2,232 results match your criteria: "Royal Liverpool Children's Hospital;[Affiliation]"
Impact of intraoperative MRI on pediatric epilepsy surgery for focal cortical dysplasia.
J Clin Neurosci
January 2025
Department of Neurosurgery, Alder Hey Children's NHS Foundation Trust, Eaton Road, L12 2AP, Liverpool, the United Kingdom of Great Britain and Northern Ireland. Electronic address:
Background: Complete resection is essential for achieving seizure freedom in children with drug-resistant epilepsy due to focal cortical dysplasia (FCD). However, identifying altered structures intraoperatively can be challenging, potentially leading to reoperations. This study assessed the impact of intraoperative MRI (iMRI).
View Article and Find Full Text PDFMolecular diagnoses and candidate gene identification in the congenital heart disease cohorts of the 100,000 genomes project.
Eur J Hum Genet
November 2024
Leeds Institute of Medical Research, University of Leeds, St James University Hospital, Beckett Street, Leeds, UK.
Congenital heart disease (CHD) describes a structural cardiac defect present from birth. A cohort of participants recruited to the 100,000 Genomes Project (100 kGP) with syndromic CHD (286 probands) and familial CHD (262 probands) were identified. "Tiering" following genome sequencing data analysis prioritised variants in gene panels linked to participant phenotype.
View Article and Find Full Text PDFManagement of Ganglioneuroma and Ganglioneuroblastoma Intermixed: A United Kingdom Children's Cancer and Leukaemia Group (UK CCLG) Nationwide Study Report.
Pediatr Blood Cancer
February 2025
Department of Paediatric Surgery, The Great North Children's Hospital, Newcastle Upon Tyne, UK.
Background: Ganglioneuroblastoma intermixed (GNBi) and ganglioneuroma (GN) represent benign variants of peripheral neuroblastic tumours. While historically surgical resection was recommended, watchful active observation has become the accepted management for a subset of patients.
Objectives: To review clinical features, biology, natural history and management of a retrospective UK CCLG study cohort of GN and GNBi, and compare outcomes of patients treated with surgical resection or watchful active observation.
Article Synopsis
- In a study on children with Phenylketonuria (PKU), casein glycomacropeptide (GMP) was compared to phenylalanine-free amino acids (AA) as a protein substitute, focusing on digestion and overall health effects.
- Results showed that GMP significantly improved gastrointestinal symptoms like stomach pain and bloating, although it did not have a major impact on other health markers like renal function or oxidative stress.
- However, GMP's higher phenylalanine content poses challenges for use as a sole protein source in PKU kids due to their low tolerance for phenylalanine.
Global burden of disease attributable to metabolic risk factors in adolescents and young adults aged 15-39, 1990-2021.
Clin Nutr
December 2024
MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address:
Background: Metabolic risk factors are a significant cause of global burden among adolescents and young adults, but there is a lack of attention to the burden attributable to these metabolic risk factors globally.
Aims: This study aims to provide comprehensive estimates of five important metabolic risk factors and the attributable disease burden in people aged 15-39 years from 1990 to 2021, based on the Global Burden of Disease Study (GBD) database.
Methods: Global total deaths and disability-adjusted life years (DALYs) were used to describe the burden attributable to five common metabolic risk factors, including high fasting plasma glucose (FPG), high low-density lipoprotein cholesterol (LDL-C), high systolic blood pressure (SBP), high body mass index (BMI), and kidney dysfunction, in adolescents and young adults.
Continuous Glucose Monitoring-Derived Glycemic Phenotyping of Childhood Hypoglycemia due to Hyperinsulinism: A Year-long Prospective Nationwide Observational Study.
J Diabetes Sci Technol
November 2024
Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK.
Article Synopsis
- The study investigates the glycemic patterns in children with congenital hyperinsulinism (HI) using Continuous Glucose Monitoring (CGM) over a 12-month period to provide better insights for future treatments.
- It involved 45 patients, revealing a consistent risk of hypoglycemia, especially early in the morning, but showed that CGM did not effectively reduce these episodes and the device's accuracy was found to be poor.
- Despite high dissatisfaction among patients and families regarding CGM usage, qualitative feedback indicated that it helped them understand glycemic patterns and make behavior adjustments to reduce hypoglycemia.
Variations in antenatal management and outcomes in haemolytic disease of the fetus and newborn: an international, retrospective, observational cohort study.
Lancet Haematol
December 2024
Division of Foetal Medicine, Department of Obstetrics, Leiden University Medical Centre, Leiden, Netherlands. Electronic address:
Background: Advances in haemolytic disease of the fetus and newborn have led to numerous treatment options. We report practice variations in the management and outcomes of haemolytic disease of the fetus and newborn in at-risk pregnancies.
Methods: In this international, retrospective, observational cohort study, data from cases with moderate or severe haemolytic disease of the fetus and newborn were retrieved from 31 centres in 22 countries.
"I'm quite proud of how we've handled it": health professionals' experiences of returning additional findings from the 100,000 genomes project.
Eur J Hum Genet
November 2024
NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Participants in the 100,000 Genomes Project (100kGP) could consent to receive additional finding (AF) results, individual variants relating to genes associated with susceptibility to cancer and familial hypercholesterolemia (FH). In the study reported here, qualitative interviews were used to explore the experiences of National Health Service (NHS) professionals from across England who were tasked with returning over 80,000 "no AF" results and 700 positive AF results to 100kGP participants. Interviews were conducted with 45 professionals from a range of backgrounds, including Genetic Counsellors, Clinical Geneticists, FH Clinical Nurse Specialists and Clinical Scientists.
View Article and Find Full Text PDFTiming of Stoma Closure in Neonates: the ToSCiN mixed-methods study.
Health Technol Assess
October 2024
National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Background: Neonates undergoing emergency abdominal surgery frequently require a stoma; closing this stoma with a second operation is an essential part of recovery. Timing of closure varies. Optimal timing is unclear and would be best resolved through a randomised controlled trial; such a trial is likely to be challenging.
View Article and Find Full Text PDFOne-year employment outcome prediction after traumatic brain injury: A CENTER-TBI study.
Disabil Health J
October 2024
Department of Public Health, Vrije Universiteit Brussel, Belgium.
Article Synopsis
- - This study explores how machine learning can predict whether individuals with traumatic brain injury (TBI) will return to work one year after their injury, using data collected from 586 hospitalized patients across Europe.
- - By analyzing hospital stay and follow-up data, the researchers found that including follow-up information significantly improved prediction accuracy, going from around 81% to 88%.
- - The final model, which included five key predictors, achieved 90% accuracy and can help clinicians set realistic goals and tailor interventions for TBI patients, enhancing their chances of returning to work.
Background: Children and young people living with severe obesity experience a range of complications of excess weight (CEW); however the prevalence of complications is not well defined. We have evaluated baseline characteristics and CEW of patients from two UK tier 3 paediatric weight management services.
Methods: All new patients aged 2-17 years seen from March 2022 to February 2023 were included.
Contributors to Organ Damage in Childhood Lupus: Corticosteroid Use and Disease Activity.
Rheumatology (Oxford)
October 2024
Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Background: Awareness of paediatric-specific predictors of damage in Childhood-lupus is needed to inform mitigation measures.
Objectives: To ascertain how clinical and demographic variables correlate with damage accrual and identify predictors of damage.
Methods: Analysis included UK JSLE Cohort Study participants.
Current Practice, Safety and Efficacy of Interventions for Recurrent Respiratory Papillomatosis: Evidence From a UK Registry.
Clin Otolaryngol
October 2024
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Article Synopsis
- - The study aimed to evaluate the safety and effectiveness of treatments for recurrent respiratory papillomatosis (RRP) in UK NHS hospitals, involving data collection from patients between April 2018 and August 2022, along with some retrospective data from earlier years.
- - A total of 304 patients (including 65 children) were analyzed; findings showed that children had a more severe form of RRP compared to adults, with microdebrider surgeries being the most common treatment.
- - The research concluded that RRP is more aggressive in children, treatment varies by age, and overall management was safe, with few complications and effective results; it highlighted the need for standardized reporting to better track disease progression and safety. *
Exploring the burden of paediatric acute otitis media with discharge in the UK: a qualitative study.
BMJ Paediatr Open
October 2024
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, UK.
Background: Acute otitis media with discharge (AOMd) results from a tympanic membrane perforation secondary to a middle ear infection. Currently, the impact of AOMd on children and young people (CYP) and their families is not well understood. There is also a need to explore the experience of healthcare professionals in treating AOMd.
View Article and Find Full Text PDFCohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study.
Int J Epidemiol
February 2024
The Institute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.
COVID-19 vaccine effectiveness and uptake in a national cohort of English children and young people with life-limiting neurodisability.
Arch Dis Child
October 2024
Population, Policy & Practice Research Programme, UCL GOS Institute of Child Health, London, UK
Article Synopsis
- The study aimed to explore the vaccination rates and effectiveness of SARS-CoV-2 vaccines in children and young people (CYP) with life-limiting neurodisabilities using national hospital data from England between December 2020 and September 2022.
- Out of 38,067 CYP identified, only 35% received at least one vaccine dose, with higher uptake in older, white children from less deprived areas; upon follow-up, vaccination did not significantly lower hospitalization rates after COVID-19 infection.
- The vaccine showed significant protection against COVID-19 hospitalizations specifically during the Alpha-Delta variant phase, but had no impact during the Omicron variant phase, highlighting low vaccine uptake and disparities in vaccination by ethnicity and socio
Closed-Loop Therapy and Sleep in Young People Newly Diagnosed With T1D and Their Parents.
J Diabetes Sci Technol
October 2024
Department of Psychology, Royal Holloway, University of London, Egham, UK.
Background: A diagnosis of type 1 diabetes in a young person can create vulnerability for sleep. Historically it has been rare for young people to be offered a closed-loop system soon after diagnosis meaning that studies examining sleep under these circumstances in comparison with standard treatment have not been possible. In this study, we examine sleep in young people (and their parents) who were provided with hybrid closed-loop therapy at diagnosis of type 1 diabetes versus those who receive standard treatment over a 2-year period.
View Article and Find Full Text PDFUpdate to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study".
Wellcome Open Res
October 2024
Paediatric Emergency Medicine Leicester Academic (PEMLA) Group, Leicester Royal Infirmary, Leicester, UK.
Background: In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.
Study Question: We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.
Non-orthogonal spectacle correction for irregular astigmatism.
Ophthalmic Physiol Opt
January 2025
Department of Materials, Design and Manufacturing Engineering, School of Engineering, University of Liverpool, Liverpool, UK.
Article Synopsis
- The study aimed to examine whether using non-orthogonal correction (NOC) lenses could enhance visual acuity and perceived image quality for patients with keratoconus.
- Researchers tested 18 participants and their 23 eyes opted for NOC lenses, finding that 61% of eyes showed improved best-corrected visual acuity (BCVA), and many reported better letter clarity and less ghosting.
- The findings suggest that NOC lenses can be an effective option for correcting irregular astigmatism in keratoconus patients, with strong interest from participants for potential future use in spectacles.
Mental Health Problems Among Indonesian Adolescents: Findings of a Cross-Sectional Study Utilizing Validated Scales and Innovative Sampling Methods.
J Adolesc Health
December 2024
Burnet Institute, Melbourne, Australia; Centre for Adolescent Health, Royal Children's Hospital, Melbourne, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia. Electronic address:
Article Synopsis
- - The study investigates the prevalence of mental health issues among adolescents aged 16-18 in Indonesia, focusing on both school-going and out-of-school teens from urban Jakarta and rural South Sulawesi.
- - Findings reveal high rates of psychological distress (24.3% in-school, 23.7% out-of-school) and depression (12.6% in-school, 23.5% out-of-school), with significant gender differences in reported conditions.
- - The research highlights the need for improved healthcare access for adolescents, especially those who are aware of their mental health issues but do not seek help, indicating a critical area for intervention.
Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma.
Cancer Res Commun
November 2024
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia.
Article Synopsis
- Further research on identified regions could enhance our understanding of genetic risks for glioma.
- The study indicates that sex might influence genetic susceptibility to glioma.
- It emphasizes the need for future glioma studies to consider sex-specific factors in their analyses.*
Pediatric MOG-Ab-Associated Encephalitis: Supporting Early Recognition and Treatment.
Neurol Neuroimmunol Neuroinflamm
December 2024
From the Department of Neurology (N.N.K., O.A.-M., Y.H.), Great Ormond Street Hospital for Children NHS Foundation Trust; Department of Neuroinflammation (N.N.K., D.C., O.A.-M., C.H., O.C., Y.H.), Institute of Neurology, University College London; Children's Neurosciences (M.E., V.L., M.L., T.R.), Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust; Department of Women and Children's Health (M.E., M.L., T.R.), School of Life Course Sciences (SoLCS), King's College London; Department of Paediatrics (A.S., S.R., J.P.), Children's Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust; Department of Paediatric Neurology (M.V.C.), Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust; Translational and Clinical Research Sir James Spence Institute (R.F.), University of Newcastle, Royal Victoria Infirmary; Department of Neurology (R.F.), Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust; Department of Neurology (R.K.), Alder Hey Children's Hospital, Alder Hey Children's NHS Foundation Trust, Liverpool; Department of Paediatric Neurology (D.R., Siobhan West), Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust; Department of Neurology (E.W., Sukhvir Wright), Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust; Department of Neuroradiology (A.B., K.M.), Great Ormond Street Hospital, Great Ormond Street Hospital Trust, London, United Kingdom; Department of Neurology (E.P.F.), Laboratory Medicine and Pathology and Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN; NIHR University College London Hospitals Biomedical Research Centre (O.C.); and Department of Neuroinflammation (O.C.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Article Synopsis
- A study assessed children under 18 with antibodies to myelin oligodendrocyte glycoprotein (MOG-Ab), focusing on those with encephalitis who didn’t fit the criteria for acute disseminated encephalitis (ADEM), comparing them to those with ADEM.
- Out of 235 MOG-Ab positive patients, 33 had encephalitis and 74 had ADEM, with common symptoms including headache, seizures, and fever; 24% had a normal initial brain MRI.
- Findings indicated that children with encephalitis were generally older, more often admitted to intensive care, and had a delayed start of steroid treatment, suggesting MOG-Ab testing is essential for suspected encephalitis
National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach.
Arch Dis Child
December 2024
Bristol Renal Unit, Bristol Royal Hospital for Children, Bristol, UK.
Article Synopsis
- IgA vasculitis (IgAV) is a common type of blood vessel disease in kids, and while most get better, some can have long-term kidney problems.
- A group of 28 experts worked for over a year to create guidelines on how to treat IgAV and its complications by reviewing many studies and getting feedback from others.
- The new guidelines have been approved by important health organizations and aim to help doctors provide better care for kids with this condition.
A multicentre observational study of paediatric head and neck abscesses.
Int J Pediatr Otorhinolaryngol
November 2024
Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, UK.
Article Synopsis
- Pediatric ENT surgeons in the UK noticed an unusual increase in severe head and neck abscesses during the winter of 2022/3, prompting a study to validate this trend and explore associated factors.
- A multicentre study collected data from 262 patients admitted with head and neck abscesses between September 2022 and February 2023, revealing a significant rise in group A streptococcus cases and complications like venous thrombosis during the winter months.
- Despite the observed increases in certain complications, the overall number of abscess cases fell within expected historical ranges, indicating that the winter 2022/2023 rates were consistent with pre-COVID trends in pediatric cases.