joints in children is the object of increased attention of specialists both in our country and abroad. Despite the wide coverage of this problem, most studies are devoted to analysis of the advantages of various surgical intervention technologies. To determine the significance of differences in hemogram indices in children with different nosological forms of hip joint pathology and indicators of healthy children.

[Dependence of biofilm-forming ability on the antibiotic sensitivity of Pseudomonas aeruginosa clinical strains isolated from patients with chronic osteomyelitis.].

Due to the spreading highly resistant strains among clinically significant P. aeruginosa clones, it becomes necessary to prescribe antibiotics not only taking into account the knowledge of sensitivity spectrum of a particular isolate but the data of microorganism biofilm activity as well. To study the dependence of biofilm-forming ability on the sensitivity to antibacterial preparations of P.

Combined technique with hydroxyapatite coated intramedullary nails in treatment of anterolateral bowing of congenital pseudarthrosis of tibia.

Purpose: The goal of this study is to evaluate the treatment outcomes of anterolateral bowing and residual deformities of distal tibia in patients with CPT using circular external fixation and hydroxyapatite coated flexible intramedullary nailing without excision of affected part of tibia.

Patients And Methods: Six patients (4 boys and 2 girls, mean age 12.4 ± 4.

[The effect of age on the degree of strength restoration of the lower limb musles in the long-term period after surgical treatment of adult patients with spondylolisthesis.].

The purpose of the work was to study the effect of age on the degree of isometric strength restoration of the lower limb muscles in the long-term period after surgical treatment of adult patients with spondylolisthesis. 36 patients with spondylolisthesis of I and II displacement degree and 50 normal subjects at the age of 41-66 years were included in the study. Maximum moments of the femur and leg isometric strength were studied using dynamometric stands.

[Microflora of surgical wounds and fistulas in patients with chronic osteomyelitis of the tibia before reconstructive treatment, in case of recurrence of infection.].

Relevance of microbiological monitoring in chronic osteomyelitis of the tibia developed during treatment of fractures with a plate is associated with a noticeable increase of various kinds of the microflora. A microbiological study was conducted of pathological material taken from wounds, fistulas and from the focus of inflammation in 49 patients with chronic tibial osteomyelitis, developed during treatment of fractures with a plate. The patients underwent sequestrectomy of the tibia and subsequent application of bilocal consecutive compression-distraction osteosynthesis or monolocal compression osteosynthesis.

[Oxygen-dependent mechanisms and oxidative stress in children for femoral head osteochondropathy.].

Degenerative-dystrophic processes in the articular tissues are accompanied by the changes in the values of congenital immunity, being a result of immune responses to aseptic inflammation. The purpose of this study - to investigate the oxygen-dependent mechanisms of neutrophil phagocytic activity (NBT-test, myeloperoxidase activity), the biochemical values of lipid peroxidation, the oxidative modification of proteins and the activity of enzyme antioxidant protection in children (at the age of 12-16 years) with osteochondropathy of the femoral head.The increase in spontaneous NBT-test and myeloperoxidase content in neutrophils, the decrease in NBT stimulation index, as well as the statistically significant increase in the activity of superoxide dismutase, the main producer of hydroperoxide, was revealed in the group examined.

[Quantitative characterization of risk of iatrogenic damage to pyramidal tracts based on data of intraoperative neuromonitoring during surgical correction of spinal deformities].

Objective: Development of a quantitative indicator for the risk level of intraoperative iatrogenic motor disorders in the process of surgical correction of spinal deformity based on current neurophysiological monitoring data.

Material And Methods: 288 patients 12.6±0.

Treatment of forearm diaphyseal defect by distraction compression bone transport and continued distraction for radial head reduction: A case study.

Treatment of infected forearm nonunion and defects represents a difficult task for the operating surgeons. Conventional methods like composite and vascularized fibular grafts and the induced membranes filled with cancellous autografts or the Masquelet technique have been reported to be useful and successful, but sometimes it is difficult to predict the outcome and cannot address simultaneous deformities or the need to apply gradual distraction for reduction of a chronically dislocated radial head. Ilizarov technique has an answer for such conditions.

Vertical Wire Forefoot Fixation: An Advanced Technique for the Dynamic External Fixation Apparatus.

External fixation is used for the correction of select foot and ankle deformities. We have found the traditional forefoot crossing wire technique to be insufficient in terms of both individual metatarsal control and forefoot manipulation when using a dynamic ring fixator to correct forefoot deformities. We developed a forefoot fixation technique at the University of Cincinnati Medical Center, using 5 vertical wires to gain greater forefoot control while performing more precise skeletal manipulation for multiplanar deformity correction.

Radiomorphological Manifestations of Femoral and Tibial Cortical Bones at Different Stages of Limb Lengthening.

Background: There has been a lot of research done on Ilizarov's limb lengthening; however, very few publications focus on the quantitative assessment of the distractional bone regeneration in tibial and femur lengthening. Data regarding quality of the bone after lengthening are needed to consider the time of frame removal and develop a rehabilitation program.

Materials And Methods: Computed tomography (CT) assessment of a parent bone was performed on 136 patients with limb length discrepancy and bone deformity of various etiologies before and after lengthening.

Applicability of histopathological osteomyelitis evaluation score (HOES) in chronic osteomyelitis of the foot - A feasibility study.

Background: Diagnosis and classification of chronic osteomyelitis is not based on any objective criteria. None of the available methods for this is completely reliable. Tienmann et al.

Limb lengthening and deformity correction in children with abnormal bone.

Flexible intramedullary nailing (FIN) provides multiple advantages in limb lengthening and progressive deformity correction in combination with external fixation. The article presents brief literature review and authors' experience in limb lengthening of abnormal bone (Ollier's disease, fibrous dysplasia, osteogenesis imperfecta). Titanium and, especially, hydroxyapatite-coated bent elastic nails in combination with external fixator are appropriate in limb lengthening of abnormal bone in children.