Scaling up electrochemical CO reduction: enhancing the performance of metalloporphyrin complexes in zero-gap electrolyzers.

Metalloporphyrins are widely studied in the field of electrochemical CO reduction (COR), with the main focus on homogenous catalysis. Herein, six metalloporphyrins (M = Fe, Co, Ni, Cu, Zn, Ag) were incorporated in gas diffusion electrodes and used in zero-gap electrolyzers to reach varying FEs for CO of <1% (Fe,Ni), 11% (Cu), 37% (Zn), 75% (Co) and nearly 100% (Ag) at a current density of 50 mA cm.

Effects of sodium-glucose co-transporter inhibitors on individual clinical endpoints and quality of life.

Aims: Sodium-glucose co-transporter inhibitors (SGLTis) have cardiovascular protective effects. We aimed to assess the effects of SGLTis on individual hard clinical endpoints and quality of life (QoL) in patients with cardiovascular risk factors.

Methods And Results: Data was searched in PubMed, Embase, Cochrane Library and clinicaltrials.

RWI-GEO-VOTE: Small-scale data of the 2017 German federal election.

The RWI-GEO-VOTE dataset was collected to understand how the refugee inflows affected the vote share of parties in the 2017 German federal election. The dataset provides granular insights into the 2017 German federal election at the 1 km x 1 km grid cell level. Compiled by the Research Data Center (FDZ) Ruhr at RWI, it covers 175,758 grid cells and provides data on valid votes for all parties that could be elected.

The effect of positive mental imagery versus positive verbal thoughts on anhedonia.

Anhedonia, the loss of interest in and pleasure from previously enjoyable activities is a core symptom of depression and presents a major challenge to treatments. Interventions involving positive mental imagery generation have been suggested to reduce anhedonia. However, it is not clear whether the imagery component of such interventions is crucial for these effects.

[Ethical challenges of telepsychiatry].

Telepsychiatry is shifting the focus of psychiatry and psychotherapy from personal interaction and relationship building to communication with technological mediators in the form of telecommunication, virtual reality (VR), social robots or artificial intelligence (AI). This article discusses the opportunities and risks of new technologies in psychiatric treatment, taking into account the principles of medical ethics. Telepsychiatric treatments can promote self-determination in the home environment as opposed to institutionalisation but carry the risk of uncontrolled data sharing.

Stacking Fault Segregation Imaging With Analytical Field Ion Microscopy.

Stacking faults (SFs) are important structural defects that play an essential role in the deformation of engineering alloys. However, direct observation of SFs at the atomic scale can be challenging. Here, we use the analytical field ion microscopy, including density functional theory-informed contrast estimation, to image local elemental segregation at SFs in a creep-deformed solid-solution single-crystal alloy of Ni-2 at% W.

[Measurement of disease-related knowledge of patients with axial spondyloarthritis-Development and application of the G-ASKQ7 questionnaire].

Background And Objective: Patient education is an integral component of the treatment of axial spondyloarthritis (axSpA). However, the validated tools currently available for assessing disease-related knowledge are outdated and, in the case of axSpA, only available in English. The aims of this work were therefore (1) to develop a German-language tool for assessing disease-specific knowledge among axSpA patients and (2) to assess this tool in a pilot study.

Preventive catheter ablation for ventricular arrhythmias in patients with end-stage heart failure referred for heart transplantation evaluation: Rationale for and design of the CASTLE-VT trial.

Aims: Timely referrals for transplantation and left ventricular assist device (LVAD) play a key role in favourable outcomes in patients with advanced heart failure (HF). Cardiovascular mortality, driven by sudden cardiac death, is the main reason for dying while waiting for heart transplantation (HTx). The purpose of the Preventive Catheter Ablation for ventricular arrhythmiaS in patients with end-sTage heart faiLure rEferred for heart transplantation eValuaTion (CASTLE-VT) trial is to test the hypothesis that prophylactic catheter ablation of arrhythmogenic ventricular scar tissue will reduce mortality, need for LVAD implantation, and urgent HTx in patients with end-stage HF related to ischaemic cardiomyopathy (ICM).

Impact of right ventricular function on cardiopulmonary exercise capacity in mitral regurgitation patients undergoing transcatheter mitral valve intervention.

Objective: Transcatheter mitral valve interventions (TMVI) have been proven to reduce symptom burden and improve outcomes in patients with severe mitral regurgitation (MR). However, the impact of right ventricular function (RVF) on exercise capacity in MR patients is less well understood.

Methods: Cardiopulmonary exercise testing (CPET) is the most comprehensive approach to assess maximum exercise capacity.

[Health services research in acute pain medicine : Where do we come from in Germany?].

Background: Up to the early 2000s the need for optimization in the treatment of acute pain in hospitals was highlighted. Only a few successes were achieved in the optimization process. As the acute pain care in Germany remained persistently unsatisfactory, the first health services research projects in pain medicine were initiated.

Impact of symptomatic multiple sclerosis therapy on pregnancy outcome.

Background: Information on symptomatic therapy (ST) use in women of childbearing age with multiple sclerosis is sparse, and data on the impact of ST pregnancy exposure on pregnancy outcome are lacking.

Objective: To investigate (1) ST use patterns pre-conception, during pregnancy and postpartum and (2) pregnancy outcomes.

Methods: Pregnancy data from the German Multiple Sclerosis and Pregnancy Registry were analyzed for the ST use from pre-conception to postpartum.

A single-photon emitter coupled to a phononic-crystal resonator in the resolved-sideband regime.

A promising route towards the deterministic creation and annihilation of single-phonons is to couple a single-photon emitter to a mechanical resonator. The challenge lies in reaching the resolved-sideband regime with a large coupling rate and a high mechanical quality factor. We achieve this by coupling self-assembled InAs quantum dots to a small mode-volume phononic-crystal resonator with mechanical frequency Ω/2π = 1.

Synapses learn to utilize stochastic pre-synaptic release for the prediction of postsynaptic dynamics.

Synapses in the brain are highly noisy, which leads to a large trial-by-trial variability. Given how costly synapses are in terms of energy consumption these high levels of noise are surprising. Here we propose that synapses use noise to represent uncertainties about the somatic activity of the postsynaptic neuron.

The influence of robot appearance on visual perspective taking: Testing the boundaries of the mere-appearance hypothesis.

Visual perspective taking (VPT) is an integral part of social interactions. While the mechanisms of VPT have been extensively explored in human-human interactions, only a handful of studies have investigated the mechanisms that enable humans to also take the perspective of robots. Previous work has proposed that human-like visual features trigger VPT (mere-appearance hypothesis).

Nitro-fatty acids: promising agents for the development of new cancer therapeutics.

Nitro-fatty acids (NO-FAs) are endogenous pleiotropic lipid mediators regarded as promising drug candidates for treating inflammatory and fibrotic diseases. Over the past two decades, the anti-inflammatory and cytoprotective actions of NO-FAs and several molecular targets have been identified. More recently, preclinical studies have demonstrated their potential as prospective cancer therapeutics with favorable safety and tumor-selective profiles.

Regional mechanical dyssynchrony and shortened systole are present in people with Takotsubo syndrome.

Background: Takotsubo syndrome is characterized by transient regional systolic dysfunction, left ventricular (LV) dilatation, and edema, often occurring without obstructive coronary artery disease. The mechanisms underlying this stress-induced condition, especially the role of mechanical dyssynchrony in affecting systolic function, remain poorly understood.

Methods: In our study, we evaluated global LV function and mechanical dyssynchrony in 24 Takotsubo patients compared to 20 controls by analyzing pressure-volume loops and time-varying elastance.

Evidence for a general cognitive structure in pigeons (Columba livia).

A well replicated result in humans is that performance, whether good or bad, is consistent across a wide variety of cognitive tasks. Factor analysis extracts one factor that can account for approximately half of the variance in performance. This factor is termed g and almost all cognitive tasks positively load onto this factor.

Favorable outcome after fetal swallowing of a Somatex® intrauterine shunt.

This report describes the ingestion of a dislodged Somatex Intrauterine Stent by the fetus. At 35 weeks one shunt was visualized in the fetal stomach, suggesting that the fetus had swallowed it. The shunt kept its position in the stomach until the last follow up scan at 37 weeks.

Parity and time-reversal violating nuclear forces with explicit -excitations.

We emphasize the usefulness of treating delta resonances as explicit degrees of freedom in applications of chiral effective field theory (EFT) to parity-violating and time-reversal-violating (PVTV) nuclear interactions. Compared with the delta-less framework, the explicit inclusion of the delta isobar allows one to resum certain types of contributions to the PVTV two-pion exchange two- and three-nucleon potentials without at the same time introducing any unknown parameters up to next-to-next-to-leading order in the EFT expansion. We provide the corresponding expressions for the delta contributions in momentum and coordinate spaces and compare the convergence of the EFT expansion in both formulations.