Overlooked and underserved: how healthcare fails men in the pursuit of equity.

Purpose Of Review: Men face distinctive health-related challenges as a result of biological, behavioral, and sociocultural factors. In addition, the modern healthcare system does not offer men equal opportunities and options to ensure sex-specific access and delivery to health services. Men's health concerns are, indeed, often not addressed or even forgotten.

Circulating microRNA as promising biomarkers in hypertrophic cardiomyopathy: can advanced cardiac magnetic resonance unlock new insights in research?

Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder associated with an increased risk of arrhythmias, heart failure, and sudden cardiac death. Current imaging and clinical markers are not fully sufficient in accurate diagnosis and patient risk stratification. Although known cardiac biomarkers in blood are used, they lack specificity for HCM and primarily stratify for death due to heart failure in overt cases.

Mobility and community at Mesolithic Lake Onega, Karelia, north-west Russia: insights from strontium isotope analysis.

Unlabelled: This study investigates the underlying mechanisms driving the formation of the largest known burial site of the Northern European Mesolithic, Yuzhniy Oleniy Ostrov (YOO). Radiogenic strontium isotope analysis (Sr/Sr) was used to identify group dynamics within the cemetery and examine the site's place within local and supra-regional networks. The analysis of 57 humans and 31 animals was supported by the creation of an environmental baseline which identified four key geological zones and defines the strontium characteristics of Lake Onega.

Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers.

Introduction: Alcoholic hallucinosis (AH) is one of the severe complications of chronic alcoholism, characterized by psychotic symptoms such as auditory hallucinations and delusions. Haloperidol is widely used to treat AH; however, its therapy is often complicated by side effects. A personalized approach using pharmacogenetic testing (particularly the CYP2D6 polymorphism) allows individualization of haloperidol dosage, improving both safety and efficacy of therapy.

The long-term effect of social, educational, and health expenditures on indicators of life expectancy: an empirical analysis for the OECD countries.

Life expectancy provides insights into population health and the socio-economic development level of a country. However, there has been a significant gap in life expectancy between developed and underdeveloped countries, although these countries and international institutions have focused on reducing these inequalities. This article explores the long-term effects of social, educational, and health expenditures together with GDP on indicators of life expectancy in the OECD states over the period of 2005-2021 through second-generation cointegration analysis.

Novel automated method to assess group dynamics reveals deficits in behavioral contagion in rats with social deficits.

Behavioral copying is a key process in group actions, but it is challenging for individuals with autism spectrum disorder (ASD). We investigated behavioral contagion, or instinctual replication of behaviors, in Krushinky-Molodkina (KM) rats ( = 16), a new potential rodent model for ASD, compared to control Wistar rats ( = 15). A randomly chosen healthy Wistar male ("demonstrator rat") was introduced to the homecage of experimental rats ("observers") 10-14 days before the experiments to become a member of the group.

Experimental and Computational NMR Studies of Large Alkaloids Exemplified With Vindoline Trimer: Advantages and Limitations.

The complete H and C NMR assignments of a trimeric vindoline together with its individual components, dimeric vindolicine and monomeric vindoline, are performed based on a thorough analysis of the ROESY, COSY, HSQC, and HMBC spectra in combination with the state-of-the-art quantum-chemical calculations. A spatial structure of vindoline trimer is determined by means of computational conformational analysis in combination with the probability distribution map of its basic conformers. On the example of monoterpene indole alkaloid, the trimer vindoline, the present study reveals the power of modern computational NMR to perform identification and stereochemical studies of large natural compounds with some limitations, which may arise in the quantum chemical computing workflow.

Features of the interaction of 5-[4'-(6″-aminopurin-2″-yl)phenyl]-10,15,20-tri(N-methylpyridin-3'-yl)-porphyrin with nucleic acids.

Directed synthesis of novel water-soluble asymmetric porphyrins containing in a molecule three cationic fragments and residues of adenine (PorAD) was performed, using metal-complex catalysis method. The interaction of the synthesized porphyrin with the oligonucleotides poly[d(AT)2] and poly[d(GC)2] and double-stranded deoxyribonucleic acid of the calf thymus (ctDNA) was studied by means of spectral and hydrodynamic methods. It was established that PorAD intercalated not only into GC-enriched regions, but also into AT regions.

[A unified digital circuit in ensuring operative monitoring of carbohydrate metabolism in middle, elderly and senile aged people in the conditions of a new coronavirus infection.].

One of the positive aspects of the implementation of laboratory information systems (LIS) in a medical organization, according to the plan of the Federal project of the Ministry of Health of the Russian Federation to create a unified digital circuit in healthcare, is the emergence of the ability to download large amounts of laboratory research data and analyze them. The purpose of the work is to assess the possibility of a unified digital circuit in providing operational monitoring of carbohydrate metabolism in middle-aged, elderly and senile people in the context of COVID-19. The materials used are the primary data of laboratory research results from the LIS «Ariadna.

[Determination of the goals of therapeutic control of type 2 diabetes mellitus in elderly patients using a digital clinical calculator.].

According to the federal register, up to 3,77 million elderly Russians have a confirmed diagnosis of type 2 diabetes mellitus (DM2), the most important criterion for the effectiveness of treatment of which is the achievement of therapeutic control targets. At the same time, the structure of the algorithm for their assessment in elderly patients is quite complex and involves the analysis of many different parameters, including indicators of geriatric status. The aim of the study was to develop a digital clinical calculator for determining individual goals of DM2 control in elderly patients based on the principles of evidence-based medicine.

[Peculiarities of the time of manifestation of a number of diseases in the periods before and after the COVID-19 pandemic according to the data of municipal polyclinics of Sakhalin region.].

The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.

[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].

The review presents the results of long-term research conducted by the staff of the Saint-Petersburg Institute of Bioregulation and Gerontology, dedicated to the study of the biological activity of peptide bioregulators at all levels of a living organism's organization. This review compares the findings of domestic and international studies in this field. At the same time, the priority of Russian scientists in the use of buccal epithelium as a diagnostic marker of age-associated pathology is indicated.

[Russian and European experience in implementing the concept of active longevity.].

The article presents an analysis of the medical, demographic and socio-economic conditions for the implementation of the active longevity policy in Russia and European countries. Based on statistical data from Rosstat, OECD Statistics, UNECE Statistical Database and Eurostat, the peculiarities of the aging of population and the non-standard age profile of wages in Russia are demonstrated. The Russian and European experience of implementing the ideas of the concept of active longevity is considered, on the basis of which the features and main trends in this area are highlighted.

Integrative review of , and (Lepidoptera, Noctuidae, Xyleninae, Apameini).

The relationship of Mikkola, 1980; Mikkola, 1998; and Mikkola, 1998 is reconsidered based on 59 genitalia slides (37 males and 22 females) and 40 barcodes of adults collected from the type localities and areas in-between. Due to lack of stable morphologic differences, apart from the wing coloration of , and low genetic distance between the three, they are considered as three subspecies of : the nominotypical one and Included are photographs of all specimens covering 37 adults, and 28 male and 18 female genitalia, as well as a phylogenetic tree and a map showing collecting localities.

Eastern filbert blight resistant identified from 20 years of germplasm introduction and evaluation at Rutgers University, New Jersey, USA.

The stem canker disease eastern filbert blight (EFB), caused by , is a major impediment of European hazelnut () production in the United States. While most European hazelnut cultivars are highly susceptible to the pathogen, which remains confined to North America, EFB resistant and tolerant genotypes occur in the gene pool at low frequency. At Rutgers University, New Brunswick, NJ, USA, 5,226 trees were grown from open pollinated seeds collected from Russia, Crimea, Poland, Turkey, Estonia, Latvia, Lithuania, Moldova, Azerbaijan, Italy, and the Republic of Georgia between 2002 to 2010.

The Rey Auditory Verbal Learning Test: adaptation into Russian and a new digital "RAVLT World".

The Rey Auditory Verbal Learning Test (RAVLT) is a classic test used to assess episodic verbal memory in research and clinical practice. We aimed to adapt the RAVLT materials into Russian, provide performance norms across the adult lifespan for the Russian adaptation, and develop a mobile application for automated RAVLT administration across languages. We created three psycholinguistically matched alternative versions of the RAVLT materials in Russian and incorporated them into a new tablet application.

An α7 nicotinic and GABA receptor-mediated pathway controls acetylcholine release in the tripartite neuromuscular junction.

Terminal Schwann cells (TSCs) are capable of regulating acetylcholine (ACh) release at the neuromuscular junction (NMJ). We have identified GABA as a gliotransmitter at mouse NMJs. When ACh activates α7 nicotinic ACh receptor (nAChRs) on TSCs, GABA is released and activates GABA receptors on the nerve terminal that subsequently reduce ACh release.

A New Empirical Equation to Take Into Account the Influence of Ionic Strength on Electrophoretic Mobility and Determination of Binding Constants of Ester Betulin Derivatives With Sulfated β-Cyclodextrin by Affinity Capillary Electrophoresis.

An empirical equation relating electrophoretic mobility and ionic strength was proposed. The equation includes a number of parameters that are found using the mobilities of reference ions: two coefficients in the numerator describing the linear relationship of the multiplier in front of the square root of the ionic strength with the product of the ion mobility in the background electrolyte (BGE) without additives by the modulus of the charge number, raised to a certain power, and also the multiplier in the denominator before the square root of the ionic strength. The proposed equation was tested using the mobilities measured in BGEs with the addition of sodium chloride to adjust ionic strength and sulfated β-cyclodextrin (S-β-CD) for 11 anions with charge numbers from -1 to -4.

Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics.

Infections caused by gram-negative pathogens continue to be a major risk to human health because of the innate antibiotic resistance endowed by their unique cell membrane architecture. Nature has developed an elegant solution to target gram-negative strains, namely by conjugating toxic antibiotic warheads to a suitable carrier to facilitate the active import of the drug to a specific target organism. Microcin C7 (McC) is a Trojan horse peptide-conjugated antibiotic that specifically targets enterobacteria by exploiting active import through oligopeptide transport systems.

Modeling the supply chain sustainability imperatives in the fashion retail industry: Implications for sustainable development.

The resilience of established business strategies has been tested in the wake of recent global supply chain upheavals triggered by events like the COVID-19 pandemic, Russia-Ukraine combat, Hamas-Israel war, and other geopolitical conflicts. Organizations are compelled to integrate sustainable practices into their supply chains to navigate the complexities of the post-COVID-19 era and mitigate the far-reaching consequences of such disruptions. However, exploring supply chain imperatives from sustainability dimensions still remains underexplored, presenting a significant research gap, particularly in the fashion retail sector.

Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single-Gene BDH1 Duplications.

Background: Chromosome 3q29 duplication syndrome is a rare chromosomal disorder with a frequency of 1:5000 in patients with a neurodevelopmental phenotype. The syndrome is characterized by phenotypic polymorphism and reduced penetrance.

Methods: Patients were investigated by performing a cytogenetic analysis of GTG-banded metaphases, aCGH with the SurePrint G3 Human CGH Microarray 8×60K, qPCR, FISH, and WES.

Ultrastructural Remodeling of Cardiomyocytes in Postinfarction Myocardium of Rats in the Late Stages of the Disease.

Identifying factors that contribute to the transition to the dilated phase in cardiac ischemia is a critical challenge in heart failure treatment. Currently, no effective therapies exist for this ischemic complication, and the mechanisms driving left ventricular dilatation during chronic post-infarction remodeling remain poorly understood. One potential pathological process leading to ventricular dilatation involves specific compensatory rearrangements in the border zone adjacent to the infarct, which isolates the intact myocardium from inflammation at the scar edge.

Coefficients in Taylor's law increase with the time scale of water clarity measurements in a global suite of lakes.

Identifying the scaling rules describing ecological patterns across time and space is a central challenge in ecology. Taylor's law of fluctuation scaling, which states that the variance of a population's size or density is proportional to a positive power of the mean size or density, has been widely observed in population dynamics and characterizes variability in multiple scientific domains. However, it is unclear if this phenomenon accurately describes ecological patterns across many orders of magnitude in time, and therefore links otherwise disparate observations.

Lacustrine sedimentation patterns at the Northern Antarctic Peninsula and surroundings as a response to late Holocene and Modern Climate changes.

The Northern Antarctic Peninsula (NAP) and the West Antarctic Ice Sheet (WAIS) are likely to respond rapidly to climate changes by increasing the collapse of peripheral ice shelves and the number of days above 0 °C. These facts make this region a representative hotspot of the global sea level rise and the location of one of the global climate tipping points (thresholds in the Earth system whose changes may become irreversible, if exceeded). Understanding the climate evolution of the NAP, based on past evidences, may help infer its future scenario.

War Anxiety: A Review.

Purpose Of Review: This review critically evaluates literature on war-induced anxiety, highlighting findings from 2021 to 2024, especially during the Russia-Ukraine war.

Recent Findings: Measures and prevalence estimates of anxiety and fear are updated. Populations affected by armed conflicts include residents of conflict zones and neighboring countries, internally displaced persons, refugees, combatants, and healthcare and humanitarian aid workers.