A randomized, double-blind, placebo-controlled, phase IIa, clinical study on investigating the efficacy and safety of SPH3127 tablet in patients with essential hypertension.

Around 70% of patients diagnosed with hypertension exhibit increased levels of renin. SPH3127, an inventive renin inhibitor, has shown favorable tolerability and sustained pharmacodynamic inhibitory impact on plasma renin activity (PRA) during previous phase I trials. This phase II study was conducted to investigate the efficacy and safety of SPH3127 in patients with essential hypertension.

Optimized strategy for schistosomiasis elimination: results from marginal benefit modeling.

Background: Poverty contributes to the transmission of schistosomiasis via multiple pathways, with the insufficiency of appropriate interventions being a crucial factor. The aim of this article is to provide more economical and feasible intervention measures for endemic areas with varying levels of poverty.

Methods: We collected and analyzed the prevalence patterns along with the cost of control measures in 11 counties over the last 20 years in China.

[Advances in the diagnosis and treatment strategy of polymyxin resistant ].

In recent years, the detection rate of multidrug-resistant and pandrug-resistant has increased year on year, so polymyxin has received increasing attention as an antibiotic that is still sensitive to most of the multidrug-resistant strains. However, widespread use of polymyxin is likely to lead to the emergence of polymyxin-resistant . At the same time, the polymyxin hetero-resistance has made clinical prevention and treatment difficult.

[Optimized pathway to schistosomiasis elimination in China: a scrutiny using a marginal benefit approach].

Following concerted efforts for over 7 decades, great achievements have been gained in the national schistosomiasis control program of China. Currently, China is moving towards the stage of schistosomiasis elimination, when the major task is to make full use of available resources to improve schistosomiasis surveillance and response to sustainably consolidate gained schistosomiasis control achievements and prevent re-emerging schistosomiasis. There is therefore an urgent need for optimization of interventions for schistosomiasis elimination.

Ultrasound Image Texture Feature Learning-Based Breast Cancer Benign and Malignant Classification.

The use of ultrasound images to acquire breast cancer diagnosis information without invasion can reduce the physical and psychological pain of breast cancer patients and is of great significance for the diagnosis and treatment of breast cancer. There are some differences in the texture of breast cancer between benign and malignant cases. Therefore, this paper proposes an adaptive learning method based on ultrasonic image texture features to identify breast cancer.

Safety but Limited Efficacy of Ensartinib in ROS1-Positive NSCLC: A Single-Arm, Multicenter Phase 2 Study.

Introduction: Some ALK inhibitors with good inhibition of ROS1 in preclinical studies have been reported to be possibly beneficial in ROS1-positive NSCLC. In this work, we studied the efficacy and safety of ensartinib in the treatment of patients with ROS1-positive NSCLC.

Methods: The exploratory study was a phase 2, single-arm, multicenter design (NCT03608007).

Two-thumb-encircling hands technique is more advisable than 2-finger technique when lone rescuer performs cardiopulmonary resuscitation on infant manikin.

Objective: The 2010 guidelines recommend new requirements of the chest compression depth for infant. The compression technique recommendation for infant remains the 2-finger (TF) technique for lone rescuer and the 2-thumb-encircling hands technique for 2 rescuers. We hypothesized that the TF technique cannot result in an enough compression depth to meet the guideline requirements and that the 2-thumb-encircling hands technique will not affect the ventilation.