[Indirect comparison of anti-angiogenic agents in the treatment of diabetic macular edema].

Unlabelled: Diabetic macular edema (DME) is a leading cause of visual impairment and blindness among diabetic patients, its prevalence is continuing to increase worldwide. Faricimab, a bispecific antibody, represents a new generation of treatments for DME.

Purpose: This study presents an indirect comparison of the effectiveness and safety of faricimab versus other treatment options for DME.

[The role of some inflammatory markers in diagnosis of acute peritonitis in patients with HIV infection].

Objective: To evaluate the effectiveness of leukocyte, NLR, procalcitonin and C-reactive protein as the markers of acute peritonitis in patients with HIV-infection.

Material And Methods: The study included 83 HIV-infected patients with various diseases complicated by acute peritonitis. Leukocytes, procalcitonin and C-reactive protein, as well as immune status and viral load were determined in peripheral blood before surgery.

[ArdA Protein Specificity against Type I Restriction-Modification Systems].

The ArdA DNA-mimic antirestriction proteins inhibit type I restriction-modification (RMI) systems by binding instead of DNA to RMI. The ArdA specificity to DNA methylation sites recognized by RMI complexes remains poorly understood; i.e.

Epigenetic Alterations in Post-Traumatic Stress Disorder: Comprehensive Review of Molecular Markers.

Background: Post-traumatic stress disorder (PTSD) can occur after a traumatic event. PTSD is characterized by nightmares, flashbacks and avoidance of stressors. It currently affects 2-8% of the population, with military personnel particularly susceptible.

[Combined prevention of infectious complications of minimally invasive procedures in urology].

The available literature data on the prevention of infectious and inflammatory complications after minimally invasive urological procedures based on current knowledge about urobiome as the main point of application of preventive measures are summarized in the article. The main risk factors for the occurrence of inflammatory complications at all stages of the perioperative process are analyzed. The role of antibacterial prophylaxis is emphasized, and its features and the importance of finding ways to overcome one of the main problems of modern medicine, which is antibiotic resistance, are discussed.

[MALIGNANT NEOPLASMS OF THE REPRODUCTIVE SYSTEM IN MEN AND THEIR CONNECTION WITH THE HUMAN PAPILLOMAVIRUS. (REVIEW)].

The issue of malignant tumor occurrence associated with viral infections is a particularly significant one. Approximately 15-20% of tumors have some connection with various viral infections. An extensive amount of data has been gathered on neoplasms of the female reproductive system linked to the human papillomavirus (HPV).

EEG Techniques with Brain Activity Localization, Specifically LORETA, and Its Applicability in Monitoring Schizophrenia.

: Electroencephalography (EEG) is considered a standard but powerful tool for the diagnosis of neurological and psychiatric diseases. With modern imaging techniques such as magnetic resonance imaging (MRI), computed tomography (CT), and magnetoencephalography (MEG), source localization can be improved, especially with low-resolution brain electromagnetic tomography (LORETA). The aim of this review is to explore the variety of modern techniques with emphasis on the efficacy of LORETA in detecting brain activity patterns in schizophrenia.

Dynamics of Cognitive Impairment in MCI Patients over a Three-Year Period: The Informative Role of Blood Biomarkers, Neuroimaging, and Genetic Factors.

Given the high growth rates of cognitive decline among the elderly population and the lack of effective etiological treatments, early diagnosis of cognitive impairment progression is an imperative task for modern science and medicine. It is of particular interest to identify predictors of an unfavorable subsequent course of cognitive disorders, specifically, rapid progression. Our study assessed the informative role of various risk factors on the dynamics of cognitive impairment among mild cognitive impairment (MCI) patients.

Nanoparticles of dust as an emerging contaminant in urban environments.

Due to very high mobility in the environment and penetration ability into living organisms, nanoparticles (NPs) of urban dust pose a potential threat to human health and urban ecosystems. Currently, data on the chemical composition of NPs of urban dust, their fate in the environment, and corresponding risks are rather limited. In the present work, NPs of deposited urban dust have been comprehensively studied for the first time; NPs isolated from 78 samples of dust collected in Moscow, the largest megacity in Europe, being taken as example.

The Study of TRPV1 Channels of the Central Nervous System and Their Effect on Anxiety in ICR Mice.

The TRPV1 channel is actively involved in various neuronal processes and is found in various structures of the nervous system, including peripheral and central neurons, sensory ganglia, spinal cord, and various parts of the brain. Due to its ability to respond to various stimuli, TRPV1 can have a significant impact on the body's responses to stress. Studies indicate the involvement of TRPV1 in the regulation of anxiety behavior.

Proteomic and transcriptomic analyses of biofilms and planktonic cultures in presence of epinephrine.

Transcriptomic and proteomic analysis were performed on 72 h biofilms of the acneic strain and planktonic cultures in the presence of epinephrine. Epinephrine predominantly downregulated genes associated with various transporter proteins. No correlation was found between proteomic and transcriptomic profiles.

Assessment of Phytomass and Carbon Stock in the Ecosystems of the Central Forest Steppe of the East European Plain: Integrated Approach of Terrestrial Environmental Monitoring and Remote Sensing with Unmanned Aerial Vehicles.

The rapid and accurate estimation of aboveground forest phytomass remains a challenging research task. In general, methods for estimating phytomass fall mainly into the category of field measurements performed by ground-based methods, but approaches based on remote sensing and ecological modelling have been increasingly applied. The aim is to develop the scientific and methodological framework for the remote sensing estimation of qualitative and quantitative characteristics of forest stands, using the combination of surveys and machine learning models to determine phytomass of forest stands and calculate the carbon balance.

[Long-term consequences of COVID-19 in patients with functional bowel disorders, rehabilitation prospective of microbiocenosis-oriented therapy].

Aim: To analyze long-term consequences of the new coronavirus infection and rehabilitation prospective of microbiocenosis-oriented therapy in patients with functional bowel disorders.

Materials And Methods: The study enrolled 100 consecutive patients with various types of functional bowel disorders with recurrence of symptoms after the new coronavirus infection. The severity of abdominal pain was evaluated in points, and bowel movement disorders were assessed using the Bristol stool scale.

[Improving the effectiveness of local anesthesia in patients with arterial hypertension in the provision of emergency dental care].

The Aim Of The Study: Was to evaluate the use of Ketorol Express as a preventive analgesia to increase the effectiveness of local anesthesia in providing emergency dental care to patients with arterial hypertension.

Materials And Methods: The study was conducted on the basis of the state autonomous healthcare institution of the Moscow region «Royal Dental Clinic» with the participation of 83 people. The patients were divided into two groups.

Experimental Approaches to Scar Modeling through Mechanical Skin Damage and Chemical Burn in Sprague Dawley Rats.

Creating of a scar model in laboratory animals is the most acceptable option for the preclinical search of scar treatment. However, due to high skin regeneration rate in laboratory rodents, creating an optimal animal model of scar formation is a challenge. Here we describe five methods for modeling a scar tissue in rats that we have tested.

Radioprotective Properties of Riboxin (Inosine) and Indralin under External Irradiation.

A comparative assessment of radioprotective properties of inosine nucleoside (riboxin) and recognized radioprotector indralin was carried out. We analyzed survival of male ICR CD-1 mice weighting 32.2±0.

Anatomical, pathological, and histological features of experimental respiratory infection of birds by biofilm-forming bacteria .

Background And Aim: The pathogenesis of staphylococcal infections is mediated by virulence factors, such as enzymes, toxins, and biofilms, which increase the resistance of microorganisms to host immune system evasion. Testing and searching for standardized multi-level algorithms for the indication and differentiation of biofilms at the early stages of diagnosis will contribute to the development of preventive measures to control the critical points of technology and manage dangerous risk factors for the spread of infectious diseases. This research aimed to study the main stages of s biofilm formation in experiments and to analyze the dynamics of respiratory syndrome development in chickens infected with these bacteria.

Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice.

Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were kept on a high-fat diet for 21 weeks. The animals showed a significant increase in fasting and postprandial glucose levels and body weight, the development of insulin resistance, and by week 18, an increase in the serum TNFα level.

[Autoimmune encephalitis: psychiatric aspects].

Autoimmune encephalitis is a group of diseases researched by both neurologists and psychiatrists. Despite a large number of studies and practical recommendations, the differential diagnosis and early diagnostics still remains an important issue. The most difficult to diagnose are cases that debut as mental disorders and/or occur without neurological symptoms.

[Fluorescence lymphography for sentinal lymph node biopsy in breast cancer].

Objective: To study diagnostic value of fluorescence lymphography for sentinel lymph node biopsy in breast cancer.

Material And Methods: The study enrolled 25 patients with breast cancer T1-2N0-1M0 between March 2023 and July 2023. Eight ones underwent neoadjuvant chemotherapy.

[Efficacy and safety of bacterial lysate OM-85 in the treatment of uncomplicated acute respiratory infections: a double-blind, placebo-controlled, multicenter, randomized trial].

Aim: To evaluate the efficacy and safety of OM-85 in the treatment of uncomplicated acute respiratory infections (ARI) in adults.

Materials And Methods: A double-blind, placebo-controlled, multicenter, randomized trial included 556 patients (18-60 years old) with mild and moderate ARI and negative results of polymerase chain reaction analysis for SARS-CoV-2 RNA and rapid test for influenza A and B viruses. Patients were randomized into two groups: in the first group (278), patients received OM-85 (Broncho-munal) one capsule 7 mg/day for 10 days, while the second group (278) was treated with placebo in the same regimen.

[Acute bronchitis - modern possibilities of mucactive therapy].

Aim: Analysis of the clinical effectiveness and safety of erdosteine use in comparison with standard (real practice) mucoactive therapy in patients with acute bronchitis (АВ) in adults.

Materials And Methods: The observational program included 100 adult patients with АВ, 50 of them (group 1) received erdosteine, the group 2 also included 50 patients who received acetylcysteine, bromhexine and other mucolytics (real clinical practice). The following were assessed: cough severity, average time for resolution of night and daytime cough, satisfaction with treatment, NO concentration in exhaled air, levels of C-reactive protein (CRP) and interleukin-6 (IL-6).