Innovative ultrasound assisted synthesis of sponge like cerium dioxide nanostructure using Rosa Damascena extract and its efficient performance for cancer therapy.

In this work, cerium dioxide nanostructures were synthesized in an easy sonochemical way. CeO nanoparticles have received much attention in nanotechnology. CeONPs, exhibit biomimetic properties depending on their size, ratio of valency on their surface, and the ambient physico-chemical properties.

Home high-flow therapy during recovery from severe chronic obstructive pulmonary disease (COPD) exacerbation: a mixed-methods feasibility randomised control trial.

Introduction: Patients recovering from severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a 30-day readmission rate of 20%. This study evaluated the feasibility of conducting a randomised controlled trial to evaluate clinical, patient-reported and physiological effects of home high-flow therapy (HFT) in addition to usual medical therapy, in eucapnic patients recovering from AECOPD to support the design of a phase 3 trial.

Methods: A mixed-methods feasibility randomised controlled trial (quantitative primacy, concurrently embedded qualitative evaluation) (ISRCTN15949009) recruiting consecutive non-obese patients hospitalised with AECOPD not requiring acute non-invasive ventilation.

Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids.

Keloids are pathological scars characterized by excessive fibroblast proliferation, abnormal collagen deposition, and chronic inflammation, which often result in high recurrence rates and limited treatment success. Targeting BACH1 with gene therapy has shown promise in regulating fibroblast activity and reducing inflammation. However, effective delivery systems for targeted gene therapy in keloids remain a major challenge.

Hyaluronan Directs Alveolar Type II Cell Response to Acute Ozone Exposure in Mice.

Becoming more frequent due to climate change, ozone (O) exposures can cause lung injury. Alveolar type 2 (AT2) cells and hyaluronan (HA), a matrix component, are critical to repairing lung injury and restoring homeostasis. Here, we define the impact of HA on AT2 cells following acute O exposure.

Effectiveness of targeted social and behavior change communication on maternal health knowledge, attitudes, and institutional childbirth: a cluster-randomized trial in Jimma Zone, Ethiopia.

Maternal mortality remains a critical global health challenge, with 95% of deaths occurring in low-income countries. While progress was made from 2000 to 2015, regions such as Ethiopia continue to experience high maternal mortality rates, impeding the achievement of the sustainable development goal to reduce maternal deaths to 70 per 100 000 live births by 2030. This study evaluated the effectiveness of a Social and Behavior Change Communication (SBCC) intervention to improve maternal health behaviors.

Influenza vaccine effectiveness against medically attended outpatient illness, United States, 2023-24 season.

Background: The 2023-24 U.S. influenza season was characterized by a predominance of A(H1N1)pdm09 virus circulation with co-circulation of A(H3N2) and B/Victoria viruses.

Long-Acting Injectable Antipsychotics in Adolescents with Bipolar Disorder.

Bipolar disorder often begins in adolescence or early adulthood, characterized by recurrent manic episodes that can lead to neurodegenerative brain changes and functional decline. While several oral second-generation antipsychotics are Food and Drug Administration (FDA)-approved for mania, adherence to maintenance treatment is frequently poor due to factors such as anosognosia, cognitive dysfunction, impulsivity, side effects aversion, and substance use. Long-acting injectable (LAI) antipsychotics, approved for adults with bipolar mania or schizoaffective disorder (bipolar type), offer a potential solution for adolescents with similar conditions.

DFT investigation of green stabilizer reactions: curcumin in nitrocellulose-based propellants.

Context: Nitrocellulose, widely used in energetic materials, is prone to thermal and chemical degradation, compromising safety and performance. Stabilizers are molecules used in the composition of nitrocellulose-based propellants to inhibit the autocatalytic degradation process that produces nitrous gases and free nitric acids. Curcumin, (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, known for its antioxidant properties and a potential green stabilizer, was investigated using Density Functional Theory (DFT) focusing on its interaction with nitrogen dioxide.

Exploring the impact of sodium acetate on lipid and carotenoid production in .

The study employed batch shake flasks to evaluate the impact of various nitrogen sources, phosphate levels, and sodium acetate (Na-acetate) on the growth and metabolite production. Adding Na-acetate to the medium resulted in significant improvements in critical metabolites. In shake flask experiments, this led to a cell dry weight (CDW) of 1.

Oncocytic Carcinoma Ex-Pleomorphic Adenoma of the Lacrimal Gland.

Oncocytic carcinoma is a rare malignant neoplasm of oncocytic cells, such cells being characterized by abundant granular eosinophilic cytoplasm, invasive growth, and pronounced cellular pleomorphism. It may arise de novo, or through malignant transformation of a pre-existing benign oncocytoma. Oncocytic carcinoma most commonly occurs in the salivary glands, with rare involvement of the ocular adnexa where it mainly affects caruncle, conjunctiva, and lacrimal sac, and only very arises in the lacrimal gland.

Rapid degeneration and neurochemical plasticity of the lateral geniculate nucleus following lesions of the primary visual cortex in marmoset monkeys.

Lesions of the primary visual cortex (V1) cause retrograde neuronal degeneration, volume loss and neurochemical changes in the lateral geniculate nucleus (LGN). Here we characterised the timeline of these processes in adult marmoset monkeys, after various recovery times following unilateral V1 lesions. Observations in NeuN-stained sections obtained from animals with short recovery times (2, 3 or 14 days) showed that the volume and neuronal density in the LGN ipsilateral to the lesions were similar to those in the contralateral hemispheres.

Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015).

Background: Insulin resistance (IR) is an important risk factor for multiple chronic diseases, increasing mortality and reducing life expectancy. The associations between emerging surrogates for IR, triglyceride-glucose index (TyG) and TyG-related indicators, with all-cause mortality and life expectancy in middle-aged and older patients in primary care are unclear.

Methods: This study originated from the Polish primary care cohort LIPIDOGRAM2015, including patients aged ≥45 years.

Assessing the efficiency of danacid as corrosion inhibitor for aluminium in HCl medium: Experimental, theoretical and optimization studies.

The present study examined the corrosion protection of aluminium in 1M HCl by deploying expired danacid, with techniques such as gravimetric, electrochemical, and density functional theory (DFT). Inhibitor characterization was executed with Fourier transform infrared (FTIR) spectroscopy and gas chromatography mass spectrometry (GC-MS), which was supplemented by optimization of parameters with response surface methodology. The results of gravimetric study indicates that the inhibition efficiency (IE) rose with rise in danacid concentration and reduced with rise in temperature.

Transcriptomic effects of alginate hydrogel applied to the production of bovine embryos.

-produced blastocysts are exposed to different stimuli when compared with ones. This includes the culture of embryos in a sturdy petri-dish, while embryos develop in a soft and dynamic structure. Here we hypothesized that a softer environment could differently modulate the produced embryos To that aim, presumptive zygotes were produced by fertilization and divided into three groups: 1) Cultured in a regular Petri dish - Control (CON); 2) Cultured on top of an alginate hydrogel surface (TOP); 3) Encapsulated inside an alginate hydrogel sphere (ENC) and cultured.

Level of interest among Belgian consumers of the cultural, environmental, ethical, and global benefits of sustainable beekeeping management.

This study aimed to explore the consumers' level of interest in environmental, ethical, cultural, and global claims associated with sustainable beekeeping management and identify which factors influence perceptions of sustainable management and honey purchase. 1100 Belgian respondents were surveyed on their honey purchasing behavior and interest in the benefits of sustainable beekeeping management, complemented with socio-demographic questions. The data were evaluated using descriptive, non-parametric and multivariate statistics.

Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 cells with gut tropism.

Activated CD4 T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4 T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR activated dendritic cells (DCs) is unknown.

Sustainable superhydrophobic lignin-based polyurethane foam: an innovative solution for oil pollutant adsorption.

Green, efficient treatment of crude oil spills and oil pollutants is a global challenge, with adsorption technology favored for its efficiency and low environmental impact. The development of an environmentally friendly adsorbent with high hydrophobicity, excellent adsorption performance, and degradability is crucial to overcoming the limitations of petroleum-based adsorbents. Here, a lignin-based polyurethane foam (LPUF) with superhydrophobic and photothermal oil-absorbing properties was fabricated by incorporating octadecyltrimethoxysilane into the foam system.

Effect of Ar on Temperature and Flow Distribution in Monocrystalline Graphene Growth: Inert Gas Is Active.

Monocrystalline graphene growth has always been an intriguing research focus. Argon (Ar) is merely viewed as a carrier gas due to its inert chemical properties throughout the whole growth procedure by the chemical vapor deposition method. In this work, the influence of Ar on temperature and flow fields was investigated in consideration of its physical parameter difference among all involved gases.

Characteristics, Contamination Levels, and Ecosystem Risk Assessment of Microplastics in Surface Water of a Highly Urbanized River from a Developing Country.

Microplastic (MP) contamination poses significant risks to ecosystems and human health. However, the absence of standardized protocols, detailed polymer identification, and sources identification hinders the development of targeted mitigation strategies, particularly in developing nations. There is a scarcity of comprehensive data on MP distribution, sources, and transport mechanisms in freshwater environments.

Pembrolizumab and axitinib induced pathological complete response in metastatic clear cell renal cell carcinoma with inferior vena cava thrombus: A case report.

Clear cell renal cell carcinoma is the predominant subtype of kidney cancer. With distant metastasis, the overall survival rate for patients with renal cell carcinoma decreases significantly compared to localized disease. However, pembrolizumab plus axitinib combination is safe and improves long-term survival.

Is the Current Lights-Off Time in General Hospitals Too Early, Given People's Usual Bedtimes?

Objective: This study aimed to investigate how shift-working nursing professionals perceive the current lights-off time in wards as early, appropriate, or late and how their perceptions can be influenced when considering people's usual bedtimes.

Methods: An online survey was conducted comprising queries about the current lights-off time in wards and respondents' opinions, self-rated psychological status, and perceptions of the current lights-off time considering others' usual bedtimes. Psychological status was evaluated using the Insomnia Severity Index, the Patient Health Questionnaire-9, the Dysfunctional Beliefs and Attitudes about Sleep-16, and the Discrepancy between Desired Time in Bed and Desired Total Sleep Time (DBST) Index, along with the expected DBST Index of others.

The Impact of Helicopter Parenting on Emerging Adults in Higher Education: A Scoping Review of Psychological Adjustment in University Students.

This scoping review explored the recent literature on the relationship between helicopter parenting and psychological adjustment among emerging adults in a university setting. A literature search was conducted on PubMed, Scopus, Web of Science, and PsycINFO to identify all original peer-reviewed studies published between 2020 and 2024 in English that examined the association between helicopter parenting and indices of psychological distress among college students. Twenty-three studies were included in this review.

Passive Isothermal Flexible Sensor Enabled by Smart Thermal-Regulating Aerogels.

Environmentally induced sensor temperature fluctuations can distort the outputs of a sensor, reducing their stability during long-term health monitoring. Here, a passive isothermal flexible sensor is proposed by using hierarchical cellulose aerogel (HCA) as the top tribonegative layer, which allows the sensor to adapt dynamic thermal environments through both radiative cooling and heat insulation. The radiative cooling effect can cool down the temperatures of a sensor in summer, while the hollow microfibers in HCA provide ultralow thermal conductivity to reduce internal heat loss in winter.

Electrospun adsorbent membrane of PLA containing chitosan for toxic metal ions removal from aqueous solution: Effect of chitosan incorporation.

The scarcity of water resources and their pollution are vital to modern civilization. Thus, adsorptive membranes are promising candidates to be applied in the filtration systems to improve the water quality. In summary, this study investigated the effect of chitosan (CS) in the morphological, chemical, and physical aspects of PLA-based membranes incorporating chitosan obtained by electrospinning process, their adsorption behavior in multielement aqueous systems containing Cr, Cu, Zn, Mn , Ni, and Cd in pH 4, and the possible removal mechanism on the composite electrospun membrane's surface.