Composite Sorbents Based on Chitosan Polymer Matrix and Derivatives of 4-Amino-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide for Uranium Removal from Liquid Mineralized Media.

Composite adsorbents based on a natural biopolymer matrix of chitosan, to which 4-amino-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide and its Se derivative were attached, were synthesized. A complex of physicochemical analysis methods indicates that the direct introduction of a matrix with high ionic permeability into the reaction mixture contributes to the formation of homogeneous particles of composite with developed surface morphology, which enhances the kinetic and capacitive parameters of uranium sorption in liquid media. It has been established that the direct introduction of a matrix with high ionic permeability into the reaction mixture contributes to the formation of homogeneous particles with a developed surface morphology, which enhances the kinetic and capacitive parameters of uranium sorption in liquid media.

Composite Sorbents Based on Polymeric Se-Derivative of Amidoximes and SiO for the Uranium Removal from Liquid Mineralized Media.

A new composite material with enhanced sorption-selective properties for uranium recovery from liquid media has been obtained. Sorbents were synthesized through a polycondensation reaction of a mixture of 4-amino-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (hereinafter referred to as amidoxime) and SiO in an environment of organic solvents (acetic acid, dioxane) and highly porous SiO. To establish optimal conditions for forming the polymer sorption-active part and the synthesis as a whole, a series of composite adsorbents were synthesized with varying amidoxime/matrix ratios (35/65, 50/50, 65/35).

Texture Perception and Chewing of Agar Gel by People with Different Sensitivity to Hardness.

Hardness is one of the dominant sensory characteristics of food. This study estimated the effect of sensitivity to hardness on the texture perception and chewing function using 2, 4, and 6% agar gels. Increasing the concentration of agar resulted in an increase in gel hardness and springiness, measured by texture profile analysis.

Morphology of Graphene Aerogel as the Key Factor: Mechanical Properties Under Tension and Compression.

Graphene aerogels with high surface areas, ultra-low densities, and thermal conductivities have been attracted a lot of attention in recent years. However, considerable difference in their deformation behavior and mechanical properties lead to their poor performance. The problem can be solved by preparing graphene aerogel of given morphology and by control the properties through the special structure of graphene cells.

A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review.

Introduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of brain tumors and vary in aggressiveness from grade I to IV. Despite advancements in neuroimaging and surgical techniques, their management remains complex due to their location near critical cognitive areas. Techniques like awake craniotomy have improved outcomes, but tumor heterogeneity and proximity to vital structures pose challenges.

Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study.

Background: The RAVE-Renal study was conducted to evaluate the real-world efficacy and safety of avelumab plus axitinib as a first-line therapy for patients with metastatic renal cell carcinoma (mRCC).

Methods: RAVE-Renal was a multicenter, noninterventional, ambispective study with both retrospective and prospective components. The study included adult patients with histologically confirmed mRCC, measurable disease per RECIST version 1.

Loneliness in Middle-Aged and Older Adults: Effects of Social Environments.

Loneliness is a common subjective condition that is associated with distress and negative outcomes for psychosocial functioning and well-being, and it is grounded in destructive or inadequate social functioning. Social interactions are considered one of the key factors determining loneliness, and similarly to social interactions, loneliness can occur in different domains. While a solid body of research is focused on loneliness as a general condition, there are few studies that investigate loneliness from a multidimensional perspective, particularly combining general and domain-specific loneliness.

Distinguishing Ideal and Non-Ideal Chemical Systems Based on Kinetic Behavior.

This paper focuses on differentiating between ideal and non-ideal chemical systems based on their kinetic behavior within a closed isothermal chemical environment. Non-ideality is examined using the non-ideal Marcelin-de Donde model. The analysis primarily addresses 'soft' non-ideality, where the equilibrium composition for a reversible non-ideal chemical system is identical to the corresponding composition for the ideal chemical system.

Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus.

Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate early genes (IEGs) that regulate neuronal activity, thereby supporting learning and memory.

Fluorescence Lifetime Imaging of NAD(P)H in Patients' Lymphocytes: Evaluation of Efficacy of Immunotherapy.

Background: The wide variability in clinical responses to anti-tumor immunotherapy drives the search for personalized strategies. One of the promising approaches is drug screening using patient-derived models composed of tumor and immune cells. In this regard, the selection of an appropriate in vitro model and the choice of cellular response assay are critical for reliable predictions.

Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice.

Traumatic brain injury (TBI) is one of the major causes of severe neurological disorders and long-term dysfunction in the nervous system. Besides inducing neurodegeneration, TBI alters stem cell activity and neurogenesis within primary neurogenic niches. However, the fate of dividing cells in other brain regions remains unclear despite offering potential targets for therapeutic intervention.

Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy.

In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells.

Resistance to Radiotherapy in Cancer.

Radiation therapy or radiotherapy is a medical treatment that uses high doses of ionizing radiation to eliminate cancer cells and shrink tumors. It works by targeting the DNA within the tumor cells restricting their proliferation. Radiotherapy has been used for treating cancer for more than 100 years.

Robotic Surgery from a Gynaecological Oncology Perspective: A Global Gynaecological Oncology Surgical Outcomes Collaborative Led Study (GO SOAR3).

Background/objectives: For healthcare institutions developing a robotic programme, delivering value for patients, clinicians, and payers is key. However, the impact on the surgeon, training pathways, and logistics are often overlooked. We conducted a study on the impact of robotic surgery on surgeons, access to robotic surgical training, and factors associated with developing a successful robotic programme.

Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning.

Electroretinograms (ERGs) show differences between typically developing populations and those with a diagnosis of autism spectrum disorder (ASD) or attention deficit/hyperactivity disorder (ADHD). In a series of ERGs collected in ASD ( = 77), ADHD ( = 43), ASD + ADHD ( = 21), and control ( = 137) groups, this analysis explores the use of machine learning and feature selection techniques to improve the classification between these clinically defined groups. Standard time domain and signal analysis features were evaluated in different machine learning models.

Modeling of Jet Lag and Searching for an Optimal Light Treatment.

The role of the hierarchical organization of the suprachiasmatic nucleus (SCN) in its functioning, jet lag, and the light treatment of jet lag remains poorly understood. Using the core-shell model, we mimic collective behavior of the core and shell populations of the SCN oscillators in transient states after rapid traveling east and west. The existence of a special region of slow dynamical states of the SCN oscillators can explain phenomena such as the east-west asymmetry of jet lag, instances when entrainment to an advance is via delay shifts, and the dynamics of jet lag recovery time.

Targeted correction of megabase-scale duplication in induced pluripotent stem cells and impacts on gene expression.

Copy number variations of the human gene, resulting from megabase-scale microdeletions or microduplications in the 3p26.3 region, are frequently implicated in neurodevelopmental disorders such as intellectual disability and developmental delay. However, duplication of the full-length human gene presents with variable penetrance, resulting in phenotypes that range from neurodevelopmental disorders to no visible pathologies, even within the same family.

Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer.

Background: The natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs) is a crucial defense against the onset and spread of cancer. Studies have shown that patients with reduced NK activity are more susceptible to cancer, and NK activity tends to decrease due to cancer-induced immune suppression. Enhancing the natural cytotoxicity of PBMCs remains a significant task in cancer research.

Periodontal pathogens and obesity in the context of cardiovascular risks across age groups.

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity among noncommunicable diseases. Over the past decade, there has been a notable increase in the prevalence of CVDs among young individuals. Obesity, a well-known risk factor for CVDs, is also associated with various comorbidities that may contribute to cardiovascular risk.

Clinical case of co-infection: Dengue fever and respiratory mycoplasmosis in a child.

According to WHO, dengue fever (DF) is currently endemic to more than 100 countries in various regions of Africa, America, and Asia; outbreaks have been reported in Europe. In the Russian Federation, there is a much smaller proportion of children among those infected due to the imported nature of the infection. We described a clinical case of imported dengue fever in an adolescent girl in Moscow after a 5-day vacation.

Soybean protein isolate/dialdehyde sodium alginate hydrogels based on dynamic imine bond cross-linking: Synthesis and properties.

A soybean protein isolate (SPI)-based hydrogel with controllable properties was prepared under mild conditions using a simple mixing method with dialdehyde sodium alginate (DSA) as an eco-friendly macromolecular crosslinker. DSA was successfully synthesized via periodate oxidation. Analysis of the structure of the SPI/DSA hydrogel indicated that a 3D network was formed between SPI and DSA through dynamic imine and hydrogen bonds.

Remodeling the light-adapted electroretinogram using a bayesian statistical approach.

Objective: To present a remodeling of the electroretinogram waveform using a covariance matrix to identify regions of interest and distinction between a control and attention deficit/hyperactivity disorder (ADHD) group. Electroretinograms were recorded in n = 25 ADHD (16 male; age 11.9 ± 2.

BAC-browser: the tool for synthetic biology.

Background: Currently, synthetic genomics is a rapidly developing field. Its main tasks, such as the design of synthetic sequences and the assembly of DNA sequences from synthetic oligonucleotides, require specialized software. In this article, we present a program with a graphical interface that allows non-bioinformatics to perform the tasks needed in synthetic genomics.

Characteristics of salt dust aerosols and their transport implications in the Aral Sea.

Central Asia is an ecologically fragile arid zone and a typical mixed salt‒sand region. The socioeconomic and ecological problems attributed to the shrinking of the Aral Sea in Central Asia are notable concerns within the international community. In this study, the characteristics of salt dust aerosols from the Aral Sea were analysed to explore their interannual variation characteristics and analyse the spatial and temporal distributions of salt dust sources and transport and dispersion pathways.