Association of recurrent wheezing with sensitivity to cockroach allergen in inner-city children.

Background: There are numerous data that show a strong relationship between early exposure and sensitization to indoor allergens and the development of asthma and persistent wheezing in children. Most studies, however, have only examined the prevalence of allergy in children who have been identified as having asthma.

Objective: To assess the prevalence of positive skin test results to common inhaled allergens and possible association with wheezing in inner-city children being seen in a general pediatric clinic.

Experimental and emerging therapies for sepsis and septic shock.

The underlying principles of sepsis therapy have remained unchanged for decades. These include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source control directed at removal of the infection nidus whenever possible, and support of organ dysfunction. Despite advances in antibiotics, surgical techniques and organ support technology, the morbidity and mortality from sepsis-related diseases have remained substantially unchanged (30 - 50%).

Coronary artery disease in systemic lupus erythematosus: A review of the literature.

Context: Coronary artery occlusive disease is a common though underappreciated complication of systemic lupus erythematosus (SLE), typically a disease of young women. A case of a premenopausal patient with SLE and an acute myocardial infarction is presented, and the etiology and management of coronary artery disease in SLE reviewed.

Objectives: To review the incidence, risk factors, pathology and treatment of coronary artery disease in systemic lupus erythematosus.