1 results match your criteria: "Roskamp Institute University of South Florida[Affiliation]"
A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease.
Neurology
September 2000
Roskamp Institute University of South Florida, Tampa, FL 33613, USA.
Objective: To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD.
Design: A case-control genetic association study of a Caucasian dataset of 309 clinic- and community-based cases and 134 community-based controls.
Results: The authors find a signficant interaction between the GG genotype of CST3 and age/age of onset on risk for AD, such that in the over-80 age group the GG genotype contributes two-fold increased risk for the disease.