'Traditional values' as a cure: The biopolitics of HIV in Putin's Russia.

This article examines the biopolitical dimensions of Russia's response to HIV within the ideological framework of 'traditional values' promoted by the Putin administration since the early 2010s. Through a discourse analysis of state-affiliated expert rhetoric and policy documents, the study elucidates how HIV has come to be framed as a moral, political, and national security threat, rather than a public health crisis. It argues that the Kremlin's turn to conservative, exclusionary frames has facilitated the externalisation of HIV as a problem resulting from the imposition of "Western" values and the "risky behaviour" these values allegedly promote.

The influence of gender on the clinical and dynamic indicators of alcohol dependence, the level of aggression of patients taking into account comorbidity with affective disorders.

To assess the influence of comorbid affective disorders (AD) on the clinical and dynamic indicators of alcohol dependence syndrome (ADS), the level of aggression in patients, and to examine gender differences. Two groups were analyzed: Group F10 ( = 149) included patients with ADS without comorbid AD, and group F10 + F3 ( = 61) of patients with ADS comorbid with AD. Clinical-psychopathological, clinical-follow-up, psychometric, and statistical methods were used.

Interfacial Structural Transformation for the Synthesis of Lead-Free Double Perovskite Nanocrystals.

Lead-free halide double perovskite nanocrystals have emerged as one of the most promising alternatives to lead halide perovskite nanocrystals due to their non-toxicity, high stability, and outstanding optoelectronic properties. However, conventional synthesis methods often result in impurities due to increased constituent elements. In this study, an efficient water-oil biphasic interface-driven approach is introduced for synthesizing lead-free double perovskite nanocrystals, enabling controlled structural transformations from 0D to 2D and 3D structures.

[Effectiveness Analysis of The I NEED HELP Scale For Prognostic Evaluation of Heart Transplant Waiting List Patients].

Aim    To evaluate the efficacy of the I NEED HELP scale in determining the six-month prognosis for patients on the heart transplant waiting list (HTWL) of the Almazov National Medical Research Center of the Russian Ministry of Health.Material and methods    This retrospective study included 42 patients from the HTWL. The patients' survival for more than 6 months was assessed.

Multifactorial Prediction of the Risk of Hospital Mortality in Patients With Acute Coronary Syndrome.

Aim      To identify predictors for the risk of in-hospital death and to develop a prognostic scale for individual risk of death in patients with acute coronary syndrome (ACS) at the hospital stage of treatment.Material and methods  A sequential retrospective analysis was conducted, including 225 patients with ACS (n=101, main group of patients who died in hospital; n=124, control group) hospitalized in the Regional Vascular Center #2 of the Semashko Nizhny Novgorod Regional Clinical Hospital from January, 2021 through July, 2022. Clinical, demographic, laboratory and instrumental characteristics of patients were studied.

SUCCOR 10 years: a decade's perspective on radical hysterectomy outcomes in cervical cancer.

Objective: Interest in long-term outcomes of radical hysterectomy for cervical cancer has increased, especially after the LACC trial findings, which showed worse outcomes for minimally invasive surgery. However, limited information is available on 10-year oncological outcomes, particularly, recurrence and survival. The primary objective of this study was to analyze the 10-year oncological outcomes of patients with International Federation of Gynecology and Obstetrics 2009 stage IB1 cervical cancer treated with radical hysterectomy performed via minimally invasive or open approaches.

Progressive evolution of plants: a critical review.

A comprehensive review of the evolutionary mechanisms in plants has been performed. This review examines fundamental questions regarding plant evolution, including the development of sexes, convergent characteristics, and neutral effects in plant ecosystems. The available evidence suggests that plant evolution is not a random process, as previously hypothesized.

Golden Gate cloning enables efficient concatemer construction for biophysical analysis of heterozygous potassium channel variants from patients with epilepsy.

Missense mutations that cause channelopathies usually occur in a heterozygous setting. Functional voltage-gated potassium channels are tetramers of pore-forming α-subunits. When a variant is co-expressed with the wild-type gene, six distinct tetramers can assemble.

Planktonic versus colony growth of Bacillus thuringiensis affects gene expression in vitro and infectivity against an insect host, Galleria mellonella.

The entomopathogenic bacterium, Bacillus thuringiensis, can complete its life cycle in environments of varying densities like insects, cadavers and soil. The stationary growth phase of the bacterial lifecycle includes virulent, necrotrophic and sporulation stages, which are under the control of pleotropic regulators of quorum sensing. In addition to insecticidal Cry-toxins, B.

Fully Percutaneous Posterior Transarticular C1-C2 Stand-Alone Screw Instrumentation: A Case Series and Technical Note.

Unlabelled: Magerl's technique remains a widely accepted method for achieving C1-C2 fusion. Although two approaches using intermuscular corridors and biplanar X-ray guidance have been reported, there are no published studies dedicated to fully percutaneous techniques employing cannulated screws.

Objective: to demonstrate the feasibility of a fully percutaneous C1-C2 fixation technique using cannulated screws and to analyze the short- and long-term outcomes of the initial case series.

Linking environmental factors to macrozooplankton size structure in summer: Insights from an Arctic shelf.

The distribution, abundance, and size structure of macrozooplankton populations in eight common taxa (Themisto libellula, Thysanoessa inermis, Limacina helicina, Aeginopsis laurentii, Aglantha digitale, Dimophyes arctica, Mertensia ovum, Parasagitta elegans) were studied in the Barents Sea in summer 2013. Four water masses were delineated based on hydrological characteristics: Murmansk Coastal Water-MCW, Atlantic Water-AW, Arctic Water-ARW, Barents Sea Water-BSW. Total abundance of macrozooplankton taxa varied between 24 and 732 individuals m.

Attenuation of viral replication foci in nuclei by 1,6 Hexanediol implicates phase separation in the assembly of baculoviral replication factories.

The assembly of replication factors into functional complexes is crucial for the initiation of viral genome replication and processing of nascent viral DNA. Binding to viral DNA and interaction of protein domains presumably guide compartmentalization of replication factors. The phase separation due to hydrophilicity and hydrophobicity of components may also contribute to the assembling process.

FeO loaded biochar to enhance persulfate activation for tetracycline degradation: Performance and mechanism.

Waste sodium lignosulfonate (LS) is widely converted into biochar-based catalysts due to its rich functional groups and high carbon content. However, inefficient peroxydisulfate (PDS) activation by original sodium lignosulfonate biochar (LB) limits its ability to remove organic pollutants from water bodies. Here, LS was employed as a precursor to synthesize FeO-loaded biochar (FeO@LB) through a one-step pyrolysis process for activating PDS to remove tetracycline (TC).

Inflammasomes in lymphocytes as therapeutic targets.

Inflammasomes are cytoplasmic macromolecular complexes playing an important role in sensing exogenous and endogenous stimuli. Inflammasome activation leads to IL-1β and IL-18 secretion and pyroptosis. The concept of non-self recognition triggering inflammasome activation has been well-established for myeloid cells.

Impact of Intermolecular Forces on Structural Changes and Local Density Fluctuations of CO in Liquid and Supercritical Phases.

This study uses molecular dynamics simulations to investigate the structural features of carbon dioxide (CO) in the liquid and supercritical phases at different isobars. Density fluctuations, which mark the liquid-to-gas-like crossover, were quantified using advanced statistical tools such as nearest-neighbor distance distributions, interaction energies, and local density profiles derived from Voronoi analysis and density-based spatial clustering of applications with noise. Our findings reveal that these fluctuations arise from the temperature-dependent difference in the spatial extent of attractive contributions from electrostatic (ES) and Lennard-Jones (LJ) potentials, leading to a maximum in the contrast between the packed and loose density domains.

Optical Quantum Memory on Macroscopic Coherence.

We propose a quantum memory based on the precreated long-lived macroscopic quantum coherence. It is shown that the proposed approach provides new physical properties and methods for retrieval of the signal light fields and improvement of the basic parameters of quantum memory. We demonstrate how the precreated coherence can enable quantum storage with low quantum noise and programmable and on demand retrieval of signal light fields in atomic ensembles with natural inhomogeneous broadening.

Topological Pumping of Multifrequency Solitons.

We report on the topological pumping of quadratic optical solitons, observed through their quantized transport in a dynamic optical potential. A distinctive feature of this system is that the two fields with different frequencies, which together form the quadratic soliton, evolve in separate yet topologically equivalent dynamic optical potentials. Pumping in this system exhibits several notable differences from pumping in cubic media.

The Source of Some Empirical Density Functionals van der Waals Forces.

Density functional approximations became indispensable tools in many fields of chemistry due to their excellent cost-to-accuracy ratio. Still, consideration is required to select an appropriate approximation for each task. Highly parameterized Minnesota functionals are known for their excellent accuracy in reproducing thermochemical properties and, in particular, weak medium-range interactions.

Biochemical properties of molybdenum cofactor isolated from fish liver.

Recent studies have demonstrated that the fish liver protein fraction extract obtained by gel filtration exhibits nitric oxide synthase (NOS)-independent NO synthase from nitrates and nitrites. This activity was attributed to the molybdenum enzymes (Mo-enzymes) group which was already demonstrated in mammals. However, the evidence that NOS-independent NO synthase activity can be classified as a fish Mo-enzyme has been poorly demonstrated.

Novel type II toxin-antitoxin systems with VapD-like proteins.

Unlabelled: Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin. The VapD nuclease and the VapX antitoxin comprise a type II TA system that contributes to the virulence of the human pathogen .

Identification of the Novel HLA-DQB1*06:02:65 Allele in a Russian Bone Marrow Donor.

The new HLA-DQB1*06:02:65 allele showed one synonymous nucleotide difference compared to the HLA-DQB1*06:02:01:01 allele in codon 591.

Description of the Novel Allele HLA-B*18:01:56 With Two Synonymous Substitutions.

HLA-B*18:01:56 showed two synonymous nucleotide differences compared to the HLA-B*18:01:01:01 allele in codons 224 and 225.

Cucurbit[7]uril-Styryl dye complexes for Fluorescent Recognition of DNA and Cell Imaging.

This paper focused on the DNA-binding properties of novel dicationic cyanine dyes, in which pyridinium centers are linked by bridges of different functionalities. We found that dye 1, bearing a flexible butyl-4-methylpyridinium terminal fragment, has the ability to bind to the DNA groove. The attachment of a quite rigid para-xylylene-4-methylpyridinium unit as a terminal group in dye 2 contributed to dual DNA-binding modes: intercalation and groove binding.

Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective.

The MAPK pathway has four main components: RAS, RAF, MEK, and ERK. Among these, RAS is the most frequently mutated protein and the leading cause of cancer. The three isoforms of the RAS gene are HRAS, NRAS, and KRAS.