functions as a potential novel oncopromoter in colorectal cancer: a comprehensive analysis of the gene family.

Pre-B-cell leukaemia (PBX) is a transcription factor family ( and ) that regulates important cellular functions and has been identified to be involved in human cancers. This study aimed to explore the expression of genes and their clinical significance in colorectal cancer (CRC). We analysed the differential expression of genes in CRC vs.

COVID-19 recognition and digital risk stratification.

In the acute hospital setting the COVID-19 pandemic presents some unique challenges to acute patient care. These include accurate recognition of cases, confirmation of both testing requests and results, establishing patient acuity and alerting to deterioration. We report our experience introducing a digital COVID-19 assessment tool with an associated live dashboard at two acute NHS hospitals, enabling accurate hospital-level reporting alongside risk stratification.

Effectiveness of a quality improvement collaborative in reducing time to surgery for patients requiring emergency cholecystectomy.

Background: Acute gallstone disease is a high-volume emergency general surgery presentation with wide variations in the quality of care provided across the UK. This controlled cohort evaluation assessed whether participation in a quality improvement collaborative approach reduced time to surgery for patients with acute gallstone disease to fewer than 8 days from presentation, in line with national guidance.

Methods: Patients admitted to hospital with acute biliary conditions in England and Wales between 1 April 2014 and 31 December 2017 were identified from Hospital Episode Statistics data.

Cost-effectiveness of a quality improvement bundle for emergency laparotomy.

Background: The recent Emergency Laparotomy Pathway Quality Improvement Care (ELPQuiC) study showed that the use of a specific care bundle reduced mortality in patients undergoing emergency laparotomy. However, the costs of implementation of the ELPQuiC bundle remain unknown. The aim of this study was to assess the in-hospital and societal costs of implementing the ELPQuiC bundle.

Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans.

Objective: Unlike gastric banding or sleeve gastrectomy procedures, intestinal bypass procedures, Roux-en-Y gastric bypass in particular, lead to rapid improvements in glycaemia early after surgery. The bypass of the proximal small bowel may have weight loss and even caloric restriction-independent glucose-lowering properties on hepatic insulin sensitivity. In this first human mechanistic study, we examined this hypothesis by investigating the early effects of the duodeno-jejunal bypass liner (DJBL; GI Dynamics, USA) on the hepatic insulin sensitivity by using the gold standard euglycaemic hyperinsulinaemic clamp methodology.

Inadequate Preoperative Team Briefings Lead to More Intraoperative Adverse Events.

Introduction: Implementation of the World Health Organization checklists has reduced major surgical complications and errors; however, the impact of preoperative briefings on intraoperative adverse events has not been assessed.

Materials And Methods: A prospective case-control study assessing the association between preoperative briefings and minor, potentially major, and major adverse intraoperative events was performed in 2 phases. Phase 1 involved prospective data collection for all trauma and orthopedic lists during a 2-week period.

Non coding RNAs in aortic aneurysmal disease.

An aneurysm is a local dilatation of a vessel wall which is >50% its original diameter. Within the spectrum of cardiovascular diseases, aortic aneurysms are among the most challenging to treat. Most patients present acutely after aneurysm rupture or dissection from a previous asymptomatic condition and are managed by open surgical or endovascular repair.

Rothia prosthetic knee joint infection: report and mini-review.

Rothia spp. are gram-positive pleomorphic bacteria that are part of the normal oral microflora. They are associated with dental and periodontal disease, although systemic infections have also been reported.

Be a true listener, rather than a good conversationalist.

Oncology patient care is an ever evolving field both as a science and a clinical art. We evaluate, diagnose, and treat cancer patients daily. We break the bad and the good news to them.

Gall bladder malignancy: an unusual association.

Gall bladder malignancy predominantly comprises adenocarcinoma and is found mostly in a late stage whereas primary lymphoma of mucosa associated lymphoid tissue (MALT) within the gall bladder is exceedingly rare and has an incidental presentation. We report a case of well differentiated adenocarcinoma with MALT lymphoma of the gall bladder in an 83 year old woman. To our knowledge, this is the first case of a carcinoma and lymphoma occurring simultaneously in the gall bladder.

Current concepts in the management of hip pain in the young adult.

Until recently, surgical management of hip disorders in adults has focused mainly on conventional total hip replacements for advanced arthritis. These have been performed mainly in the elderly, and there have been few surgical options in the younger patient. Over the past decade, the treatment of hip disorders in patients less than 55 years of age has changed rapidly; improved diagnostic techniques as well as newer diagnoses have lead to increased surgical options.

Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma.

Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph nodes (SLN) draining regressing melanomas, we found that the accumulation of mature DC-LAMP(+) DCs in SLNs was associated with local expansion of antigen-specific memory effector CTLs and the absence of metastasis in downstream lymph nodes. The aim of this study was to investigate the prognostic importance of the maximal density of mature DCs in SLNs.

Experimental Design: A total of 458 consecutive patients with micrometastatic melanoma within SLNs were eligible for analysis.

Endoluminal radiofrequency ablation of the long saphenous vein (VNUS closure) -- a minimally invasive management of varicose veins.

This report describes our clinical experience with the VNUS closure. This is a percutaneous catheter-based procedure in which the vein is ablated from within by resistive heating. We performed the UK's first radiofrequency closure without a high tie in March 1999.