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Smoking Paradox in Patients Hospitalized With Coronary Artery Disease or Acute Ischemic Stroke: Findings From Get With The Guidelines.

Circ Cardiovasc Qual Outcomes

October 2015

From the Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston (S.F.A., L.H.S.); Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada (E.E.S.); Department of Epidemiology and Biostatistics, Michigan State University, East Lansing (M.J.R.); Duke Clinical Research Institute, Durham, NC (X.Z., Y.X., A.F.H.); Division of Cardiology, Brigham and Women's Hospital Heart and Vascular Institute, Boston, MA (D.L.B.); Harvard Medical School, Boston, MA (D.L.B.); and Division of Cardiology, Ronald Reagan-UCLA Medical Center (G.C.F.).

Background: Smoking is a potent risk factor for coronary artery disease (CAD) and acute ischemic stroke (AIS), but there are numerous reports of lower in-hospital mortality among smokers versus nonsmokers hospitalized for these events.

Methods And Results: We analyzed all consecutive patients hospitalized with a first index CAD (n=158 054) or AIS (n=899 295) event in Get With The Guidelines from 2002 to 2012; 20.4% of AIS and 30.

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