Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation.

Prolonged exposure to interferon-gamma (IFNγ) and the associated increased expression of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1) create an intracellular shortage of tryptophan in the cancer cells, which stimulates ribosomal frameshifting and tryptophan to phenylalanine (W>F) codon reassignments during protein synthesis. Here, we investigated whether such neoepitopes can be useful targets of adoptive T cell therapy. Immunopeptidomic analyses uncovered hundreds of W>F neoepitopes mainly presented by the HLA-A24:02 allele.

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia.

Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive immune response, or an effective innate host response clearing Mycobacterium tuberculosis (Mtb) without adaptive immunity. In heavily exposed Indonesian tuberculosis household contacts (n = 1347), a persistently IGRA negative status was associated with presence of a BCG scar, and - especially among those with a BCG scar - with altered innate immune cells dynamics, higher heterologous (Escherichia coli-induced) proinflammatory cytokine production, and higher inflammatory proteins in the IGRA mitogen tube.

Daily routines, short-term priorities, and nurses' role hamper self-management support in a hospital setting: A mixed methods study.

Background: Self-management support is widely considered a critical aspect of nursing. Still, many studies indicate that nurses frequently experience difficulties in daily practice.

Objective: To gain a deeper understanding of the factors perceived by nurses to impede or promote their support of patients' self-management within the dynamic environment of the in-patient hospital setting.

Exploring six successful nurse-led transition clinics: Experiences and outcomes.

Background And Purpose: In the Netherlands, the 2022 Quality Standard 'Youth in transition from paediatric to adult care' underscores the importance of structured transitional care for young adults with chronic health conditions. Despite this emphasis, detailed knowledge about transition programs and their successful elements remains sparse. This study aims to bridge this gap by exploring nurse-led transition clinics that had successfully implemented core interventions such as a transition coordinator, warm handover, and individual transition plans.

Improving HIV testing and retention among adolescents and youths: Lessons from a quasi-experimental study of the Red-Carpet Program in Malawi.

Adolescents and youth living with HIV (AYLHIV) often face significant challenges in HIV care. Elizabeth Glaser Pediatric AIDS Foundation in Malawi implemented the Red-Carpet Program (RCP) to provide fast-tracked services for AYLHIV in care.This study aimed to assess the effect of RCP on Provider-Initiated HIV testing, linkage to care and antiretroviral therapy (ART), and retention in care among AYLHIV in Blantyre, Malawi.

From applause to disappointment - appreciation among healthcare providers that provided end-of-life care during the COVID-19 pandemic and its impact on well-being - a longitudinal mixed methods study (the CO-LIVE study).

Background: The healthcare sector is facing increasing work pressure, making a healthy workforce essential. Appreciation is a factor influencing well-being, and the COVID-19 pandemic offers valuable insights into this. This study aims to: 1) describe to what extent end-of-life care providers felt appreciated and understood during the first 18 months of the pandemic, 2) examine the impact of appreciation on their well-being, and 3) explore their perceptions of what appreciation should look like.

Effective student engagement with blended learning: A systematic review.

Although student engagement is known to promote learning outcomes in higher education, what elements of blended learning designs impact effective student engagement and hereby learning outcomes, has not been clarified yet. Hence, it is unknown how to engage students with blended learning in an effective manner. The current study breaks down student engagement into four dimensions (academic, behavioral, cognitive, and affective), and reviews the evidence regarding blended learning that engages students effectively, whether this is academically, personally, socially, or with regard to citizenship.

Home phototherapy for neonatal hyperbilirubinemia: current practices and attitudes.

Background: Neonatal hyperbilirubinemia is a leading cause of hospitalization during the first week of life. Recent research suggest that phototherapy, the standard treatment, can be safely and effectively administered at home. Some Dutch hospitals have already adopted home-based phototherapy.

Accuracy improvement in financial sanction screening: is natural language processing the solution?

Sanction screening is a crucial banking compliance process that protects financial institutions from inadvertently engaging with internationally sanctioned individuals or organizations. Given the severe consequences, including financial crime risks and potential loss of banking licenses, effective execution is essential. One of the major challenges in this process is balancing the high rate of false positives, which exceed 90% and lead to inefficiencies due to increased human oversight, with the more critical issue of false negatives, which pose severe regulatory and financial risks by allowing sanctioned entities to go undetected.

Perspectives on goal setting: Video-reflexive ethnography with speech-language therapists and clients.

Background: Goal setting is an essential step in the clinical reasoning process of speech and language therapists (SLTs) who provide care for children, adolescents and adults with communication disorders. In the light of person-centred care, shared or collaborative goal setting between the SLT and client is advised in (inter)national guidelines. SLTs face challenges in implementing (shared) goal setting as theoretical frameworks and practical interventions are scarce and less applicable to use with a wide range of communication vulnerable populations.

Exercise into Pain in Chronic Rotator Cuff-Related Shoulder Pain: A Randomized Controlled Trial with 6-Month Follow-Up.

Purpose: Exercise therapy is the first-line treatment in rotator cuff-related shoulder pain (RCRSP), and diverse types of exercise seem effective. However, it is not still clear if painful exercise should be allowed or avoided during exercises. The objective of this study was to investigate if exercise into pain is more effective than no pain in RCRSP.

Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer.

Messenger RNA (mRNA) translation is a tightly controlled process frequently deregulated in cancer. Key to this deregulation are transfer RNAs (tRNAs), whose expression, processing and post-transcriptional modifications are often altered in cancer to support cellular transformation. In conditions of limiting levels of amino acids, this deregulated control of protein synthesis leads to aberrant protein production in the form of ribosomal frameshifting or misincorporation of non-cognate amino acids.

Interleukin-10 inhibits important components of trained immunity in human monocytes.

Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is therefore needed to avoid pathology, but little is known about the endogenous processes that modulate it. Here, we investigated the potential of IL-10, a prototypical anti-inflammatory cytokine, to inhibit trained immunity.

'Please, see me'; Informal and professional support of students with relatives with addiction problems: a three-year longitudinal qualitative study.

Background And Aim: Addiction problems also affect the lives of family members. This study aims to examine: (1) young adult family members' experiences with informal and professional support in coping with the impact of relatives' addiction problems and (2) how these experiences evolve over time.

Method: A three-year longitudinal qualitative study.

Improving integrated care for (future) parents facing vulnerable circumstances in the early life course of their (future) child: An action research protocol.

Introduction: Suboptimal circumstances during the early life course, ranging from 100 days before conception to 1000 days following birth, significantly impact a child's future health and well-being. To optimize these circumstances, collaboration is needed which includes professionals working in medical, social and public domains, as well as parents. This action research protocol aims to improve care for (future) parents facing suboptimal circumstances during the early life course by enhancing inter-professional, cross-domain collaboration and (future) parents-professional collaboration.

Tasks and responsibilities of clinical midwives in Dutch hospitals.

Background: The number of Dutch clinical midwives has increased substantially over the last 20 years, but their tasks, responsibilities, and formal positions remain unclear. This study aimed to gain insight into the current tasks and responsibilities of clinical midwives in Dutch hospitals. We also aimed to determine whether these tasks varied among three types of hospitals in the Netherlands: secondary nonteaching hospitals, secondary teaching hospitals, and tertiary hospitals.

The relationship between fear of missing out, digital technology use, and psychological well-being: A scoping review of conceptual and empirical issues.

Given the rise of digital technology and its assumed impact on psychological well-being, this scoping review systematically examines the literature on Fear of Missing Out (FoMO), which is assumed to play a pivotal role in this dynamic. Although adverse effects of FoMO are commonly assumed, there is still no consensus on the nature of the phenomenon or its relations with psychological well-being and digital technology use, making a scoping review essential. To address this need, we comprehensively assess the conceptualizations of the construct of FoMO and its roles in relation to well-being and digital technology use.

Regulation of plasma soluble receptors of TNF and IL-1 in patients with COVID-19 differs from that observed in sepsis.

Objectives: IL-1α/β and TNF are closely linked to the pathology of severe COVID-19 and sepsis. The soluble forms of their receptors, functioning as decoy receptors, exhibit inhibitory effects. However, little is known about their regulation in severe bacterial and viral infections, which we aimed to investigate in this study.

Self-management support from health care providers in Shared Medical Appointments: Didactic techniques, peer learning, group dynamics and motivation.

Objective: We investigated the support of self-management by health care providers (HCP) in prenatal Shared Medical Appointments (SMA).

Methods: on an topic list, semi-structured interviews were conducted. HCP who provided prenatal care in SMA in the last five years were recruited.

Health-related quality of life in young adults with perinatal HIV after transfer to adult health care in the Netherlands.

Introduction: Health-related quality of life (HRQoL) in adult people with HIV is lower than that of the general population. Previously, no differences were detected in HRQoL of Dutch children with perinatal HIV (PHIV) compared to norm groups. In this study we compared HRQoL of PHIV young adults (PHIV-YA, aged 18-30) to two norm groups; the healthy Dutch YA population and YA with various chronic conditions.

RORα negatively regulates BCG-induced trained immunity.

Trained immunity is a long-lasting change in the responsiveness of innate immune cells, leading to a stronger response upon an unrelated secondary challenge. Epigenetic, transcriptional, and metabolic reprogramming contribute to the development of trained immunity. By investigating the impact of gene variants on trained immunity responses after Bacillus Calmette-Guérin (BCG) vaccination, we identified a strong association between polymorphisms in the RORA gene and BCG-induced trained immunity in PBMCs isolated from healthy human donors.

Working in smaller teams in community midwifery practices to foster continuity of carer: Midwives' experiences - A qualitative study in the Netherlands.

Background: Midwife-led continuity of carer (MLCC) improves health outcomes and increases pregnant women's satisfaction. Working in smaller teams in community midwifery practices is one of the ways to promote continuity of carer.

Aim: To gain insight into the experiences of Dutch community midwives regarding working in smaller teams, by identifying motivators and barriers.