5,496 results match your criteria: "Rosacea"
Isosilybin A exhibits anti-inflammatory properties in rosacea by inhibiting MAPK pathway and M1 macrophage polarization.
Int Immunopharmacol
December 2024
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China; Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, Guangdong Province, China. Electronic address:
Rosacea is a chronic inflammatory skin disease, which is prone to flares and requires continuous management and treatment. However, long-term use of drugs can lead to additional adverse drug reactions. Based on the comorbid relationship between rosacea and Parkinson's disease, bioinformatics and network pharmacology analysis were used to identify a safer drug for rosacea.
View Article and Find Full Text PDFExploring the association between skin microbiota and inflammatory skin diseases: a two-sample Mendelian randomization analysis.
Arch Dermatol Res
October 2024
Department of Clinical Nutrition, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Dysbiosis in the skin microbiome is closely associated with various inflammatory skin diseases. However, current research on the causal relationship between the skin microbiome and inflammatory skin diseases lacks comprehensive and detailed investigation. We used a two-sample Mendelian randomization (MR) approach to explore associations between the skin microbiome and seven inflammatory skin diseases, including acne, atopic dermatitis, erysipelas, vitiligo, psoriasis, rosacea, and urticaria.
View Article and Find Full Text PDFScalp Rosacea Treated with Topical Ivermectin.
Skin Appendage Disord
October 2024
Dermatology Clinic, University of Catania, Catania, Italy.
Article Synopsis
- Scalp rosacea is frequently misdiagnosed and lacks approved treatments, making it a challenge for healthcare professionals.
- A case study of 5 adults with scalp rosacea showed positive results using ivermectin 1% cream applied daily for 12 weeks.
- The findings indicate that assessing the scalp during rosacea evaluations is important and suggest that ivermectin may be an effective treatment option for scalp rosacea.
Skin-permeable gold nanoparticles with modifications azelamide monoethanolamine ameliorate inflammatory skin diseases.
Biomark Res
October 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Article Synopsis
- Traditional treatments for inflammatory skin diseases have poor penetration and side effects, leading researchers to explore metal nanoparticles as a better solution.!
- A new type of gold nanoparticle, Au-MEA NPs, was developed, showing improved stability and effectiveness in treating conditions like psoriasis and rosacea in animal studies.!
- Au-MEA NPs work by reducing inflammation in skin cells, making them a promising option for safe topical treatment of inflammatory skin diseases. !
Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea.
Nat Commun
October 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article Synopsis
- Rosacea is a chronic skin condition, and this study reveals that unique cell changes in the skin of affected patients may involve a specific type of keratinocyte damaged by IFNγ signaling.* -
- Research indicates that rosacea is characterized by an increase in various inflammatory cells and dysfunctional vascular cells, which contribute to its symptoms.* -
- Fibroblasts are identified as central players in producing inflammatory signals related to rosacea, and targeting these cells could be a potential strategy for treating the condition.*
Evaluation of Benzene Presence and Formation in Benzoyl Peroxide Drug Products.
J Invest Dermatol
October 2024
Valisure, LLC, New Haven, Connecticut, USA; Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Long Island, New York, USA.
Article Synopsis
- - Benzoyl peroxide (BPO), commonly used in acne treatments, can degrade into benzene, a harmful carcinogen, especially when stored or used at high temperatures.
- - A study detected varying levels of benzene (0.16 to 35.30 ppm) in 111 over-the-counter BPO products when kept at room temperature, while a prescription version showed none at low temperatures but significant benzene at high temperatures.
- - Experiments revealed that using BPO on skin models can lead to detectable benzene levels in the air, especially under UV light, highlighting health risks from benzene exposure regardless of the initial concentration in the products.
Investigation of Factors Associated with Gut Microbiota in -associated Skin Conditions.
Turkiye Parazitol Derg
October 2024
Dokuz Eylül University Hospital, Department of Dermatology, İzmir, Türkiye.
Article Synopsis
- This study examines the links between gut microbiota factors and skin conditions like demodicosis, rosacea, and perioral dermatitis in 113 patients.
- Researchers found that alcohol consumption and smoking were significant risk factors for these skin issues, along with low water intake and infrequent exercise.
- The findings suggest that environmental and lifestyle choices can influence these skin conditions, highlighting the need for further exploration into their management and potential treatments.
Differences in the Clinical Characteristics of Male Patients With Different Ages of Rosacea: A Retrospective Study of 215 Male Outpatients.
J Cosmet Dermatol
January 2025
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Background: Rosacea is more common in women and Caucasians, leading to little research on rosacea in Asian men. Additionally, there is limited research on the patients across different age groups.
Aims: The aim of this study is to analyze and compare the characteristics of male patients of rosacea among different age groups.
Usability evaluation and reporting for mobile health apps targeting patients with skin diseases: a systematic review.
Clin Exp Dermatol
January 2025
Oxford University Hospitals NHS Foundation Hospitals, Dermatology Department, Churchill Hospital, Headington, Oxford, UK.
Article Synopsis
- Usability is crucial for mobile health apps, especially for skin disease patients, yet many apps lack proper design and evaluation.
- The study analyzed the usability of 9 mobile health apps, finding that most were easy to use and effective, with major concerns around navigation, security, and customizability.
- Acknowledging the gap between rapid app development and limited usability research, the study calls for improved user-centered design and thorough evaluation to enhance the adoption of these health apps.
IL-17A-neutralizing antibody ameliorates inflammation and fibrosis in rosacea by antagonizing the CXCL5/CXCR2 axis.
FASEB J
October 2024
Clinical Medical College, North China University of Science and Technology, Tangshan, China.
Article Synopsis
- Rosacea is a chronic skin condition that can lead to fibrosis, but the detailed mechanisms of this fibrosis, especially in later stages, are not well understood.
- The study investigated the role of IL-17A-neutralizing antibodies in treating rosacea-like lesions in mice, finding they helped reduce skin damage and inflammation.
- Results showed that these antibodies decreased several inflammatory and fibrosis-related factors, indicating they may effectively inhibit processes that contribute to rosacea-related skin issues.
Optimizing Dermatological Care Triage in a Safety-Net Hospital: Retrospective Analysis of Diagnoses and In-Person Referrals.
South Med J
October 2024
From the Department of Dermatology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Article Synopsis
- Teledermatology offers a cost-effective solution for patients with limited access to dermatological care, needing assessment of its optimization in safety-net hospitals.
- A study reviewed 1502 e-consultations over two years, involving a diverse patient group, with a significant portion being Medicaid recipients and Black or African American individuals.
- Results indicated that most patients were managed via e-consultation without needing in-person visits, although children and those with specific complaints like hair loss required more face-to-face evaluations.
A case of Morbihan disease treated with ivermectin.
Int J Dermatol
March 2025
Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.
Article Synopsis
- Cleansing is crucial for preventing infections, but it can be tricky for those with skin conditions since traditional cleansers might damage the skin barrier while removing dirt and oils.
- This study assessed a new foaming gel cleanser made with polymeric surfactant technology on 85 individuals with sensitive skin for four weeks.
- Results indicated significant improvements in skin comfort and appearance without irritation, suggesting this cleanser is effective and gentle for sensitive skin types.
HArmonyCa™ hybrid filler to restore connective tissue: An Italian real-life retrospective study.
J Cosmet Dermatol
December 2024
Scientific Writing, Torgiano (PG), Italy.
Article Synopsis
- HArmonyCa™ is a new hybrid dermal filler combining hyaluronic acid and calcium hydroxylapatite, aimed at improving facial aging and skin conditions.* -
- The study involved 129 patients who underwent HArmonyCa™ treatment, with outcomes evaluated nine months post-treatment using both physician and patient satisfaction assessments.* -
- Results indicated significant improvements in facial appearance and movement, with only minor adverse effects reported, demonstrating the treatment's safety and compatibility with other cosmetic interventions.*
Development of Indian Council of Medical Research (ICMR) Standard Treatment Workflows for Skin Diseases: A Step Toward Universal Health Coverage.
Indian Dermatol Online J
July 2024
Secretary to Government of India, Department of Health Research, and Director General, ICMR New Delhi, India.
Article Synopsis
- Skin conditions are prevalent but poorly managed, especially due to a shortage of dermatologists and unequal healthcare access between urban and rural areas.
- The objective was to create standard treatment workflows (STWs) for common skin diseases to help healthcare providers at all levels deliver better care.
- Thirteen modules covering various skin conditions were developed and are now available as posters in health centers and online, aiming to improve the treatment of skin diseases throughout the healthcare system.
Signaling pathways and targeted therapy for rosacea.
Front Immunol
October 2024
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- - Rosacea is a common, chronic skin condition affecting 1% to 20% of the global population, marked by symptoms like facial redness, small bumps, and potential eye issues, caused by a blend of genetic, environmental, and immune factors.
- - Recent research highlights specific molecular mechanisms involved in rosacea, such as the roles of LL37, TLR2, and mTOR pathways, which help activate immune cells and produce inflammatory cytokines, ultimately driving inflammation and blood vessel growth.
- - Current treatments for rosacea aim at managing symptoms, but new understanding of its underlying biology is paving the way for more precise therapies, including drugs that target particular cytokines and signaling pathways like IL-17 and JAK.
Tranexamic Acid for the Treatment of Hyperpigmentation and Telangiectatic Disorders Other Than Melasma: An Update.
Clin Cosmet Investig Dermatol
September 2024
The Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Article Synopsis
- - Tranexamic acid (TXA) is primarily an antifibrinolytic agent used to control bleeding in trauma and surgeries, and it also helps prevent bleeding in hemophilia patients.
- - Recent studies suggest TXA has additional benefits like reducing pigmentation, inflammation, and promoting skin recovery, leading to its exploration as a treatment for various skin issues.
- - The review focuses on TXA's effectiveness for conditions like post-inflammatory hyperpigmentation and rosacea, advocating for its potential use beyond melasma as a safer, cost-effective treatment option.
Incidence of rosacea after placement of intrauterine devices: a retrospective analysis.
Arch Dermatol Res
September 2024
Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA, USA.
An Oral Botanical Supplement Improves Small Intestinal Bacterial Overgrowth (SIBO) and Facial Redness: Results of an Open-Label Clinical Study.
Nutrients
September 2024
Integrative Skin Science and Research, Sacramento, CA 95815, USA.
Article Synopsis
- - The study investigates the effects of an herbal treatment on gut microbiome, facial redness, and intestinal permeability in adults diagnosed with small intestinal bacterial overgrowth (SIBO) confirmed by a lactulose breath test.
- - Participants underwent a 10-week regimen of a Biocidin liquid tincture and GI Detox+, with additional treatment via Olivirex if they showed no improvement, monitored through breath tests and other analyses.
- - Results indicated that the herbal regimen was particularly effective for certain types of SIBO, with 42.8% of participants showing improvement in hydrogen-dominant cases and significant increases in beneficial bacteria over the treatment period.
The Prevalence of spp. Infestation in Dermatological Patients in Northern Poland.
Life (Basel)
September 2024
Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, University Clinical Centre, 80-214 Gdańsk, Poland.
Article Synopsis
- - The study examined the prevalence of *spp.* mites in 2508 patients from northern Poland suspected of having demodicosis, with a total of 3684 tests conducted.
- - Only 43.02% of the tests confirmed the presence of *spp.*, showing a positive correlation with the patient's age and higher detection rates on eyelids and facial skin.
- - Men were found to have *spp.* more often than women, and effective diagnosis of demodicosis remains challenging due to vague symptoms and low confirmation rates, particularly among younger patients.
Off-Label Uses of Abrocitinib: Review of Emerging Therapeutic Applications beyond Atopic Dermatitis.
Life (Basel)
September 2024
Department of Otorhinolaryngology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Article Synopsis
- Abrocitinib is a JAK1 inhibitor mainly approved for treating moderate-to-severe atopic dermatitis in those 12 and older, but this review explores its off-label uses.
- Researchers found 37 studies using Abrocitinib for conditions beyond atopic dermatitis, with common cases including vitiligo, prurigo nodularis, and hand eczema, each having 12 reported instances.
- All but one of the 103 patients studied experienced favorable outcomes with Abrocitinib, highlighting its potential for treating multiple skin conditions.
Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study.
Life (Basel)
August 2024
Department for Respiratory Infections, University Hospital for Infectious Diseases "Dr. Fran Mihaljević", 10000 Zagreb, Croatia.
Article Synopsis
- Periocular dermatitis is an inflammatory skin condition around the eyes, with unclear causes, possibly linked to the skin microbiome, prompting this study to compare microbiota between affected individuals and healthy controls.
- The study involved 35 patients with periocular dermatitis and 39 healthy people who provided skin swabs; DNA was extracted and analyzed using advanced sequencing technology.
- Results showed significant differences in bacterial diversity between the groups, with certain bacteria more abundant in patients, suggesting that changes in the skin microbiota may play a role in the development of periocular dermatitis and warrant further research.
The Clinical Efficacy of Lapachol in Facial Redness Reduction.
J Cosmet Dermatol
November 2024
Dermatology Consulting Services, PLLC, High Point, North Carolina, USA.
Background: Facial erythema from acne, vascular rosacea, or photoaging is a common difficult-to-treat dermatologic challenge.
Objective: The objective of this study was to examine the role of lapachol in alleviating facial erythema associated with a variety of common dermatologic conditions.
Methods: Twenty-five healthy female and male subjects 35-65 years of age of Fitzpatrick skin types I-II with mild-to-moderate stable facial erythema from acne, rosacea or photoaging were enrolled in a single-site monadic study.
Rosacea and Gastrointestinal Diseases: A Case-Control Study in the All of Us Database.
Dermatology
December 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Article Synopsis
- * Researchers studied 8,319 people with rosacea and compared them to 33,276 others without it to see if there was a connection.
- * They found that people with rosacea were more likely to have certain gut diseases, but there was no strong link to a condition called microscopic colitis.
Honey Phytochemicals: Bioactive Agents With Therapeutic Potential for Dermatological Disorders.
Phytother Res
December 2024
Plant Biochemistry and Food Quality Group, Environmental and Biochemical Sciences Department, The James Hutton Institute, Dundee, Scotland.
Article Synopsis
- * The phytochemicals in honey, including flavonoids and phenolic acids, demonstrate a variety of beneficial properties like anti-inflammatory, antiaging, and antioxidant effects relevant to skin health.
- * While current studies show promise for honey's potential in treating dermatological disorders, further high-quality research is needed to confirm its clinical efficacy as a bioactive agent or cosmeceutical.