2 results match your criteria: "Rostov-on-Don Research Institute for Plague Control[Affiliation]"
Genomic history of the seventh pandemic of cholera in Africa.
Science
November 2017
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Article Synopsis
- The seventh cholera pandemic has significantly impacted Africa, with its origins and spread not fully understood.
- Researchers analyzed genomic data from 1070 cholera O1 isolates across 45 African countries over 49 years, finding that past epidemics came from a single expanded lineage introduced multiple times since 1970.
- Recent introductions consisted of drug-resistant sublineages from Asia, emphasizing the need for targeted cholera control measures based on the identified patterns of spread.
Ultrastructural Changes in the Intestine of Suckling Rabbits Infected with Cholerogenic and Non-Cholerogenic nonO1/nonO139 Vibrio cholerae Strains.
Bull Exp Biol Med
September 2015
Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia.
We performed an electron microscopic study of the small intestine of suckling rabbits infected with cholerogenic and non-cholerogenic strains nonO1/nonO139 Vibrio cholerae. Cholerogenic strain induced mostly hydropic degeneration of the epithelium typical of cholera toxin effect, while non-cholerogenic strain induced the formation of lacunae along the borders of adjacent epithelial cells typical of hemagglutinin/protease effect. In both cases, reduction of microvilli, destruction of intracellular organelles, two types of mitochondrial reaction (condensation and swelling with destruction of cristae), appearance of myelin figures, defects in the capillary walls, and activation of pinocytosis were observed.
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