Modulating the p53-MDM2 pathway: the therapeutic potential of natural compounds in cancer treatment.

The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal point of cancer research. This literature review delves into the complex interplay between the tumor suppressor protein p53 and its main regulator MDM2, highlighting their interaction and implications in cancer development and progression. The review compiles and summarizes the existing understanding of the biology and regulation of p53 and MDM2, emphasizing their roles in various cellular processes, including cell cycle regulation, DNA repair, apoptosis, and metabolism.

Psychological factors associated with Long COVID: a systematic review and meta-analysis.

Background: Despite the immense impact of Long COVID on public health and those affected, its aetiology remains poorly understood. Findings suggest that psychological factors such as depression contribute to symptom persistence alongside pathophysiological mechanisms, but knowledge of their relative importance is limited. This study aimed to synthesise the current evidence on psychological factors potentially associated with Long COVID and condition-relevant outcomes like quality of life.

Application of response surface methodology in the formulation of spreadable creams from beechnut seeds as sustainable ingredient.

Plants available in the spontaneous flora are recently studied as ingredients for food formulation in response to the demands for sustainable plant-based foods. The aim of this study was to obtain a new assortment of spreadable creams, free of palm oil, with good textural, rheological and colour attributes, high antioxidant activity and low cytotoxicity, from . (European beech) seeds.

Development and evaluation of a simulation-based early-mobility curriculum for paediatric intensive care nurses.

Background: Early mobility is one strategy to reduce the harm from immobility that children experience in the paediatric intensive care unit (PICU). Early-mobility programmes rely on nurses, who currently perceive insufficient training as a barrier to mobilizing critically ill children. Nurses have identified simulation as a strategy to improve implementation of early-mobility protocols.

Investigations on the synthesis and characterization of silver-doped MoO thin films for photocatalytic applications.

In this study, we aimed to enhance the photocatalytic performance of molybdenum oxide (MoO) thin films by doping with silver (Ag) via a spray pyrolysis technique. The primary objective for silver incorporation was intended to introduce additional energy levels into the band structure of MoO, improving its efficiency. Structural, optical, and photocatalytic properties were analyzed using X-ray diffraction (XRD) and optical spectroscopy.

Thermal Actuators Relying on Elastomer-Dispersed Liquid Crystals: From Imines with Supramolecular Chirality and Ferroelectricity to Soft Robots.

The locomotion of various organisms relies on the alternated elongation-contraction of their muscles or bodies. Such biomimicry can offer a promising approach to developing soft robotic devices with improved mobility and efficiency. Most strategies to mimic such motions rely on reversible size modifications of some materials upon exposure to external stimuli.

Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects.

Cancer therapy continues to face critical challenges, including drug resistance, recurrence, and severe side effects, which often compromise patient outcomes and quality of life. Exploring novel, cost-effective approaches, this review highlights the potential of Piper nigrum (black pepper) extract (PNE) as a complementary anticancer agent. Piper nigrum, a widely available spice with a rich history in traditional medicine, contains bioactive compounds such as piperine, which have demonstrated significant anticancer activities including cell cycle arrest, apoptosis induction, and inhibition of tumor growth and metastasis.

Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences?

Background: There is a lack of information on the current healthcare systems for children with kidney diseases across Europe. The aim of this study was to explore the different national approaches to the organization and delivery of pediatric nephrology services within Europe.

Methods: In 2020, the European society for Paediatric Nephrology (ESPN) conducted a cross-sectional survey to identify the existing pediatric nephrology healthcare systems in 48 European countries covering a population of more than 200 million children.

Analyzing the cyberbullying phenomenon on social media from the perspective of students.

Introduction: With the significant increase in the number of social media users, the degree of cyberbullying has also increased in a directly proportional manner. Cyberbullying manifests itself in the commission of psychological abuses, teenagers being the most vulnerable.

Methods: The purpose of our paper was to analyze how the phenomenon of cyberbullying manifests in terms of frequency on social media platforms, while taking into account factors such as gender, and elements related to the behavior/reactions of witnesses and victims.

Investigating the effect of geopolitical risk on defense companies' stock returns.

This study examines the influence of geopolitical risk (GPR) on the stock returns of 75 global representative defense companies. Our argument is based on the premise that the Crimean Peninsula's 2014 annexation was a turning point for the defense industry. The study uses wavelet coherence and phase differences to examine daily datasets spanning from January 1, 2014 to December 31, 2023.

Inflammation and oxidative stress processes in induced precocious puberty in rats.

This study aimed to assess the influence of different types of blue light sources on male and female rats' puberty onset, the morphologic-induced alterations in reproductive organs tissues, the impact on inflammation and oxidative stress markers, anxiety levels, and mathematical modeling for tissue data interpretation. Four groups of sixteen rats each (8 females and 8 males/group) were investigated: three groups were exposed to blue light from mobile phones (MP), computer screens (PC), or LED lamps (LED) versus the control group (CTRL). The rats in the CTRL group had no exposure while the other groups were exposed for 30 days to the blue light of MP, PC, and LED for 16 h per day.

An atypical presentation of Wernicke-Korsakoff encephalopathy mimicking a left hemispheric stroke: case report.

Background: Wernicke-Korsakoff encephalopathy is a metabolic disease caused by vitamin B1 deficiency that predominantly affects alcoholic patients. Its clinical picture is characterized mainly by altered mental status with memory deficits, ophthalmoparesis, and ataxia, although other clinical manifestations may also be present. The current case presents certain clinical difficulties regarding the diagnosis when confronting an atypical presentation of a classical disease in an acute setting when a decision to administer an intravenous thrombolytic agent needs to be made.

On the existence of solutions to fractional differential equations involving Caputo -derivative in Banach spaces.

The generalization of BVPs always covers a wide range of equations. Our choice in this research is the generalization of Caputo-type fractional discrete differential equations that include two or more fractional -integrals. We analyze the existence and uniqueness of solutions to the multi-point nonlinear BVPs base on fixed point theory, including fixed point theorem of Banach, Leray-nonlinear Schauder's alternative, and Leray-degree Schauder's theory.

Enhanced Efficiency of Sequential Cutting Balloon Angioplasty in Calcified Coronary Artery Disease: The RODIN-CUT Technique.

Background: Heavily calcified coronary artery disease presents significant challenges in percutaneous coronary intervention (PCI), often requiring advanced techniques to achieve optimal outcomes. Cutting balloons (CB) have shown potential for plaque modification; however, their effectiveness is limited without standardized protocols.

Aims: This study introduces the RODIN-CUT technique, a novel approach utilizing sequential CB inflations with real-time intravascular ultrasound (IVUS) guidance.

Cerebral iron accumulation in multiple sclerosis: Pathophysiology and therapeutic implications.

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration. Recent studies highlight the role of cerebral iron (Fe) accumulation in exacerbating MS pathophysiology. Fe, essential for neural function, contributes to oxidative stress and inflammation when dysregulated, particularly in the brain's gray matter and demyelinated lesions.

Ultrasensitive detection and quantification of bovine Deltapapillomavirus in the semen of healthy horses.

BPV1, BPV2, BPV13, and BPV14 are all genotypes of bovine delta papillomaviruses (δPV), of which the first three cause infections in horses and are associated with equine sarcoids. However, BPV14 infection has never been reported in equine species. In this study, we examined 58 fresh and thawed commercial semen samples from healthy stallions.

Textbook outcome in liver surgery for intrahepatic cholangiocarcinoma: defining predictors of an optimal postoperative course using machine learning.

Background: We sought to define textbook outcome in liver surgery (TOLS) for intrahepatic cholangiocarcinoma (ICC) by considering the implications of perioperative outcomes on overall survival (OS).

Methods: Using a multi-institutional database, TOLS for ICC was defined by employing novel machine learning (ML) models to identify perioperative factors most strongly predictive of OS ≥ 12 months. Subsequently, clinicopathologic factors associated with achieving TOLS were investigated.

Ethylene glycol toxicosis in 39 sport horses following ingestion of contaminated water: a case report.

Ethylene glycol toxicosis is a common occurrence in dogs and cats but has been reported in other species as well. Up to date, only one case of ethylene glycol toxicosis has been described in horses, and specific guidelines for treating ethylene glycol intoxication in this species are not available. Here we describe the case of 39 sport horses that ingested water contaminated with ethylene glycol.

European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.

Introduction: Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for structural, toxic and metabolic disorders is negative, digestive motility and gut-brain interaction disorders should be assessed.

Trigeminal artery anatomical aspects.

Purpose And Background: The trigeminal artery is a rare anatomical variant, representing an embryonic vestige of the anastomosis between the internal carotid artery and the posterior circulator system, that can be asymptomatic or could have vast clinical manifestations produced by insufficient flow or by vascular nervous conflicts. This study is an anatomical presentation of 3 trigeminal artery cases observed at Medimar Imagistic Services Constanta.

Methods: The 3 trigeminal artery cases were discovered on a 860 magnetic resonance angiographies (0.

Long-term impact of tillage on microbial communities of an Eastern European Chernozem.

As conservation agricultural practices continue to spread, there is a need to understand how reduced tillage impacts soil microbes. Effects of no till (NT) and disk till (DT) relative to moldboard plow (MP) were investigated in a long-term experiment established on Chernozem. Results showed that conservation practices, especially NT, increased total, active and microbial biomass carbon.

Machine learning based prediction model for bile leak following hepatectomy for liver cancer.

Objective: We sought to develop a machine learning (ML) preoperative model to predict bile leak following hepatectomy for primary and secondary liver cancer.

Methods: An eXtreme Gradient Boosting (XGBoost) model was developed to predict post-hepatectomy bile leak using data from the ACS-NSQIP database. The model was externally validated using data from hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) multi-institutional databases.

The Mediating Role of Commercial FOMO Between Adolescents' Need to Belong and Psychological Distress: Advertising Implications on Mental Health.

The present study was designed to investigate the impact of advertising on adolescents' mental health. To achieve this, we sought to test the mediating effect of commercial fear of missing out (FOMO) related to gadgets and clothing items on the relationship between the need to belong and psychological distress. The research was conducted on a sample of 335 Romanian adolescents (54.