The first experimentally obtained dataset on processing parameters and properties of soft magnetic composites.

The present work describes the process of the creation and analysis of the first dataset containing processing parameters and functional properties of soft magnetic composites (SMC). All data were obtained experimentally using Fe-3% MgO system. When creating samples, parameters such as a size of MgO nanoparticles, pressing pressure, sintering temperature, time and atmosphere were varied.

Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-microbial Peptides: a Comprehensive Review.

Antimicrobial peptides (AMPs) are small, positively charged biomolecules produced by various organisms such as animals, microbes, and plants. These AMPs play a significant role in defense mechanisms and protect from adverse conditions. The emerging problem of drug resistance in microbes poses a global health challenge in treating diseases.

Pharmacological targeting of caspase-8/c-FLIP heterodimer enhances complex II assembly and elimination of pancreatic cancer cells.

Extrinsic apoptotic network is driven by Death Ligand (DL)-mediated activation of procaspase-8. Recently, we have developed the first-in class small molecule, FLIPinB, which specifically targets the key regulator of extrinsic apoptosis, the protein c-FLIP, in the caspase-8/c-FLIP heterodimer. We have shown that FLIPinB enhances DL-induced caspase-8 activity and apoptosis.

Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial.

Background: The impact of noninvasive ventilation (NIV) managed outside the intensive care unit in patients with early acute respiratory failure remains unclear. We aimed to determine whether adding early NIV prevents the progression to severe respiratory failure.

Methods: In this multinational, randomised, open-label controlled trial, adults with mild acute respiratory failure (arterial oxygen partial pressure/fraction of inspiratory oxygen [Pao/FiO] ratio ≥200) were enrolled across 11 hospitals in Italy, Greece, and Kazakhstan.

Optimizing combination targeted immunotoxin therapy: Insights from HER2 and EpCAM expression profiles.

Molecular targeted cancer therapy is a rapidly developing field, driving progress toward greater treatment efficacy. However, targeted monotherapy often fails due to the development of multidrug resistance in tumors. The combination of multiple targeted agents emerges as a possible solution to enhance treatment outcomes by activating different signaling pathways.

Contrasting effects of arsenic on mycorrhizal-mediated silicon and phosphorus uptake by rice.

Silicon (Si) and arbuscular mycorrhizal fungi (AMF) increase plant resistance to various environmental stresses, including heavy metal (and metalloid) toxicity. Although Si and AMF each independently enhance plant tolerance, the nature of their interactions and their combined impacts on nutrient uptake, especially in the context of toxic elements such as arsenic (As), remains to be elucidated. This study investigated AMF-mediated regulation of plant nutrient uptake under As stress using rice, a model Si-accumulating plant.

Electrocardiographic marker of ventricular action potential triangulation (the simulation study).

Background: The aim of this simulation was to examine the utility of a novel ECG-based index of cardiac action potential (AP) triangulation, the Tstart-to-Tpeak (TsTp) interval-to-JTstart (JTs) interval ratio, for assessment of changes in AP profile imposed through variations in the duration of the plateau phase and the phase 3 repolarization.

Methods: ECGs were simulated using a realistic rabbit model based on experimental data. The AP plateau was measured at APD30, and the phase 3 was assessed as APD90-to-APD30 difference (AP durations at 90 % and 30 % repolarization, respectively).

Variability of Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) thresholds in psoriatic arthritis: data from the ReFlaP study.

Objectives: To explore thresholds for the Psoriatic Arthritis (PsA) Impact of Disease questionnaire (PsAID12) score against disease activity measures in an observational setting, in patients with PsA.

Methods: The baseline data from the ReFlaP observational, prospective, multicentre and international study was used (NCT03119805). Cutoffs for PsAID12 were determined against disease activity scores, defining disease impact states (ie remission, low impact, moderate impact and high impact).

Laser speckle contrast imaging with principal component and entropy analysis: a novel approach for depth-independent blood flow assessment.

Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By combining LSCI and laser speckle entropy imaging with PCA filtering, the method effectively separates static and dynamic components of the speckle signal, significantly improving the accuracy of blood flow assessments, even in the presence of static scattering layers located above and below the vessel. Experiments conducted on optical phantoms, with the vessel depths ranging from 0.

Extracellular phospholipase, protease and hemolysin production by strains of opportunistic yeasts from the excreta of Mew Gulls breeding in natural and urban habitats.

Extracellular hydrolytic activity (phospholipase, protease and hemolysin production) was evaluated in 178 strains of potentially pathogenic ascomycetous (Candida parapsilosis, Candida tropicalis) and basidiomycetous (Rhodotorula mucilaginosa) yeasts isolated from the excreta of Mew Gulls. Two bird colonies, one nesting in a natural habitat and the other in an urban habitat at the landfill, were studied simultaneously during their 7-month breeding season. Significant differences in phospholipase and protease production were found between natural and anthropophized strains.

Basic Science and Pathogenesis.

Background: Dementia aggravates most cerebrovascular lesions, which requires differentiating the developed microcirculatory changes when making a diagnosis. We consider the features of cerebral microcirculation disorders in Alzheimer's disease (AD), distal cerebral atherosclerosis, Binswanger's disease (BD), and vascular parkinsonism (VP).

Method: The study included 1024 patients who underwent: assessment of CDR, TDR, MMSE, cerebral MRI, MRA, CT, MSCTA, scintigraphy (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA).

Optical Excitation of Coherent THz Dynamics of the Rare-Earth Lattice through Resonant Pumping of f-f Electronic Transition in a Complex Perovskite DyFeO_{3}.

Resonant pumping of the electronic f-f transitions in the orbital multiplet of dysprosium ions (Dy^{3+}) in a complex perovskite DyFeO_{3} is shown to impulsively launch THz lattice dynamics corresponding to the B_{2g} phonon mode, which is dominanted by the motion of Dy^{3+} ions. The findings, supported by symmetry analysis and density-functional theory calculations, not only provide a novel route for highly selective excitation of the rare-earth crystal lattices but also establish important relationships between the symmetry of the electronic and lattice excitations in complex oxides.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Dose threshold for residual γH2AX, 53BP1, pATM and p-p53 (Ser-15) foci in X-ray irradiated human fibroblasts.

Background: Enumeration of residual DNA repair foci 24 hours or more after exposure to ionizing radiation (IR) is often used to assess the efficiency of DNA double-strand break repair. However, the relationship between the number of residual foci in irradiated cells and the radiation dose is still poorly understood. The aim of this work was to investigate the dose responses for residual DNA repair foci in normal human fibroblasts after X-ray exposure in the absorbed dose range from 0.

Flavuside B exhibits antioxidant and anti-inflammatory properties in Staphylococcus aureus infected skin wound and affect the expression of genes controlling bacterial quorum sensing.

Aims: The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of marine fungal cerebroside flavuside B (FlaB) on Staphylococcus aureus-infected keratinocytes in in vitro skin wounds and to identify FlaB targets in bacterial and human cells.

Methods And Results: A combination of ELISA, plate spectrofluorimetry, and flow cytometry with fluorescence dye staining, scratch assay, and real-time cell imaging techniques was used to investigate the effects of FlaB on S. aureus-infected HaCaT keratinocytes.

Seroprevalence of measles antibody among immigrants in Gwangju, South Korea.

Introduction: Measles remains a public health concern, particularly among populations with suboptimal vaccination coverage, including immigrants. Understanding the seroprevalence of measles antibodies in immigrant populations is essential to inform tailored vaccination strategies and reduce the risk of measles reintroduction.

Methods: This study evaluated measles IgG seroprevalence among 651 immigrants from 30 countries residing in Gwangju, South Korea.

Influence of early-life stress on hippocampal synaptic and network properties.

According to the World Health Organization, the number of people suffering from depressive disorders worldwide is approaching 350 million. The consequences of depressive disorders include considerable worsening of the quality of life, which frequently leads to social isolation. One of the key factors which may cause depression in adulthood is early life stress, in particular, insufficient maternal care during infancy.

Distinct brain systems are involved in subjective minute estimation with eyes open or closed: EEG source analysis study.

Introduction: Time perception is a fundamental cognitive function, the brain mechanisms of which are not fully understood. Recent electroencephalography (EEG) studies have shown that neural oscillations in specific frequency bands may play a role in this process. In the current study, we sought to investigate how neurophysiological activity of cortical structures relates to subjective time estimations.

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats.

Introduction: Aggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in rodents.

Elimination of nickel ions in a packed column using clamshell waste as an adsorbent.

The present investigation assessed the viability of utilizing a powdered clam shell in continuous adsorption to eliminate nickel ions from simulated wastewater. The breakthrough curves (BTC) were analyzed by altering the Q (inlet flow rate) in a glass column (ID 5 cm, H 35 cm) with a multi-port and filled with the powdered clamshell adsorbent (PCSA). The PCSA's nickel adsorption efficiency was maximum (87.

Modeling saturation exponent of underground hydrocarbon reservoirs using robust machine learning methods.

Precise estimation of rock petrophysical parameters are seriously important for the reliable computation of hydrocarbon in place in the underground formations. Therefore, accurately estimation rock saturation exponent is necessary in this regard. In this communication, we aim to develop intelligent data-driven models of decision tree, random forest, ensemble learning, adaptive boosting, support vector machine and multilayer perceptron artificial neural network to predict rock saturation exponent parameter in terms of rock absolute permeability, porosity, resistivity index, true resistivity, and water saturation based on acquired 1041 field data.

Optimizing qubit performance through smoothing techniques.

This study explores an approach to enhance the performance of qubits by leveraging signal smoothing algorithms applied to qubit chips. The primary aim is to mitigate experimental variability and enhance overall stability, tied to the improvement of the Hamiltonian spectrum. By optimizing qubit operation through smoothing techniques, data processing for subsequent stages of two-tone qubit spectroscopy data transformation is facilitated.

Parasites specific to centipedes form a new major lineage of terrestrial gregarines.

Gregarines from the families Dactylophoridae and Trichorhynchidae parasitize exclusively centipedes and have a distinct morphology among other terrestrial eugregarines, but their evolutionary relationships have not yet been studied with molecular methods. Here we obtain rDNA operon sequences for the dactylophorids and trichorhynchids. We describe a new species Trichorhynchus efeykini sp.

Chemical compatibility at the interface of garnet-type Ga-LLZO solid electrolyte and high-energy Li-rich layered oxide cathode for all-solid-state batteries.

All-solid-state batteries (ASSBs) with a garnet-type solid electrolyte have been considered promising alternatives to traditional batteries with a liquid organic electrolyte, due to their enhanced safety and ability to accommodate high energy density electrodes. In this study, we conducted a comprehensive investigation of the high-temperature chemical compatibility between the garnet-like LiGaLaZrO (Ga-LLZO) electrolyte and high-energy-density Li-rich layered LiNiMnO cathode (LNM). Our findings suggest that a high temperature reaction between the Li-rich cathode and Ga-LLZO occurs at 700-900C depending on the form of reactants.

Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers.

The coordination of chromatin remodeling is essential for DNA accessibility and gene expression control. The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays a central role in cell type- and context-dependent gene expression. Despite the absence of a defined DNA recognition motif, SWI/SNF binds lineage specific enhancers genome-wide where it actively maintains open chromatin state.