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Mitochondrial mRNA and the Small Subunit rRNA in Budding Yeasts Undergo 3'-End Processing at Conserved Species-specific Elements.
RNA
November 2024
Rowan University, Rowan-Virtua School of Osteopathic Medicine, Rowan-Virtua School of Translational
Article Synopsis
- Respiration in eukaryotes relies on mitochondrial protein synthesis, which is guided by organelle-specific ribosomes that translate mitochondrial mRNAs, although many details of this process remain unclear.
- Researchers mapped the 3' ends of mitochondrial mRNAs in different yeast species and identified sequence elements called 3'-end RNA processing elements (3'-RPEs), essential for processing mitochondrial RNA.
- The study highlights the role of the Rmd9 protein in this processing, showing its interaction with 3'-RPEs across various yeast species, and uncovers a unique translation mechanism involving removed stop codons in certain mRNAs.