1 results match your criteria: "Royal Victoria Hospital and Research Institute of McGill University Health Centre[Affiliation]"
Impact of assisted reproduction, infertility, sex and paternal factors on the placental DNA methylome.
Hum Mol Genet
February 2019
MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Royal Victoria Hospital and Research Institute of McGill University Health Centre, Quebec, Canada.
Article Synopsis
- Children conceived using Assisted Reproductive Technologies (ART) tend to show higher rates of growth and birth defects, which may be linked to epigenetic changes caused by ART and parental infertility.
- Mouse studies indicate that the placenta is particularly vulnerable to these epigenetic abnormalities, making it a valuable indicator for identifying 'at risk' pregnancies.
- In a study analyzing placental epigenetics in ART and control groups, distinct patterns were observed in ART pregnancies, especially those from IVF/ICSI methods, revealing how both infertility and specific ART techniques can impact the placental epigenome.