6 results match your criteria: "Roswell Park Comprehensive Cancer Center (Roswell Park)[Affiliation]"
Spatiotemporal assessment of immunogenomic heterogeneity in multiple myeloma.
Blood Adv
March 2023
Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY.
Spatial heterogeneity is a common phenomenon in metastatic solid tumors and an evolving concept in multiple myeloma (MM). The interplay between malignant plasma cells (PCs) and the microenvironment has not yet been analyzed in MM. For this purpose, we performed bone marrow aspirates and imaging-guided biopsies of corresponding lesions in newly diagnosed MM (NDMM) and relapsed/refractory MM (RRMM) patients.
View Article and Find Full Text PDFIn Vivo Models for Studying Interstitial Photodynamic Therapy of Locally Advanced Cancer.
Methods Mol Biol
May 2022
Photodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Interstitial photodynamic therapy (I-PDT) is a promising therapy considered for patients with locally advanced cancer. In I-PDT, laser fibers are inserted into the tumor for effective illumination and activation of the photosensitizer in a large tumor. The intratumoral light irradiance and fluence are critical parameters that affect the response to I-PDT.
View Article and Find Full Text PDFDeciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma.
Nat Commun
February 2022
Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Article Synopsis
- Osteolytic lesions (OL) in multiple myeloma are influenced by malignant plasma cells (PC), but the reasons for varying bone destruction in different regions remain unclear.
- A study using single-cell RNA sequencing analyzed 148,630 PC from various sites in 10 patients, revealing significant inter- and intra-patient variability.
- Findings indicate that PC from OL express different genes compared to those from bone marrow, highlighting specific gene changes related to bone disease and showing transcriptional shifts post-induction therapy.
Irradiance, Photofrin Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models.
Photochem Photobiol
March 2020
Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY.
The objective of the present study was to develop a predictive model for Photofrin -mediated interstitial photodynamic therapy (I-PDT) of locally advanced tumors. Our finite element method was used to simulate 630-nm intratumoral irradiance and fluence for C3H mice and New Zealand White rabbits bearing large squamous cell carcinomas. Animals were treated with light only or I-PDT using the same light settings.
View Article and Find Full Text PDFAn Optical Surface Applicator for Intraoperative Photodynamic Therapy.
Lasers Surg Med
July 2020
Department of Cell Stress Biology, Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), 665 Elm St., Buffalo, New York, 14203.
Article Synopsis
- - The study focused on developing a novel optical surface applicator (OSA) for intraoperative photodynamic therapy (IO-PDT) to improve control over light distribution, which is important for tissue and tumor treatment.
- - The OSA was made from flexible silicone with diffusing optical fibers, and its light distribution was tested both directly on the applicator and through tissue-simulating phantoms using a dosimetry system.
- - Results showed improved uniformity of light distribution in phantoms compared to the OSA surface, and the OSA successfully delivered the intended light dose in a pilot study with swine, indicating its potential for effective therapy in clinical settings.
Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer.
Br J Cancer
November 2018
Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Background: Currently delivered light dose (J/cm) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced cancer. The aim of this study was to investigate the impact of light dose rate (irradiance, mW/cm) and associated heating on tumour response and cure.
Methods: Finite-element modeling was used to compute intratumoural irradiance and dose to guide Photofrin I-PDT in locally advanced SCCVII in C3H mice and large VX2 neck tumours in New Zealand White rabbits.