2 results match your criteria: "Royal Brisbane Hospital Research Foundation Clinical Research Center[Affiliation]"
Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.
Gut
January 2005
Conjoint Gastroenterology, Laboratory, Royal Brisbane Hospital Research Foundation Clinical Research Center, Brisbane, Australia.
Background: Colorectal cancers (CRCs) may be categorised according to the degree of microsatellite instability (MSI) exhibited, as MSI-high (MSI-H), MSI-low (MSI-L), or microsatellite stable (MSS). MSI-H status confers a survival advantage to patients with sporadic CRC.
Aims: To determine if low levels of MSI are related to the clinicopathological features and prognosis of sporadic stage C CRC.
Hyperplastic polyposis: association with colorectal cancer.
Am J Surg Pathol
February 2001
Conjoint Gastroenterology Research Laboratory, Royal Brisbane Hospital Research Foundation Clinical Research Center, Australia.
Article Synopsis
- Hyperplastic polyposis is linked to a significant risk of colorectal cancer, with findings from a study of twelve patients showing that seven had developed the disease.
- Most polyps identified were hyperplastic, but many patients also had dysplastic types, indicating a concerning association between polyps with dysplasia and cancer risk.
- Genetic changes were noted in some polyps, including mutations and microsatellite instability, hinting at underlying molecular mechanisms contributing to the increased cancer risk.