Exercise testing in patients with tricuspid regurgitation undergoing transcatheter tricuspid valve intervention.

Background: Transcatheter tricuspid valve intervention (TTVI) has shown promising results with persistent reduction of tricuspid regurgitation (TR) and improvements in functional class and quality of life (QOL).

Objectives: To analyze the impact of TTVI on maximal and submaximal exercise capacity (SEC).

Methods: Constant work-rate exercise-time (CWRET) testing reflects SEC, which is more likely to be relevant for daily life activities and provides more differentiated physiological insight into the nature of exercise intolerance.

The 2024 European Society of Cardiology Guidelines for Diagnosis and Management of Atrial Fibrillation: A Viewpoint from a Practicing Clinician's Perspective.

Atrial fibrillation (AF) is a complex disease requiring a multidomain and (usually) long-term management, thus posing a significant burden to patients with AF, practitioners, and health care system. Unlike cardiovascular conditions with a narrow referral pathway (e.g.

[Geriatric traumatological management of osteoporosis : "Let the first fracture be the last"].

In Germany more than 800,000 osteoporotic fractures occur every year, with severe medical, social and health economic consequences. Nevertheless, as in many other countries there is a large gap in care. Fractures frequently occur in older geriatric patients, who are increasingly being (or should be) treated in geriatric trauma centers.

Ablation Strategies for Repeat Procedures in Atrial Fibrillation Recurrences Despite Durable Pulmonary Vein Isolation: The Prospective Randomized ASTRO AF Multicenter Trial.

Background: Ablation strategies for patients with symptomatic atrial fibrillation and isolated pulmonary veins vary and their effects on arrhythmia recurrence remain unclear. A prospective randomized German multicenter trial sought to compare 2 ablation strategies in this patient cohort.

Methods: Patients with atrial fibrillation despite durable pulmonary vein isolation were randomly assigned at 7 centers to undergo low-voltage area ablation using 3-dimensional mapping and irrigated radiofrequency current ablation (group A) or empirical left atrial appendage isolation (LAAI) using the cryoballoon followed by staged interventional left atrial appendage closure (group B).

Embodying anticipated affect enhances proactive behavior in 5-year-old children.

Imagining anticipated affects can foster future-oriented behavior in adults. However, children often still have difficulties in vividly imagining how they will feel in a specific episode (affective episodic future thinking [EFT]). We investigated whether enacting anticipated affects helps children to imagine how they will feel and whether this enhances proactive behavior in turn.

Data-Efficient Active Learning for Thermodynamic Integration: Acidity Constants of BiVO in Water.

The protonation state of molecules and surfaces is pivotal in various disciplines, including (electro-)catalysis, geochemistry, biochemistry, and pharmaceutics. Accurately and efficiently determining acidity constants is critical yet challenging, particularly when explicitly considering the electronic structure, thermal fluctuations, anharmonic vibrations, and solvation effects. In this research, we employ thermodynamic integration accelerated by committee Neural Network potentials, training a single machine learning model that accurately describes the relevant protonated, deprotonated, and intermediate states.

Minimal motifs for habituating systems.

Habituation-a phenomenon in which a dynamical system exhibits a diminishing response to repeated stimulations that eventually recovers when the stimulus is withheld-is universally observed in living systems from animals to unicellular organisms. Despite its prevalence, generic mechanisms for this fundamental form of learning remain poorly defined. Drawing inspiration from prior work on systems that respond adaptively to step inputs, we study habituation from a nonlinear dynamics perspective.

Evaluating the halogen bonding strength of a iodoloisoxazolium(III) salt.

Diaryliodonium(III) salts have been established as powerful halogen-bond donors in recent years. Herein, a new structural motif for this compound class was developed: iodoloisoxazolium salts, bearing a cyclic five-membered iodolium core fused with an isoxazole ring. A derivative of this class was synthesized and investigated in the solid state by X-ray crystallography.

Introduction of the Trifluoropropionate Moiety into Aromatic Rings via Rhodium-Catalyzed Coupling of Arylboronic Acids with Diazoesters.

A catalytic method for the introduction of pharmaceutically meaningful fluorinated propionic acid side chains into aromatic compounds is presented. In the presence of rhodium catalyst [RhCp*Cl], various arylboronic acids are efficiently coupled with an easy-to-access diazoester reagent to give perfluorinated derivatives of phenylpropionic acids, including top-selling profen drugs. The key advantage of this approach is that the pharmacophore is introduced as a whole and is compatible with various functionalities and drug discovery.

Forced Friends: Why the Free Energy Principle Is Not the New Hamilton's Principle.

The claim that the free energy principle is somehow related to Hamilton's principle in statistical mechanics is ubiquitous throughout the subject literature. However, the exact nature of this relationship remains unclear. According to some sources, the free energy principle is merely similar to Hamilton's principle of stationary action; others claim that it is either analogous or equivalent to it, while yet another part of the literature espouses the claim that it is a version of Hamilton's principle.

Postnatal management of preterm infants with spinal muscular atrophy: experience from German newborn screening.

Background: The introduction of newborn screening (NBS) for spinal muscular atrophy (SMA) has increased the early diagnosis of 5q-associated SMA in presymptomatic and symptomatic preterm infants. National and international recommendations for treating preterms and newborns < 38 weeks of gestational age are unavailable. Our retrospective multicentre study aimed to evaluate the postnatal clinical course of preterm infants with 5q-associated SMA diagnosed since the implementation of NBS in Germany in 2021 and to summarize the German experience regarding the decision-making process for available treatment regimens for preterm infants with ≤ 3 survival of motor neuron 2 (SMN2) copies.

[Mentally ill citizens as victims of violation of physical integrity and extermination under the NS regime based on the example of a German city].

Background: Even 90 years after the National Socialist seizure of power and the beginning of the darkest chapter of German psychiatric history, examination of the medical historical past retains great relevance as an ongoing medical responsibility. The interventions in the lives of mentally ill people by the National Socialist regime are a firmly established part of medical historical research; however, little is known about how specific regions proceeded with affected citizens.

Objective: The aim of this study was therefore to identify transfer routes of the "euthanasia" transports and places of death of the victims from Bochum as well as their patient characteristics.

Structure and Dynamics of ATP and the ATP-Zn Complex in Solution.

Despite the crucial role of ATP in life and artificial life-like applications, fundamental aspects relevant to its function, such as its conformational properties and its interaction with water and ions, remain unclear. Here, by integrating linear and two-dimensional infrared spectroscopy with molecular dynamics, we provide a detailed characterization of the vibrational spectra of the phosphate groups in ATP and in its complex with Zn in water. Our study highlights the role of conformational disorder and solvation dynamics, beyond the harmonic normal-mode analysis, and reveals a complex scenario in which electronic and environmental effects tune the coupling between phosphate vibrations.

Theoretical terahertz spectroscopy of free radical solutes in solution: an EPR spin probe in water.

Free radical species are used as spin labels in electron paramagnetic resonance (EPR) spectroscopy of biomolecular systems in water, for instance in the frame of Overhauser dynamic nuclear polarization (ODNP) relaxometry to probe the local hydration water dynamics close to protein surfaces in aqueous environments. Widely used in this context are nitroxide spin probes such as TEMPO, PROXYL or MTSL derivatives. Here, we study the THz spectroscopy of HMI (2,2,3,4,5,5-HexaMethylImidazolidin-1-oxyl) in water at ambient conditions which has been recently investigated as to how its EPR properties depend on its solvation pattern in water.