Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs.

The self-assembly of amyloid-β peptide (Aβ) into fibrils and oligomers is linked to Alzheimer's disease (AD). Fibrillar aggregates in AD patient's brains contain several post-translational modifications, including phosphorylation at positions 8 and 26. These play a key role in modifying the aggregation propensity of Aβ, yet how they affect the mechanism of aggregation is only poorly understood.

A decade of outsourcing in health and social care in England: What was it meant to achieve?

The increased private provision of publicly funded health and social care over the last 75 years has been one of the most contentious topics in UK public policy. In the last decades, health and social care policies in England have consistently promoted the outsourcing of public services to private for-profit and non-profit companies with the assumption that private sector involvement will reduce costs and improve service quality and access. However, it is not clear why outsourcing often fails to improve quality of care, and which of the underlying assumptions behind marketising care are not supported by research.

Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles.

Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

Evaluation of a complex couplet care intervention in a neonatal intensive care unit: A mixed methods study protocol.

Background: Families with an infant in need of intensive care most often experience a harmful separation after birth. This is due to a division of medical specialties into neonatal care and maternal care. Therefore, a couplet care intervention is implemented for mother-infant dyads in a neonatal intensive care unit.

Protocol: Interventions aimed at preventing out-of-home placement of children: A systematic review.

This is the protocol for a Campbell systematic review. The objectives are as follows. The aim of the present review is to synthesize evidence on the effectiveness of interventions for at-risk families aimed at preventing the out-of-home placement of children or increasing the likelihood that children are reunited with their birth families following temporary care arrangements.

Modeling the impact of COVID-19 nonpharmaceutical interventions on respiratory syncytial virus transmission in South Africa.

Background: The South African government employed various nonpharmaceutical interventions (NPIs) to reduce the spread of SARS-CoV-2. Surveillance data from South Africa indicates reduced circulation of respiratory syncytial virus (RSV) throughout the 2020-2021 seasons. Here, we use a mechanistic transmission model to project the rebound of RSV in the two subsequent seasons.

The Nordic governments' responses to the Covid-19 pandemic: A comparative study of variation in governance arrangements and regulatory instruments.

Government responses to the Covid-19 pandemic in the Nordic states-Denmark, Finland, Iceland, Norway, and Sweden-exhibit similarities and differences. This article investigates the extent to which crisis policymaking diverges from normal policymaking the Nordic countries and whether variations the countries are associated with the role of expertise and the level of politicization. Government responses are analyzed in terms of governance arrangements and regulatory instruments.

Intergrading reef communities across discrete seaweed habitats in a temperate-tropical transition zone: Lessons for species reshuffling in a warming ocean.

Temperate reefs are increasingly affected by the direct and indirect effects of climate change. At many of their warm range edges, cool-water kelps are decreasing, while seaweeds with warm-water affinities are increasing. These habitat-forming species provide different ecological functions, and shifts to warm-affinity seaweeds are expected to modify the structure of associated communities.

Droplet digital PCR as a tool for investigating dynamics of cryptic symbionts.

Interactions among symbiotic organisms and their hosts are major drivers of ecological and evolutionary processes. Monitoring the infection patterns among natural populations and identifying factors affecting these interactions are critical for understanding symbiont-host relationships. However, many of these interactions remain understudied since the knowledge about the symbiont species is lacking, which hinders the development of appropriate tools.

Drawing lessons from the COVID-19 pandemic: Seven obstacles to learning from public inquiries in the wake of the crisis.

On March 11, 2020, the World Health Organization declared the emerging COVID-19 threat a pandemic following the global spread of the virus. A year later, a number of governments are being handed the concluding reports of national public inquiries tasked with investigating responses, mishaps, and identifying lessons for the future. The present article aims to identify a set of learning obstacles that may hinder effective lessons drawing from the COVID-19 pandemic responses.

Patient-centeredness in Physiotherapy - A literature mapping review.

Background And Purpose: Research on patient-centeredness within physiotherapy points to a need for clarification about what the concept entails in science and practice and how research positions itself within health care. Thus, the aim is to systematically map the characteristics of research on patient-centeredness in physiotherapy and critically discuss the dominant understandings within.

Methods: A systematic research mapping was carried out, based on searches in leading bibliographic databases.

Seasonal genetic variation associated with population dynamics of a poecilogonous polychaete worm.

Poecilogonous species show variation in developmental mode, with larvae that differ both morphologically and ecologically. The spionid polychaete shows variation in developmental mode not only between populations, but also seasonally within populations. We investigated the consequences of this developmental polymorphism on the spatial and seasonal genetic structure of at four sites in the Danish Isefjord-Roskilde-Fjord estuary at six time points, from March 2014 until February 2015.

A Novel pAA Virulence Plasmid Encoding Toxins and Two Distinct Variants of the Fimbriae of Enteroaggregative .

Enteroaggregative (EAEC) is an increasingly recognized pathogen associated with acute and persistent diarrhea worldwide. While EAEC strains are considered highly heterogeneous, aggregative adherence fimbriae (AAFs) are thought to play a pivotal role in pathogenicity by facilitating adherence to the intestinal mucosa. In this study, we optimized an existing multiplex PCR to target all known AAF variants, which are distinguished by differences in their pilin subunits.

Segregation of chromosome arms in growing and non-growing Escherichia coli cells.

In slow-growing Escherichia coli cells the chromosome is organized with its left (L) and right (R) arms lying separated in opposite halves of the nucleoid and with the origin (O) in-between, giving the pattern L-O-R. During replication one of the arms has to pass the other to obtain the same organization in the daughter cells: L-O-R L-O-R. To determine the movement of arms during segregation six strains were constructed carrying three colored loci: the left and right arms were labeled with red and cyan fluorescent-proteins, respectively, on loci symmetrically positioned at different distances from the central origin, which was labeled with green-fluorescent protein.

Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production.

During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.

If You Know Something, Say Something: Young Children's Problem with False Beliefs.

Whether young children understand that others may hold false beliefs is a hotly debated topic in psychology and neuroscience. Much evidence suggests that children do not pass this milestone in their understanding of other people until the age of 5 years. Other evidence suggests that they understand already in their second year.