Higher vulnerability to poor circadian light hygiene in individuals with a history of COVID-19.

Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) in the same city of Tyumen, Russia.

A New Method of Intraoperative Modeling of Liver Cirrhosis in an Experiment.

A method of intraoperative modeling of liver cirrhosis in an experiment has been developed. Mature male Wistar rats underwent typical liver resection (~70% of the initial volume). After resection, intrahepatic injection of 1 ml ademetionine was performed (controls received 0.

Magnetic Resonance Imaging of Monocrotaline-Induced Pulmonary Hypertension in Rats Using Radial Scanning with Retrospective Gating.

Using magnetic resonance imaging (MRI) with radial scanning, images of intact rat lungs and rat lungs with pulmonary hypertension were obtained. The retrospective gating method was applied to construct images of rat lungs during inspiration and expiration phases. Lung volumes at both respiratory phases, relative tidal volume, and the percentage of lung lesions were calculated.

Features of Metabolism and Its Regulation in the Dynamics of Experimental Models of Metabolic Disorders.

Changes in the lipid and carbohydrate metabolism, adipokines, and growth factors during the development of metabolic disorders were studied in three mouse models: C57BL/6 (alimentary obesity), db/db (leptin-resistant obesity), and NOD (diabetes mellitus) lines. In the group of alimentary obesity, moderate fatty infiltration of the liver and hypertrophy of the adipose tissue, hyperglycemia, and increased concentrations of adiponectin, transforming growth factor β1 (TGF-β1), leptin, and cholesterol were detected. In the group of leptin-resistant obesity, multiple pathological changes in tissues, severe hyperglycemia and hyperleptinemia, hyperinsulinemia, and reduced concentrations of triglycerides, adiponectin, myostatin, and TGF-β1 were detected.

Stratification of Experimental LPS-Induced Systemic Inflammatory Response by Expression Level of Hif1a and NFkb Genes.

It was previously found that the severity of LPS-induced systemic inflammatory response (SIRS) in rats is determined by resistance to hypoxia and the level of Hif1a expression. Individual differences in the level of Hif1a and NFkb expression in the liver were studied in relation to the severity of inflammatory and immune reactions in LPS-induced SIRS in rats without previous placement in a ventilated decompression chamber. During the early periods after SIRS modeling, rats with high expression of the Hif1a and NFkb genes associated with increased expression of pro- and anti-inflammatory cytokines are identified.

Development of smart packaging halochromic films embedded with anthocyanin pigments; recent advances.

Nowadays, innovative biodegradable packaging based on pH-sensitive natural dyes is being developed. These smart systems quickly inform the food quality to the consumer and monitor fresh foods in real-time. Smart packaging protects food against ambiance risks and simultaneously sends information to users for variations and alterations in the packaging settings.

Point of No Return-What Is the Threshold of Mitochondria With Permeability Transition in Cells to Trigger Cell Death.

Programmed cell death (apoptosis) is essential part of the process of tissue regeneration that also plays role in the mechanism of pathology. The phenomenon of fast and transient permeability of mitochondrial membranes by various triggers, known as permeability transition pore (mPTP) leads to the release of proapoptotic proteins and acts as an initial step in initiation of apoptosis. However, a role for mPTP was also suggested for physiology and it is unclear if there is a threshold in number of mitochondria with mPTP which induces cell death and how this mechanism is regulated in different tissues.

Design, synthesis and antiviral evaluation of triazole-linked 7-hydroxycoumarin-monoterpene conjugates as inhibitors of RSV replication.

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in babies across the world. Irrespective of progress in the development of RSV vaccines, effective small molecule drugs are still not available on the market. Based on our previous data we designed and synthesized triazole-linked coumarin-monoterpene hybrids and showed that they are indeed effective in inhibiting the RSV replication.

Recombinant expression and characterization of the family 5 cellulase from in BL21-CodonPlus (DE3)-RIPL.

B. velezensis RB. IBE29 is a chitinolytic bacterium originally isolated from agricultural soil of Vietnam.

Response of to combination of virulent bacteriophage vB_SauM-515A1 and linezolid.

The combined use of lytic bacteriophages with antibiotics is currently being explored as a strategy to enhance the effectiveness of infectious disease therapies, including those caused by . In this study, we investigated the synergistic potential of bacteriophage vB_SauM-515A1 ( family) and the first-line antibiotic linezolid against the methicillin-resistant strain SA0413Rev. A checkerboard assay revealed a significant synergistic effect against planktonic cells (FIC = 0.

CeO -anchored β-Ni(OH) nanosheets onto nickel foam for efficient energy-saving hydrogen production an electrocatalytic glucose oxidation reaction.

Electrolytic glucose oxidation has garnered great interest in energy-saving hydrogen generation. However, high charge-transfer resistance and inefficient active centers have been recognized as the primary issues for poor electrochemical performance. In this study, for the first time, we offer a novel defect-rich CeO /β-Ni(OH) composite nanosheet-decorated Ni foam electrocatalyst (denoted as Ce@NF-GA), synthesized a unique hydrothermal approach under the co-participation of glycerol and acetic acid.

Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences?

Background: There is a lack of information on the current healthcare systems for children with kidney diseases across Europe. The aim of this study was to explore the different national approaches to the organization and delivery of pediatric nephrology services within Europe.

Methods: In 2020, the European society for Paediatric Nephrology (ESPN) conducted a cross-sectional survey to identify the existing pediatric nephrology healthcare systems in 48 European countries covering a population of more than 200 million children.

Psychometric properties of AMAS and math anxiety prevalence among Chinese and Russian schoolchildren: a comparative study.

The purpose of this study was to compare the prevalence of math anxiety in Russian and Chinese schoolchildren across genders and ages. The Abbreviated Math Anxiety Scale (AMAS) was used as a measurement tool for assessing math anxiety. The factor structure of the AMAS and item invariance between Russian and Chinese schoolchildren were also examined.

Targeted macrophage mannose receptor (CD206)-specific protein delivery via engineered extracellular vesicles.

Extracellular vesicles (EVs) show great potential for therapeutic delivery to human cells, with a focus on modulating immune responses. The most promising targets for inducing humoral and cellular immunity against a specific antigen are macrophages (Mϕs) and dendritic cells (DCs). Targeting mannose receptors (CD206), which are highly expressed on these antigen-presenting cells, to promote the presentation of specific antigens through EV-mediated uptake, is a promising strategy in clinical immunotherapy.

Investigating the effect of geopolitical risk on defense companies' stock returns.

This study examines the influence of geopolitical risk (GPR) on the stock returns of 75 global representative defense companies. Our argument is based on the premise that the Crimean Peninsula's 2014 annexation was a turning point for the defense industry. The study uses wavelet coherence and phase differences to examine daily datasets spanning from January 1, 2014 to December 31, 2023.

Fabrication of biocidal materials based on the molecular interactions of tetracycline and quercetin with hydroxyapatite via and In vitro approaches.

Synthetic hydroxyapatite (HA) materials with antibacterial and biocompatible properties have potential for biomedical applications. The application of various computational methods is highly relevant for the optimal development of modern materials. In this work, we used molecular docking to determine the binding constants of tetracycline (TET) and quercetin (QUE) with hydroxyapatite and compared them to experimental data of the adsorption of tetracycline (TET) and quercetin (QUE) on the HA surface.

More injury stoppage time in women compared to men in elite level football tournaments: Retrospective comparison of match injuries in 2018 FIFA Men's World Cup and 2019 FIFA Women's World Cup.

To identify the incidence of injury time-out due to field injuries in highest level professional football (soccer) international tournaments and to compare the features of these incidents between men's and women's football. The incidence of stoppage time due to incidents and the resulting injury characteristics of professional football players participating in the 2018 FIFA Men's World Cup (MWC) in Russia and the 2019 FIFA Women's World Cup (WWC) in France were examined retrospectively through video analysis. In the 2018 MWC, a total of 123 injury time-outs with 132 treatments occurred in 64 matches, while in the 2019 WWC, 142 incidents with 150 injured players were recorded in 52 matches.

Storage stability study of metronidazole and hydroxymetronidazole in chicken eggs by liquid chromatography tandem mass spectrometry.

Metronidazole (MNZ) is one of the most commonly used antibiotics in the food industry. High levels in food can lead to the development of antimicrobial resistance in humans, so it is important to monitor its levels in food. In the context of legal proceedings, it is frequently necessary to re-examine samples after an extended period of time.

Carbapenemase-Producing Enterobacterales from Patients Arriving from Ukraine in Poland, March 2022-February 2023.

Introduction: Despite a scarcity of data, before 2022 Ukraine was already considered a high-prevalence country for carbapenemase-producing Enterobacterales (CPE), and the situation has dramatically worsened during the full-scale war with Russia. The aim of this study was to analyse CPEs isolated in Poland from victims of war in Ukraine.

Methods: The study included 65 CPE isolates from March 2022 till February 2023, recovered in 36 Polish medical centres from 57 patients arriving from Ukraine, differing largely by age and reason for hospitalisation.

Anaeroselena agilis gen. nov., sp. nov., a Novel Sulfite- and Arsenate-Respiring Bacterium Within the Family Acetonemataceae Isolated from a Thermal Spring of North Ossetia.

A novel Gram-negative, motile, rod-shaped bacterium, designated 4137-cl, was isolated from a thermal spring of North Ossetia (Russian Federation). Strain 4137-cl grew at 30-50 °C (optimum 42 °C) with 0-3.5% NaCl (optimum 0-0.

Parabacteroides absconsus sp. nov., isolated from feces of a child with atopic dermatitis.

An obligate anaerobic, Gram-negative rod-shaped bacterial strain designated AD58 was isolated from the feces of a 3-year-old boy with atopic dermatitis. The closest species is Parabacteroides fecalis with 96.98% 16S rRNA gene identity.

Cerebral vein thrombosis: management tactics with a focus on pregnancy, the use of hormone therapy and assisted reproductive technologies.

Cerebral vein thrombosis is a rare, life-threatening condition that has now become more commonly diagnosed due to advancements in imaging techniques. Our purpose is to improve understanding of pathogenesis, diagnosis and pregnancy and IVF management in patients with a history of cerebral thrombosis. We present an overview of the modern tactics of anticoagulant therapy for cerebral thrombosis with a focus on pregnancy, the use of hormone therapy, and assisted reproductive technologies.

Novel Fluoroquinolones With Pinane Moiety: Synthesis and Antimicrobial Activity.

Here, we report a synthesis of fluoroquinolones carrying a monoterpene moiety at the C7 position of aromatic structure. The minimal inhibitory concentrations of fluoroquinolone fused with trans-3-hydroxy-cis-myrtanylamine 18 against Staphylococcus aureus (MSSA isolates) were two- to eightfold lower compared to moxifloxacin, although fourfold higher against MRSA isolates. The fluoroquinolone fused with (-)-nopylamine 16 was four- to eightfold less active on MSSA compared to moxifloxacin, while had similar activity on MRSA.

Contamination assessment and source identification of metals and metalloids in submicron road dust (PM) in Moscow Megacity.

The content of 39 metals and metalloids (MMs) in submicron road dust (PM fraction) was studied in the traffic zone, residential courtyards with parking lots, and on pedestrian roads in parks in Moscow. The geochemical profiles of PM vary slightly between different types of roads and courtyards but differ significantly from those in parks. In Moscow, compared to other cities worldwide, submicron road dust contains less As, Sb, Mo, Cr, Cd, Sn, Tl, Ca, Rb, La, Y, U, but more Cu, Zn, Co, Fe, Mn, Ti, Zr, Al, V.