A comprehensive review of structure-function correlations in age-related macular degeneration: Contributions of microperimetry.

Age-related macular degeneration (AMD) is a leading cause of visual impairment and irreversible blindness worldwide. High-resolution imaging techniques have been pivotal in characterizing the morphological alterations in the retina and in identifying structural biomarkers with prognostic significance. In clinical practice, visual function is primarily assessed through visual acuity testing, which, however, does not completely reflect the functional deficits experienced by patients.

ExerGeneDB: A physical exercise-regulated differential gene expression database.

Background: Exercise induces molecular changes that involve multiple organs and tissues. Moreover, these changes are modulated by various exercise parameters-such as intensity, frequency, mode, and duration-as well as by clinical features like gender, age, and body mass index (BMI), each eliciting distinct biological effects. To assist exercise researchers in understanding these changes from a comprehensive perspective that includes multiple organs, diverse exercise regimens, and a range of clinical features, we developed Exercise Regulated Genes Database (ExerGeneDB), a database of exercise-regulated differential genes.

Shear wave elastography for thyroid nodule evaluation in patients with chronic autoimmune thyroiditis.

Purpose: Shear wave elastography (SWE) is a valuable tool in discerning the malignancy risk of thyroid nodules. This study investigates whether 2D-SWE can reliably differentiate malignant thyroid nodules in patients with chronic autoimmune thyroiditis (CAT), despite the challenges posed by fibrosis, which can increase tissue stiffness and complicate diagnosis.

Methods: This retrospective observational study evaluated 130 thyroid nodules (91 benign, 39 malignant) in patients with underlying CAT using conventional ultrasound (B-mode) and 2D-SWE with SuperSonic Mach30 equipment (Supersonic Imagine, Aix-en-Provence, France).

Light energy-driven carbonic anhydrase mediate CO sequestration system with variable-temperature adaptability.

The escalating atmospheric CO₂ concentration urgently demands ecologically friendly mitigation strategies. Compared to alternative catalysts, carbonic anhydrase (CA) demonstrates exceptionally high catalytic efficiency in CO₂ hydration reactions. Nevertheless, traditional CA immobilization techniques exhibit peak enzymatic activity exclusively at optimal temperatures, consequently constraining their effective application across diverse environmental thermal conditions in industrial settings.

Morphological assessments of the oropharyngeal isthmus in professional singing.

and Aims We conducted this research motivated by the incomplete knowledge of the changes made by resonance and harmonic filtering processes made by articulatory gestures in the supralar-yngeal level of the vocal tract. Aim of research The goal of the study is to evaluate the adaptive changes taking place at the oropharyngeal isthmus during sustained phonation. Methods We focused on exploring the dynamics of the oropharyngeal pavilion in voice professionals using Cone-Beam Computed Tomogra-phy (CBCT).

Up-front resection for hepatocellular carcinoma: Assessing futility in the preoperative setting.

Objective: We sought to develop a predictive model to preoperatively identify patients with hepatocellular carcinoma (HCC) at risk of undergoing futile upfront liver resection (LR).

Methods: Patients undergoing curative-intent LR for HCC were identified from a large multi-institutional database. Futile LR was defined by death or disease recurrence within six months postoperatively.

Does Perfectionism Affect Parental Identity Development? A One-Year Longitudinal Study.

Introduction: Previous studies have revealed that perfectionism and identity development during adolescence are related. However, no longitudinal study has been conducted on the impact of perfectionism on identity development in adulthood. In the present study, we analyzed for the first time the longitudinal relationship between personal standards, an indicator of perfectionistic strivings, and concern over mistakes and doubts about actions, indicators of perfectionist concerns, and identity development in one of the most important yet least understood domains for adults, parental identity.

Management Measures and Trends of Biological Invasions in Europe: A Survey-Based Assessment of Local Managers.

Biological invasions are a major threat to biodiversity, ecosystem functioning and nature's contributions to people worldwide. However, the effectiveness of invasive alien species (IAS) management measures and the progress toward achieving biodiversity targets remain uncertain due to limited and nonuniform data availability. Management success is usually assessed at a local level and documented in technical reports, often written in languages other than English, which makes such data notoriously difficult to collect at large geographic scales.

ENHANCED RESTORATION OF VISUAL CODE AFTER TARGETING ON BIPOLAR CELLS COMPARED TO RETINAL GANGLION CELLS WITH OPTOGENETIC THERAPY.

Optogenetic therapy is a promising vision restoration method where light sensitive opsins are introduced to the surviving inner retina following photoreceptor degeneration. The cell type targeted for opsin expression will likely influence the quality of restored vision. However, a like-for-like pre-clinical comparison of visual responses evoked following equivalent opsin expression in the two major targets, ON bipolar (ON BCs) or retinal ganglion cells (RGCs), is absent.

Periorificial dermatitis in infants and preschoolers - a narrative review.

Periorifical dermatitis (POD) is a papular, chronic inflammatory skin disease commonly seen in women in their 2nd to 4th decade of life. The major differential diagnosis is persistent acne. In children, POD is less common than in adults.

The effect of a general practitioner's perception of a patient request for antibiotics on antibiotic prescribing for respiratory tract infections: secondary analysis of a point prevalence audit survey in 18 European countries.

Background: Illness severity, comorbidity, fever, age and symptom duration influence antibiotic prescribing for respiratory tract infections (RTI). Non-medical determinants, such as patient expectations, also impact prescribing.

Aim: To quantify the effect of general practitioners' (GPs') perception of a patient request for antibiotics on antibiotic prescribing for RTI and investigate effect modification by medical determinants and country.

Alkenyl pheromones: Raman spectroscopic analysis, DFT modeling, and machine learning for stereoisomerism evaluation.

Alkenyl pheromones are a class of insect sex pheromones that are characterized by the presence of one or more double bonds, which can be either in the E(trans) or Z(cis) configuration. This structural variation is essential in mating, as it influences reproductive behavior and provides a potential method for insect control. As a base for rapid and in-situ screening of synthetic pheromones or pheromone-based products, this study explores the potential of Raman spectroscopy to differentiate between the two geometrical isomers, E(trans) and Z(cis), of the alkenyl pheromones.

Deep Eutectic Solvents Meet Non-Aqueous Cosolvents: A Modeling and Simulation Perspective-A Tutorial Review.

Deep eutectic solvents (DESs) have recently gained attention due to their tailorable properties and versatile applications in several fields, including green chemistry, pharmaceuticals, and energy storage. Their tunable properties can be enhanced by mixing DESs with cosolvents such as ethanol, acetonitrile, and water. DESs are structurally complex, and molecular modeling techniques, including quantum mechanical calculations and molecular dynamics simulations, play a crucial role in understanding their intricate behavior when mixed with cosolvents.

Efficiency of carbon dioxide capture with metal substitutions in the MIL-88A metal-organic framework.

Carbon dioxide capture is a vital approach for mitigating air pollution and global warming. In this context, metal-organic frameworks are promising candidates. Particularly, MIL-88A (M), where the metal nodes (M) are connected to fumarate linkers in its structure, has demonstrated significant potential for CO capture.

Marginal mandibular branch of the facial nerve - anatomical peculiarities and clinical aspects.

Background: The expanding number of parotid ablations, reconstructive and aesthetic surgeries of the head and neck, considerably increased the risk of the marginal mandibular branch (MMB) injury. The purpose of our study was to determine the anatomical peculiarities of the MMB depending on the facial nerve branching pattern (FNBP), gender and cephalometric type.

Materials And Methods: The MMB was dissected on 75 hemiheads of adult embalmed cadavers.

Frustration Intolerance Scale for Students.

Background: Frustration intolerance (FI) is the belief that reality should meet our desires for ease, pleasure and comfort. Although extensively studied in adults, tools for measuring FI in children and adolescents are scarce. The Frustration Intolerance Scale for Students (FISS) was developed to fill this gap.

Global Potential Geographic Distribution of Anthonomus eugenii Under Climate Change: A Comprehensive Analysis Based on an Ensemble Modeling Approach.

Climate warming is affecting the ranges and population dynamics of invasive species, including insects, which have become a global problem, causing biodiversity declines and agricultural economic losses. Anthonomus eugenii as an important invasive pest on pepper is now mainly located in the USA and Mexico. However, the global potential geographic distribution (PGD) of A.

qEEG Neuromarkers of Complex Childhood Trauma in Adolescents.

Complex childhood trauma (CCT) involves prolonged exposure to severe interpersonal stressors, leading to deficits in executive functioning and self-regulation during adolescence, a critical period for neurodevelopment. While qEEG parameters, particularly alpha oscillations, have been proposed as potential biomarkers for trauma, empirical documentation in developmental samples is limited. .

Current strategies in design and synthesis of antifungals hybrid and chimeric diazine derivatives.

In the last decades fungal infections became a major threat to human health having an unacceptably occurrence, a high rate of mortality and the number of patients at risk for these infections continue to increase every year. An effective, modern and very useful strategy in antifungal therapy is represented by the use of chimeric and hybrid drugs, most of them being with azaheterocycle skeleton. In this review, we present an overview from the last five years of the most representative achievements in the field of chimeric and hybrid diazine derivatives with antifungal properties.

Facile preparation of bifunctional monolayers through diazonium grafting and "click" postfunctionalization: A first step towards efficient aptasensing interfaces.

Herein, we present an efficient approach for developing electrochemical aptasensing interfaces, by "click" postfunctionalization of phenylethynyl-grafted glassy carbon substrates with mixed monolayers containing biorecognition elements and phosphorylcholine zwitterionic groups. Typically, controlling the composition of multicomponent surface layers by grafting from a mixture of aryldiazonium salts is challenging due to differences in their chemical reactivity. Our approach circumvents this issue by employing the electrochemical reduction of a single aryldiazonium salt containing a silyl-protected alkyne group followed by deprotection, to create phenylethynyl monolayers which can subsequently accommodate the concurrent immobilization of bioreceptors and zwitterionic groups through "click" postfunctionalization.

Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma.

Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11% in the United States. As for other types of tumors, such as colorectal cancer, aberrant lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and progression.

Aim: To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid (FA) import into cell.

Sex Disparities in Ischemic Heart Disease Mortality in Europe.

Background: Ischemic heart disease (IHD) is the leading cause of death in the European Union (EU). Understanding variations by sex, income, and countries can help in tailoring effective public health policies.

Objectives: The purpose of the study was to examine trends in sex differences in IHD prevalence and prognosis within the EU.

Practices, strategies, and challenges in antibiotic treatment and prevention of antimicrobial resistance from the perspectives of Romanian community pharmacists and general practitioners: a Goffman-inspired qualitative interview study.

Introduction: Antimicrobial resistance (AMR) represents a persistent and ascensive global threat influenced by antibiotic misuse and overuse. In the Romanian context, patterns of antibiotic consumption and resistance within the healthcare system are marked in the red scenario on the European map. General practitioners and pharmacists, among others, play a major role in stewardship towards AMR.