Draft genome sequences of strain U848 isolated from .

is a yeast widely used in the dairy industry and frequently isolated from vineyards and wineries. Its capacity to metabolize diverse sugars makes it highly promising for winemaking applications. We report the draft genome sequence of the strain U848.

Small molecule ATM inhibitors as potential cancer therapy: a patent review (2003-present).

Introduction: The ataxia telangiectasia mutated kinase (ATM) is key in coordinating the DDR signaling network essential for responding to double-strand breaks (DSBs). Several ATM inhibitors are being investigated for potential anticancer treatment in clinical trials.

Areas Covered: This review aims to provide a comprehensive overview of patents and patent applications since 2003, with a particular focus on the structural properties, activity and efficacy of the claimed ATM kinase small-molecule inhibitors.

Multidisciplinary approach in the management of simultaneous stroke and acute arterial ischemia of the arteries of the upper extremity: A case report.

This case report presents a clinical case of management of a patient with concomitant ischemic stroke and acute arterial ischemia of the right upper limb. Emergency thrombaspiration from the middle cerebral artery improved the patient's neurological status. A hybrid intervention was carried out to restore blood flow in the right upper limb: brachial artery arteriotomy with thrombectomy through an open approach combined with endovascular recanalisation and balloon angioplasty of the forearm arteries.

A multi-trait approach identified 7 novel genes for back pain.

Introduction: Back pain (BP) is a complex heritable trait with an estimated heritability of 40% to 60%. Less than half of this can be explained by known genetic variants identified in genome-wide association studies.

Objectives: We applied a powerful multi-trait and gene-based approach to association analysis of BP to identify novel genes associated with BP.

Configurational Field Analysis: a new approach to global field dynamics.

This paper advances the theory of Configurational Field Analysis (CFA) as a reconfiguration of Pierre Bourdieu's field theory, aiming to address the limitations of Global Field Theory in analyzing the complexities of global and transnational phenomena. While the concept of the Global Field extended Bourdieu's ideas to transnational and global arenas, it has been critiqued for its structural determinism, Eurocentrism, and its inability to fully capture the fluid, indeterminate, and contingent nature of global social dynamics. In response, this paper introduces social configurations as dynamic, relational constructs that emerge from specific historical and contextual conditions, rather than as fixed and universal structures.

Prospects for the development of the electronic prescription system in the conditions of the modern pharmaceutical market of Russia.

Background: This research aims to assess the level of awareness and readiness for the utilization of Electronic Prescription System (EPS) among medical professionals and patients, as well as to identify their opinions regarding the advantages and disadvantages of this system.

Methods: The study was conducted in Russia among 423 respondents, including medical professionals and patients, with an average age of 40 years.

Results: The awareness of EPS among medical professionals (20%) and patients (45.

Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.

The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population.

Love as a Commitment Device : Evidence from a Cross-Cultural Study across 90 Countries.

Given the ubiquitous nature of love, numerous theories have been proposed to explain its existence. One such theory refers to love as a commitment device, suggesting that romantic love evolved to foster commitment between partners and enhance their reproductive success. In the present study, we investigated this hypothesis using a large-scale sample of 86,310 individual responses collected across 90 countries.

Effects of nocodazole and latrunculin B on locomotion of amoeboid cells of Rhizochromulina sp. strain B44 (Heterokontophyta, Dictyochophyceae).

Rhizochromulina is a genus of unicellular dictyochophycean algae (Heterokontophyta), comprising a single species R. marina and numerous strains. Recently, we described the first arctic rhizochromuline-Rhizochromulina sp.

White matter lipidome alterations in the schizophrenia brain.

Numerous brain imaging studies have reported white matter alterations in schizophrenia, but the lipidome analysis of the corresponding tissue remains incomplete. In this study, we investigated the lipidome composition of six subcortical white matter regions corresponding to major axonal tracks in both control subjects and schizophrenia patients. All six regions exhibited a consistent pattern of quantitative lipidome alterations in schizophrenia, involving myelin-forming and mitochondria associated lipid classes.

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [F]fallypride positron emission tomography.

Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent.

Methods: Young social drinkers (age 18.

Thermodynamic Description of Oxotransfer Processes Involving Molybdenum and Tungsten Enzyme Models: DFT Calculations and Calorimetry.

The enthalpy of the oxotransfer reaction of [BuN][WO(mnt)] (where mnt is maleonitriledithiolate) with PPh in an inert atmosphere in an acetonitrile solution was determined by calorimetry. The obtained enthalpy value (-93 ± 5) kJ mol differs from the enthalpy value of the reaction carried out by us earlier under aerobic conditions by (16 ± 9) kJ mol. The obtained results indicate the participation of atmospheric oxygen in the catalytic process.

Antioxidant activity and protective effect of hydroxy derivatives of chalcones for sterlet (Acipenser ruthenus, Linnaeus, 1758) sperm.

The aim of this work is to study the effect of adding hydroxy derivatives of chalcones to the basic cryomedium on the ability of sterlet sperm to utilize superoxide and hydrogen peroxide, the intensity of lipid peroxidation of male fish germ cells, and their viability both before cryopreservation and after 3 days of freezing at liquid nitrogen temperature. The ability of phenolic derivatives of chalcones to increase the superoxide dismutase and catalase activities of sterlet sperm and to reduce the intensity of lipid peroxidation has been established. The antioxidant activity of the derivatives exceeds the effect of Trolox, which inhibits the functioning of the enzyme component of the antioxidant protection of fish sperm and promotes lipid peroxidation of fish sperm before cryopreservation.

The second phase of tumor invasion driven by immune cells: A study on doxorubicin-loaded PLG nanoparticles.

Poly(lactide-co-glycolide) (PLG) nanoparticles loaded with doxorubicin have reached phase-I clinical trials for treating advanced solid tumors. This study explores cell hitchhiking, where nanoparticles associate with blood cells and investigates the impact on pharmacokinetics and tumor migration. Previous findings highlighted the early post-injection phase dominated by nonspecific nanoparticle-cell interactions and burst release.

BINOCULAR INTERACTION IN AMBLYOPIA.

The review presents new ideas about developmental mechanisms of amblyopia, which are currently discussed in literature. Objective evidence has accumulated that amblyopia affects both monocular and binocular functions in visual processing. Given the increasing evidence of fundamental and clinical research, it is most likely that binocular dysfunction is primary, and monocular reduction is visual acuity is secondary to this disease.

A MODERN VIEW ON THE TREATMENT OF CLASS IV RECESSION ACCORDING TO MILLER.

Introduction: Interproximal attachment has received much attention in modern periodontology because it is a key diagnostic and prognostic factor. Currently, we can find many articles with results of bare root coverage, but few data and studies that describe root closure and obtaining interproximal attachment at the same time.

Objectives: The purpose of this study is to introduce a double-layer tunnel surgical technique for gingival papilla reconstruction and regeneration of the supraalveolar interproximal attachment.

PROSPECTS AND LONG-TERM RESULTS AFTER ENDODONTIC SURGERY.

Aim: to analyze the current literature data on the topic of prospects and distant results after endodontic surgery.

Material And Methods: A systematic review was conducted following the PRISMA 2020 guidelines. This review was written with the help of literature searches in the electronic databases Google Scholar and PubMed.

THE EFFECT OF INTRANASAL ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES OF AMINO ACID AND PEPTIDE NATURE ON THE MONOAMINE SYSTEMS OF THE BRAIN.

Introduction: The annual growth of psychiatric and neurodegenerative diseases requires new therapeutic strategies for delivering active pharmaceutical molecules to the brain. Non-invasive intranasal drug delivery is a promising method that allows bypassing of the blood-brain barrier and the liver de-toxification system.

Results: The review discusses the main results of experimental studies of the effect of intranasal substances of amino acid and peptide nature on the monoamine systems of the brain.

Two sides of the same coin: Weathering differences of plastic fragments in coastal environments around the globe.

Plastic debris in coastal environments usually undergoes weathering due to various environmental conditions. However, the weathering effects on exposed and shaded sides of the same plastics are underexplored. In this study, 1573 plastic fragments were collected from 15 coastal sites worldwide between December 2021 and December 2022, and weathering experiments were conducted outdoors.

Homologous recombination deficiency (HRD) diagnostics: underlying mechanisms and new perspectives.

Homologous recombination deficiency (HRD) is considered a universal and effective sign of a tumor's sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. HRD diagnostics have undergone several stages of transformations: from detection of point mutations in HR-related genes and large regions with loss of heterozygosity detected using single-nucleotide polymorphism arrays to whole-genome signatures of single-nucleotide variants, large genomic rearrangements (LGRs), and copy number alterations. All these methods have their own advantages and limitations.

Design and commissioning of the PRIOR-II "proton microscope for FAIR".

A new high energy proton radiography facility PRIOR-II (Proton Microscope for FAIR) has been designed, constructed, and successfully commissioned at the GSI Helmholtzzentrum für Schwerionenforschung (Darmstadt, Germany) pushing the technical boundaries of charged particle radiography with normal conducting magnets to the limits. The setup is foreseen to become a new and powerful user facility for carrying out fundamental science experiments in the fields of plasma and shock wave physics, material science, and medical physics. It will help address several unsolved scientific challenges, which require high-speed and precise non-invasive diagnostic methods capable of probing matter with up to 100 g/cm2 areal density.

Radiation-Induced Transformations of an Isolated CH···HCN Complex: Possible Way to Synthesis of Interstellar Benzonitrile.

The recent detection of benzonitrile (CHCN) in the interstellar medium is one of the most fascinating discoveries in astrochemistry and molecular astrophysics. However, the mechanism of its formation in interstellar ices remains unclear. Here, we report the first evidence for the direct synthesis of benzonitrile through the radiation-induced transformations of an isolated CH···HCN complex in inert rigid media at cryogenic temperature (4.

Large Language Model for Automating the Analysis of Cryoprotectants.

The rapid expansion of scientific literature necessitates developing efficient data extraction and analysis methods. This study presents an innovative approach to automating the extraction of cryoprotectant information from scientific publications using a generative pretrained transformer (GPT) model integrated with a Telegram bot interface. Our system processes and analyzes scientific articles to identify and extract relevant data on cryoprotectants and bacteria, significantly reducing the time required for researchers to gather essential information.

The association between melatonin-containing food consumption and sleep/meal timing and behavior in children with language difficulties.

The purpose of this study was to investigate the sleep characteristics, circadian rhythms, behavior, and postnatal development of children with and without language difficulties (LDs) and the association of these variables with melatonin-containing food (FMT) consumption. The study involved parents who anonymously and voluntarily provided their children's personal data and assessed LDs, bedtime, meal timing, behavioral problems, gross motor skill development, and FMT consumption. Multiple regression analysis was used to analyze the associations between study variables.