Influence of outer membrane permeabilization on intrinsic resistance to the hydrophobic biocide triclosan in opportunistic species.

Triclosan is a hydrophobic antimicrobial agent commonly employed in health care settings. While it exhibits broad-spectrum antibacterial properties, the gram-negative nosocomial opportunists and are atypically refractory. Intrinsic resistance to triclosan in is largely due to its outer membrane impermeability properties for hydrophobic and bulky substances.

A Small Molecule That In Vitro Neutralizes Infection of SARS-CoV-2 and Its Most Infectious Variants, Delta, and Omicron.

The COVID-19 pandemic has underscored the urgent need to develop highly potent and safe medications that are complementary to the role of vaccines. Specifically, it has exhibited the need for orally bioavailable broad-spectrum antivirals that are able to be quickly deployed against newly emerging viral pathogens. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and its variants Delta and Omicron are still a major threat to patients of all ages.

Lessons from digital technology-enabled health interventions implemented during the coronavirus pandemic to improve maternal and birth outcomes: a global scoping review.

Background: Timely access to essential obstetric and gynecologic healthcare is an effective method for improving maternal and neonatal outcomes; however, the COVID-19 pandemic impacted pregnancy care globally. In this global scoping review, we select and investigate peer-reviewed empirical studies related to mHealth and telehealth implemented during the pandemic to support pregnancy care and to improve birth outcomes.

Methods: We searched MEDLINE and PubMed, Scopus, CINAHL and Web of Science for this Review because they include peer-reviewed literature in the disciplines of behavioral sciences, medicine, clinical sciences, health-care systems, and psychology.

Inter-element variation in the bone histology of (Dinocephalia, Anteosauridae) from the Assemblage Zone of the Karoo Basin of South Africa.

Despite its abundance in the Permian fossil record of South Africa, little is known about the life history of . Here we examine the bone microstructure of multiple skeletal elements of from the Assemblage Zone of the Karoo Basin. The bone histology of reveals that the cortex is composed of highly vascularized, uninterrupted fibrolamellar bone tissue surrounding the inner spongy medullary region.

Education in Mathematics and the Spread of COVID-19.

We investigate the effect of standardized mathematics scores for young adults on the number of COVID-19 cases in the USA. We find that a one-grade-level increase in test scores led to a decrease in COVID-19 cases 30, 60, and 90 days after the first case in each county. Our findings suggest that if states and localities implement policies that increase the level of education and comprehension of mathematics at the K-12 level, that people may be better prepared to find and interpret information in a future public health crisis.

Physical Activity of Arab Muslim Mothers of Young Children Living in the United States: Barriers and Influences.

Objectives: To examine physical activity (PA) levels, and how sociocultural factors, acculturation, self-efficacy and religion influence PA levels of Arab Muslim mothers of young children living in the United States.

Participants And Setting: Arab Muslim mothers of young children (aged <5 years) living in the United States (N=447).

Variables Measured: PA levels, sociocultural and religious barriers to PA, self-efficacy, strength of religious faith, and acculturation.

Screening of microRNAs controlling body fat in Drosophila melanogaster and identification of miR-969 and its target, Gr47b.

MicroRNAs (miRNAs) are small non-protein coding RNAs and post-transcriptionally regulate cellular gene expression. In animal development, miRNAs play essential roles such as stem cell maintenance, organogenesis, and apoptosis. Using gain-of-function (GOF) screening with 160 miRNA lines in Drosophila melanogaster, we identified a set of miRNAs which regulates body fat contents and named them microCATs (microRNAs Controlling Adipose Tissue).

ER Stress Activates the TOR Pathway through Atf6.

Cellular signaling pathways are often interconnected. They accurately and efficiently regulate essential cell functions such as protein synthesis, cell growth, and survival. The target of rapamycin (TOR) signaling pathway and the endoplasmic reticulum (ER) stress response pathway regulate similar cellular processes.

Concept Inventory Development Reveals Common Student Misconceptions about Microbiology.

Misconceptions, or alternative conceptions, are incorrect understandings that students have incorporated into their prior knowledge. The goal of this study was the identification of misconceptions in microbiology held by undergraduate students upon entry into an introductory, general microbiology course. This work was the first step in developing a microbiology concept inventory based on the American Society for Microbiology's Recommended Curriculum Guidelines for Undergraduate Microbiology.

Development, Validation, and Application of the Microbiology Concept Inventory.

If we are to teach effectively, tools are needed to measure student learning. A widely used method for quickly measuring student understanding of core concepts in a discipline is the concept inventory (CI). Using the American Society for Microbiology Curriculum Guidelines (ASMCG) for microbiology, faculty from 11 academic institutions created and validated a new microbiology concept inventory (MCI).

Effects of urbanization on the population structure of freshwater turtles across the United States.

Landscape-scale alterations that accompany urbanization may negatively affect the population structure of wildlife species such as freshwater turtles. Changes to nesting sites and higher mortality rates due to vehicular collisions and increased predator populations may particularly affect immature turtles and mature female turtles. We hypothesized that the proportions of adult female and immature turtles in a population will negatively correlate with landscape urbanization.

Link between Monitoring Behavior and Adolescent Adjustment: An Analysis of Direct and Indirect Effects.

The purpose of the current investigation was to explore whether monitoring behavior (i.e., parental solicitation, child disclosure, and parental involvement) was directly and indirectly (via parental knowledge and parent-youth openness) related to adolescent adjustment (i.

Extravasation management of nonchemotherapeutic medications.

Many who think of vesicants think of chemotherapy and oncology patients. But not all vesicants are chemotherapy medications. This article reviews the factors that increase the risk of extravasation, the nonchemotherapeutic medications associated with extravasation injuries, and the recommended treatments.

Psychological reactance: examination across age, ethnicity, and gender.

Psychological reactance is a motivational state aroused when real or perceived personal freedoms are threatened, reduced, or eliminated. Although psychological reactance theory has existed for almost 40 years, there is still dissent over some of its most basic characteristics. Research on age and ethnicity is scant, and research on gender has not produced a clear pattern of results.

Violence in Native America: a historical perspective.

This article is meant to provide an overview of common Native American values and the effect of the imposition of non-Native American belief systems on our communities. The article uses common abusive tactics employed by batterers and juxtaposes these tactics with a historical overview of the dominant culture's treatment of native cultures. This material serves as an outline to examine one's own community, tribe, or nation to gain a greater understanding of how society has traveled to this place and where the social order goes from here.