Assessment of Fluid Responsiveness via Central Venous Ultrasound Measurement: A Network Meta-Analysis.

Ultrasonographic assessment of the diameters of various veins and their indices are among the most applied diagnostic tools for evaluating fluid responsiveness in clinical practice. Despite their widespread use, there is no definitive answer on which is preferable. Our study aimed to investigate the diagnostic accuracy of different venous diameters and their indices to assess fluid responsiveness.

Spatial Distribution Dynamics of Sensory Disturbances in the Treatment of Obesity-Related Meralgia Paresthetica Using Transcutaneous Electrical Nerve Stimulation.

To date, there have been no studies on the dynamics of areas of pain, paraesthesia and hypoesthesia after the use of various transcutaneous electrical nerve stimulation in the treatment of meralgia paresthetica. In this pilot study, we observed 68 patients with obesity-related bilateral meralgia paresthetica. Pain syndrome, paraesthesia symptoms, and hypoesthesia were evaluated using 10-point scores.

Dynamics of Glycemic Status and Glucose Metabolism Markers 12 Months After Coronary Artery Bypass Grafting and Their Relationship with the Annual Prognosis of Patients.

We aim to evaluate the dynamics of glycemic status and markers of carbohydrate metabolism 12 months after coronary artery bypass grafting (CABG) and their relationship with the one-year prognosis. The analysis of outcomes of 653 patients during 1 year after coronary artery bypass grafting is presented. In those patients who visited the study center after 1 year, markers of carbohydrate metabolism (glucose, glycated hemoglobin, fructosamine, 1.

6-Bromoindole- and 6-Bromoindazole-Based Inhibitors of Bacterial Cystathionine γ-Lyase Containing 3-Aminothiophene-2-Carboxylate Moiety.

In recent years, a number of synthetic potentiators of antibiotics have been discovered. Their action can significantly enhance the antibacterial effect and limit the spread of antibiotic resistance through inhibition of bacterial cystathionine-γ-lyase. To expand the known set of potentiators, we developed methods for the synthesis of five new representatives of 6-bromoindole derivatives-potential inhibitors of bacterial cystathionine-γ-lyase-namely potassium 3-amino-5-((6-bromoindolyl)methyl)thiophene-2-carboxylate () and its 6-bromoindazole analogs ( and ), along with two 6-broindazole analogs of the parent compound .

«Green-Ligand» in Metallodrugs Design-Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity.

The interaction of sodium phytate hydrate CHOP·xNa·yHO (phytNa) with Cu(OAc)·HO and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu(HO)(phen)(phyt)]·2Na·2NH·32HO (), the structure of the latter was determined by X-ray diffraction analysis. The phytate is completely deprotonated; six phosphate fragments (with atoms P1-P6) are characterized by different spatial arrangements relative to the cyclohexane ring (1a5e conformation), which determines two different types of coordination to the complexing agents-P1 and P3, P4, and P6 have monodentate, while P2 and P5 are bidentately bound to Cu cations. The molecular structure of the anion complex is stabilized by a set of strong intramolecular hydrogen bonds involving coordinated water molecules.

Fluorescence Properties of Novel Multiresonant Indolocarbazole Derivatives for Deep-Blue OLEDs from Multiscale Computer Modelling.

Multiresonant fluorophores are a novel class of organic luminophores with a narrow emission spectrum. They can yield organic light-emitting devices, e.g.

Development of Homogeneous Carboxylation of Phenolates via Kolbe-Schmitt Reaction.

In this study, the homogeneous carboxylation of potassium, sodium, and lithium phenolates in DMSO solution at 100 °C by the Kolbe-Schmitt reaction was investigated. The impact of water, phenolate concentration, and cation nature on the yield of products and reaction selectivity was demonstrated. Based on the patterns observed, it was concluded that a complex cluster mechanism governs the carboxylation reaction in the solution.

Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration.

Cancer-related deaths primarily occur due to metastasis, a process involving the migration and invasion of cancer cells. In most solid tumors, metastasis occurs through collective cell migration (CCM), guided by "cellular leaders". These leader cells generate forces through actomyosin-mediated protrusion and contractility.

Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes.

Type 1 diabetes (T1D) is related to the autoimmune destruction of β-cells, leading to their almost complete absence in patients with longstanding T1D. However, endogenous insulin secretion persists in such patients as evidenced by the measurement of plasma C-peptide. Recently, a low level of insulin has been found in non-β islet cells of patients with longstanding T1D, indicating that other islet cell types may contribute to persistent insulin secretion.

Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations.

Inorganic pyrophosphatases, or PPases, are ubiquitous enzymes whose activity is necessary for a large number of biosynthetic reactions. The catalytic function of PPases is dependent on certain conformational changes that have been previously characterized based on the comparison of the crystal structures of various complexes. The current work describes the conformational dynamics of a structural model of human mitochondrial pyrophosphatase hPPA2 using molecular dynamics simulation, all-atom principal component analysis, and coarse-grained normal mode analysis.

Brain Bioelectric Responses to Short-Term Heart Rate Variability Biofeedback Training in Indian and Russian University Students Studying in the Russian Arctic.

Heart rate variability biofeedback (HRV BF) training aids adaptation to new climatic, geographical, and social environments. Neurophysiological changes during the HRV BF in individuals from tropical regions studying in the Arctic are not well understood. The aim of this study was to research electroencephalographic (EEG) changes during a single short-term HRV BF session in Indian and Russian students studying in the Russian Arctic.

Complex Inhibitor Protection of Some Steels in Hydrochloric Acid Solutions by 1,2,4-Triazole Derivatives.

The behavior of low-carbon steels (LCSs), a high-strength steel and a nickel-chromium alloy in HCl solutions in the presence of N-containing organic substances has been studied. N-containing organic substances that comprise 1,2,4-triazole in their structure (substance I and substance II) provide comprehensive protection of various steel grades from corrosion and hydrogen absorption by the metal bulk in HCl solutions under both isobaric and isochoric conditions. All the compounds studied reduce, to varying degrees, the concentration of hydrogen adsorbed and absorbed by steel in HCl solutions.

Structural Regulation and Performance Enhancement of Carbon-Based Supercapacitors: Insights into Electrode Material Engineering.

The development of carbon-based supercapacitors is pivotal for advancing high energy and power density applications. This review provides a comprehensive analysis of structural regulation and performance enhancement strategies in carbon-based supercapacitors, focusing on electrode material engineering. Key areas explored include pore structure optimization, heteroatom doping, intrinsic defect engineering, and surface/interface modifications.

Features of the Defect Structure of LiNbO:Mg:B Crystals of Different Composition and Genesis.

We proposed and investigated a refinement of technology for obtaining Mg-doped LiNbO (LN) crystals by co-doping it with B. LN:Mg (5.0 mol%) is now the most widely used material based on bulk lithium niobate.

Deep Eutectic Solvent-Assisted Synthesis of Ni-Graphene Composite Supported on Screen-Printed Electrodes for Biogenic Amine Detection.

Deep eutectic solvents (DES) have emerged as versatile, sustainable media for the synthesis of nanomaterials due to their low toxicity, tunability, and biocompatibility. This study develops a one-step method to modify commercially available screen-printed electrodes (SPE) using laser-induced pyrolysis of DES, consisting of choline chloride and tartaric acid with dissolved nickel acetate and dispersed graphene. The electrodes were patterned using a 532 nm continuous-wave laser for the in situ formation of Ni nanoparticles decorated on graphene sheets directly on the SPE surface (Ni-G/SPE).

Efficient Corona Suppression Coatings and Their Behavior in Corrosive and Icy Environments.

High-voltage transmission lines face significant challenges due to environmental exposure, including corona discharge, ice accretion, and corrosion, which impact their durability and operational efficiency. This study investigates the performance of hydrophilic and superhydrophilic organosilane coatings applied to high-voltage wires to address these issues. Using a combination of experimental setups simulating real-world conditions, we evaluated corona discharge losses, ice adhesion, and corrosion resistance on coated and uncoated wires.

Studies of Thermal Conductivity of Graphite Foil-Based Composite Materials.

We have proposed and developed a method for measuring the thermal conductivity of highly efficient thermal conductors. The measurement method was tested on pure metals with high thermal conductivity coefficients: aluminum (99.999 wt.

Effect of Elemental Iron Containing Bauxite Residue Obtained After Electroreduction on High-Pressure Alkaline Leaching of Boehmitic Bauxite and Subsequent Thickening Rate.

The use of reduction leaching in the production of alumina from bauxite by the Bayer process in order to decrease the amount of waste (bauxite residue) by adding elemental iron or aluminum, as well as Fe salts and organic compounds in the stage of high-pressure leaching, requires the purchase of relatively expensive reagents in large quantities. The aim of this study was to investigate the possibility of the use of electrolytically reduced bauxite residue (BR) as a substitute for these reagents. Reduced BR was obtained from Al-goethite containing BR using a bulk cathode in alkaline suspension.

Comparison of Pheromone Lures and Sticky Pad Color for Capturing (Lepidoptera: Gelechiidae).

Tomato leaf miner (Meyrick) (Lepidoptera: Gelechiidae) has gained the status of major pest globally. Integrated pest management (IPM) consists of different control methods. This field study was conducted to evaluate the influence of different pheromone-based traps to attract the male population and the potential of sticky pads of four different colors in capturing the adults in the absence of pheromone lures.

Assessment of Different Conventional and Biofortified Wheat Genotypes Based on Biology and Damage Pattern of and .

The lesser grain borer, (F.) (Coleoptera: Bostrichidae) and khapra beetle, E. (Coleoptera: Dermestidae) are primary stored-grain insect pests.

Heat and Cold Shocks Decrease the Incidence of Diapause in Larvae.

Insect diapause and response to thermal stress are similar in the variety of manifestations. However, the influence of thermal shocks on the incidence of insect diapause has not been sufficiently studied. Our laboratory experiments showed that both cold (-10 °C) and heat (43 °C) shocks experienced for at least 20-30 min significantly reduced the incidence of facultative larval winter diapause in the insect egg parasitoid .

Correction: Magin et al. Impact of Non-Covalent Interactions of Chiral Linked Systems in Solution on Photoinduced Electron Transfer Efficiency. 2023, , 9296.

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Regeneration of Vascular Endothelium in Different Large Vessels.

The regeneration of endothelial cells (ECs) lining arteries, veins, and large lymphatic vessels plays an important role in vascular pathology. To understand the mechanisms of atherogenesis, it is important to determine what happens during endothelial regeneration. A comparison of these processes in the above-mentioned vessels reveals both similarities and some significant differences.

Resilience of Spontaneously Hypertensive Rats to Secondary Insults After Traumatic Brain Injury: Immediate Seizures, Survival, and Stress Response.

Traumatic brain injury (TBI) is one of the primary causes of mortality and disability, with arterial blood pressure being an important factor in the clinical management of TBI. Spontaneously hypertensive rats (SHRs), widely used as a model of essential hypertension and vascular dementia, demonstrate dysfunction of the hypothalamic-pituitary-adrenal axis, which may contribute to glucocorticoid-mediated hippocampal damage. The aim of this study was to assess acute post-TBI seizures, delayed mortality, and hippocampal pathology in SHRs and normotensive Sprague Dawley rats (SDRs).

Two-Step Cell Death Induction by the New 2-Arachidonoyl Glycerol Analog and Its Modulation by Lysophosphatidylinositol in Human Breast Cancer Cells.

2-arachnadoyl glycerol (2-AG) is one of the most common endocannabinoid molecules with anti-proliferative, cytotoxic, and pro-proliferative effects on different types of tumors. Typically, it induces cell death via cannabinoid receptor 1/2 (CB1/CB2)-linked ceramide production. In breast cancer, ceramide is counterbalanced by the sphingosine-1-phosphate, and thus the mechanisms of 2-AG influence on proliferation are poorly understood.