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Rosacea Publications | LitMetric

5,496 results match your criteria: "Rosacea"

Objective: To investigate the role of NEAT1 targeted regulation of miR-125/ADAM9 mediated NF-κB pathway in inflammatory response in rosacea.

Method: HaCaT cell rosacea phenotype was induced by LL37. The connection targeted by NEAT1 and miR-125a-5p was confirmed by Double-Luciferase report analysis.

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Positive results of intense pulsed light-photodynamic therapy for moderate-to-severe rosacea: A prospective, single-arm study.

J Am Acad Dermatol

November 2024

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, P. R. China. Electronic address:

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Article Synopsis
  • * It discusses various skin conditions linked to Parkinson's, like seborrheic dermatitis and autoimmune diseases, suggesting possible shared biological mechanisms.
  • * The review also emphasizes the role of skin biopsies in diagnosing these diseases, particularly identifying biomarkers like α-synuclein, which could lead to improved diagnostic methods and a more comprehensive understanding of Lewy body disease.
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Purpose: The purpose of this study was to report the outcomes of quantum molecular resonance (QMR) electrotherapy in the management of refractory pediatric ocular rosacea.

Methods: This is a retrospective case series on 3 female pediatric patients (ages 12, 15, 14 years) with ocular rosacea. Two patients presented with corneal stromal neovascularization and punctate epithelial erosions while 1 patient presented with corneal scarring and paracentral stromal thinning.

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Article Synopsis
  • Demodex mites are the most common ectoparasites found on humans and usually coexist harmlessly in hair follicles and oil glands.
  • However, if their population increases excessively, they can lead to various eye issues (like blepharitis and ocular rosacea) and skin conditions (such as rosacea and seborrheic dermatitis).
  • Recognizing the role of Demodex in these conditions is vital for proper diagnosis and treatment, which may include specific therapies aimed at reducing the mite population and alleviating symptoms.
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A combination of benzoyl peroxide (BPO) and tretinoin is recommended for treating acne; however, concurrent administration can be irritating, and coformulation is prevented by BPO-mediated oxidation of tretinoin. In rosacea, benzoyl peroxide has been shown to be efficacious; however, its use has been limited by poor tolerability. To overcome these limitations, the active ingredients can be encapsulated within silica microcapsules.

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Objective: To assess the effectiveness and safety of treating erythematotelangiectatic rosacea using fractional radiofrequency (FRF).

Methods: Twenty patients with a confirmed diagnosis of erythema capillaris rosacea were selected, and one side of each patient's face was randomly assigned to receive FRF treatments for three to six times, with an interval of 2 weeks between each treatment. VISIA, dermoscopy, and the Clinician's Erythema Evaluation Scale (CEA) were applied to evaluate the efficacy of the treatment before and after the treatment, to record the VAS scores and adverse reactions, and to conduct a patient satisfaction survey.

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Article Synopsis
  • Rosacea is a chronic skin condition that causes inflammation, burning, and aesthetic changes on the face, and Liang Xue Wu Hua Tang (LXWHT) is a traditional herbal treatment used clinically for it, although its mechanisms are not well understood.
  • The study aimed to explore how LXWHT works against rosacea using network pharmacology and molecular docking techniques, identifying 43 active compounds and 28 potential therapeutic targets connected to the condition.
  • Key findings suggested that LXWHT may help treat rosacea by affecting immune pathways and identified core therapeutic targets and active ingredients, indicating a need for further research on its efficacy.
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Introduction: Prior research has explored the relationship between inflammatory skin disorders and breast cancer (BC), yet the causality of this association remains uncertain.

Methods: Utilizing a bidirectional two-sample Mendelian randomization (MR) approach, this study aimed to elucidate the causal dynamics between various inflammatory skin conditions-namely acne, atopic dermatitis, psoriasis vulgaris, urticaria, and rosacea-and BC. Genetic variants implicated in these disorders were sourced from comprehensive genome-wide association studies representative of European ancestry.

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Health-related Quality of Life of Patients with Rosacea: A Systematic Review and Meta-analysis of Real-world Data.

Acta Derm Venereol

June 2024

Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Research center of big data and meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Patients with rosacea commonly experience stigmatization, which induces stress and thereby exacerbates their symptoms. Given the strong effects of rosacea on health-related quality of life (HRQoL), addressing the physical and psychosocial aspects of rosacea is essential. To examine the effects of rosacea on HRQoL, we conducted a systematic review and meta-analysis involving real-world data.

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The most prevalent skin condition is acne vulgaris. Recent clinical practice guidelines recommend oral isotretinoin to treat moderate-to-severe acne. The aim of this study is to assess the knowledge, attitude, and risk perception of oral isotretinoin for acne treatment.

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Light Therapy for Facial Rejuvenation and Dry Eyes, Blepharitis, and Styes.

Int Ophthalmol Clin

July 2024

Director of Oculofacial Plastic Surgery, University of Southern California Keck School of Medicine, USC Roski Eye Institute, Los Angeles, CA.

Intense pulsed light has a growing body of research supporting its use in skin rejuvenation, dermatologic conditions, as well as ocular rosacea, dry eyes and meibomian gland dysfunction. This paper will start with the conception of one protocol for treating dry eyes, blepharitis and styes using broad band light, a version of intense pulsed light, and its evolution into a life-changing in-office procedure for many patients. The approach for optimizing the settings, considerations during the consultation, the procedure in detail, after treatment care, and potential complications to avoid are all explained.

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Targeting the STAT3/IL-36G signaling pathway can be a promising approach to treat rosacea.

J Adv Res

June 2024

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: Rosacea is an inflammatory skin disorder characterized by the release of inflammatory mediators from keratinocytes, which are thought to play a crucial role in its pathogenesis. Despite an incidence of approximately 5.5%, rosacea is associated with a poor quality of life.

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Rosacea: Common Questions and Answers.

Am Fam Physician

June 2024

UPMC St. Margaret Family Medicine Residency Program, Pittsburgh, Pennsylvania.

Article Synopsis
  • - Rosacea is a common chronic skin condition that primarily affects the face, impacting about 5% of the population, with its exact cause still unknown.
  • - Diagnosis follows guidelines from the National Rosacea Society, focusing on symptoms like redness, skin thickening, and bumps, but delays in treatment may arise for individuals with darker skin tones.
  • - Management involves daily skin care routines and topical treatments, while systemic options may be used for more severe cases; the condition can affect a patient's emotional well-being, and referrals are advised for specific complications.
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Article Synopsis
  • Cannabidiol (CBD) from hemp shows promise in treating acne due to its anti-inflammatory and lipid-modulating properties, as discovered through recent experiments.
  • The studies found that higher concentrations of CBD reduced cell viability in sebocytes (SEB-1) and keratinocytes (HaCaT), induced apoptosis, and decreased pro-inflammatory cytokines like CXCL8 and IL-1α.
  • CBD also inhibited lipid synthesis by affecting the AMPK-SREBP-1 pathway and promoted the production of skin proteins like elastin and collagen, highlighting its potential for managing acne effectively.
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Background Internalized stigma (IS) is the acceptance of unfavorable stereotypes about the disease that society has created and withdrawing from society with feelings of shame and worthlessness. Due to the visibility feature of facial skin diseases such as rosacea and acne vulgaris (AV), it is possible for them to cause IS. Objective We aimed to examine the level of IS in AV and rosacea patients and compare these patient groups as well.

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Introduction: Rosacea is a chronic inflammatory skin condition associated with erythema, inflammation and skin sensitivity.

Objectives: To assess the benefit of a dermocosmetic cream (DC cream) containing Sphingobioma xenophaga extract and soothing agent in adult females with rosacea-associated erythema and sensitive skin.

Materials And Methods: During phase 1, DC was applied twice daily on the randomized half-face and compared to usual-skincare (USC) for 28 days.

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Article Synopsis
  • Ocular rosacea can be misdiagnosed due to the lack of reliable diagnostic tests and may present with symptoms like recurrent chalazion and dry eyes without facial redness.* -
  • A 63-year-old woman experienced multiple chalazion that recurred even after surgical removal, and her condition was associated with significant chronic inflammation as seen in pathology studies.* -
  • Treatment with oral antibiotics doxycycline and azithromycin led to resolution of symptoms, highlighting the need for ophthalmologists to consider skin diseases when diagnosing ocular issues.*
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A Case of Complex Giant Rhinophyma Treated With Cosmetic Surgery.

Ann Plast Surg

August 2024

From the Department of Plastic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, China.

Rhinophyma leads to severe facial deformities and significant social pressure for patients. Patients often seek medical intervention due to cosmetic defects and functional impairments, such as nasal congestion and airway collapse. Currently, there are numerous treatment modalities for rhinophyma, each with distinct advantages and disadvantages, leading to a lack of consensus in nasal vegetation management.

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