Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients.

Lowering glucose levels, while avoiding hypoglycaemia, can be challenging in insulin-treated patients with diabetes. We evaluated the role of ambulatory glucose profile in optimising glycaemic control in this population. Insulin-treated patients with type 1 and type 2 diabetes were recruited into a prospective, multicentre, 100-day study and randomised to control (n = 28) or intervention (n = 59) groups.

A Novel Diagnostic Aid for Detection of Intra-Abdominal Adhesions to the Anterior Abdominal Wall Using Dynamic Magnetic Resonance Imaging.

Introduction. Abdominal adhesions can cause serious morbidity and complicate subsequent operations. Their diagnosis is often one of exclusion due to a lack of a reliable, non-invasive diagnostic technique.

Changing trends in the UK management of upper GI bleeding: is there evidence of reduced UK training experience?

Objective: The aim of this study was to evaluate UK trainee experience in endoscopy for acute upper gastrointestinal bleeding (AUGIB).

Methods: Data was prospectively collected from all patients presenting to South Yorkshire Hospitals with AUGIB from September 2011 to December 2011 and compared with data from 1996. Concurrently, all gastroenterology trainees registered with the British Society of Gastroenterology were invited to respond to a web-based questionnaire regarding their experience in AUGIB management.

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.

Ubiquitin-conjugating enzyme 9 (Ubc9) is required for sumoylation and inhibits apoptosis via Bcl-2 by unknown mechanism. Methionine adenosyltransferase 2A (MAT2A) encodes for MATα2, the catalytic subunit of the MATII isoenzyme that synthesizes S-adenosylmethionine (SAMe). Ubc9, Bcl-2 and MAT2A expression are up-regulated in several malignancies.

Effects of needs-based patient education on self-efficacy and health outcomes in people with rheumatoid arthritis: a multicentre, single blind, randomised controlled trial.

Objectives: The Educational Needs Assessment Tool (ENAT) is a self-completed questionnaire, which allows patients with arthritis to prioritise their educational needs. The aim of this study was to evaluate the effects of needs-based patient education on self-efficacy, health outcomes and patient knowledge in people with rheumatoid arthritis (RA).

Methods: Patients with RA were enrolled into this multicentre, single-blind, parallel-group, pragmatic randomised controlled trial.

Faecal calprotectin for differentiating between irritable bowel syndrome and inflammatory bowel disease: a useful screen in daily gastroenterology practice.

Objective: To determine the best faecal calprotectin (FCP) cut-off level for differentiating between irritable bowel syndrome (IBS) and organic disease, particularly inflammatory bowel disease (IBD), in patients presenting with chronic diarrhoea.

Design: Retrospective analysis of patients who had colonoscopy, histology and FCP completed within 2 months.

Setting: District general hospital.

Key Issues on Assuring the Safe Operation of Heath IT Systems.

The paper discusses the motivation behind the safety assurance of health IT, lists pertinent standards and regulation, as well as discussing prominent challenges in the field of health I safety.

Deviation based Safety Analysis and Justification of Clinical Services.

The paper describes safety analysis and justification of a clinical service (accidents and emergencies), using a deviation based approaches.

Warthin's tumour - Resolution following FNA.

This case report describes the acute presentation of a patient with a Warthin's tumour in his right parotid gland and complete resolution of the tumour following fine needle aspiration biopsy.

Open wound healing of the osseocutaneous fibula flap donor site.

Split skin grafts are the predominant method of closure for fibular flap donor sites. We present a novel approach to manage the donor site using the inter-related components of secondary intention healing: creation of a lattice to aid partial closure and compression dressings. The technique, which is widely used in dermatological surgery to manage cutaneous defects after operations for skin cancer, avoids the morbidity associated with the use of split skin grafts and enables early postoperative mobilisation.

Towards radiological diagnosis of abdominal adhesions based on motion signatures derived from sequences of cine-MRI images.

This paper reports novel development and preliminary application of an image registration technique for diagnosis of abdominal adhesions imaged with cine-MRI (cMRI). Adhesions can severely compromise the movement and physiological function of the abdominal contents, and their presence is difficult to detect. The image registration approach presented here is designed to expose anomalies in movement of the abdominal organs, providing a movement signature that is indicative of underlying structural abnormalities.

An unusual cause of persistent postpartum vaginal discharge.

We describe the case of a 27-year-old woman with a three-month history of persistent green vaginal discharge following vaginal delivery of her first child. Group C β-haemolytic streptococcus was ultimately isolated, which appears to be an uncommon cause of this clinical presentation.

Mature orbital teratoma presenting as a recurrent orbital cellulitis with an ectopic tooth and sphenoid malformation-a case report.

An unusual case of an orbital teratoma presenting as recurrent orbital cellulitis in a 2-year-old child. Imaging studies demonstrated an extraconal mass with a bony defect and a malformation of the sphenoid. An ectopic tooth was also present.

Lymphocytes treated by extracorporeal photopheresis demonstrate a drop in the Bcl-2/Bax ratio: a possible mechanism involved in extracorporeal-photopheresis-induced apoptosis.

Background: Recently, apoptosis has been identified in treated lymphocytes, prior to their re-infusion, when tested ex vivo. Previous work has demonstrated a close association between the genes p53, Bcl-2 and Bax and apoptosis induced by UV irradiation.

Objectives: We wanted to establish whether the expression of the protein product of these genes was altered in lymphocytes treated with extracorporeal photopheresis (ECP) prior to re-infusion and therefore possibly implicated in the early apoptosis observed.

D-dimer assay for deep vein thrombosis: its role with colour Doppler sonography.

Aim: To evaluate the role of a negative D-dimer assay in the initial management of patients with clinically suspected deep venous thrombosis (DVT), using colour Doppler ultrasound as the primary diagnostic technique.

Materials And Methods: A double-blind prospective trial was performed on 143 patients with clinically suspected DVT. All patients underwent a D-dimer assay prior to anticoagulant therapy.

Review of investigative diagnostic techniques for cutaneous lymphoma.

This article reviews the contribution of modern investigative techniques to the diagnosis of cutaneous lymphoproliferative diseases. Special attention is given to the significance of immunoglobulin and T-cell receptor rearrangements; as detected by Southern blotting and/or the polymerase chain reaction. Additional topics discussed include immunohistochemistry, cytogenetics, onco- and tumour suppressor genes and in-situ hybridization.