59 results match your criteria: "Robert-Bosch-Hospital Stuttgart[Affiliation]"

Article Synopsis
  • Coronary functional disorders (CFD) significantly contribute to angina in patients with non-obstructed coronary arteries (ANOCA), with different endotypes identified, such as microvascular spasm and coronary microvascular dysfunction (CMD).
  • A study involving 89 ANOCA patients using comprehensive coronary functional testing (CFT) found that 91% had at least one disorder, with microvascular spasm being the most common (61%).
  • The results highlighted that isolated CMD is rare and emphasized the necessity of spasm testing for diagnosing and characterizing CFD in ANOCA patients.
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Introduction: Men are generally more susceptible to bacterial infections than women. Central venous catheters (CVCs), often used to administer systemic treatment in patients with cancer, are an important source of infection. However, little is known about sex-specific differences of CVC-related bloodstream infections (CRBSIs) in patients with cancer.

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Article Synopsis
  • The European LeukemiaNet (ELN) updated its risk classification for acute myeloid leukemia (AML) patients in 2022 (ELN22) and a study evaluated its effectiveness on 1,570 newly diagnosed patients.
  • Compared to the previous 2017 classification (ELN17), the new ELN22 showed a similar distribution of risk categories but reclassified 22% of patients, mostly into intermediate or adverse groups, resulting in better prognostic accuracy, particularly for overall survival (OS).
  • The study found significant differences in survival rates based on specific gene mutations within the adverse risk group, highlighting the need for tailored treatment approaches based on genetic factors.
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Communication and support of patients and caregivers in chronic cancer care: ESMO Clinical Practice Guideline.

ESMO Open

July 2024

Palliative Medicine, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Universita' degli Studi di Brescia, Brescia, Italy.

• ESMO Clinical Practice Guideline with key recommendations for communication and support of cancer patients and caregivers. • The guideline discusses training in communication of oncology clinicians and research on communication in cancer care. • Practical recommendations aim to support oncology clinicians in their communication with patients and caregivers.

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The impact of MICB mismatches in unrelated haematopoietic stem cell transplantation.

HLA

June 2024

Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, Ulm, and University Hospital Ulm, Ulm, Germany.

Article Synopsis
  • MICA polymorphisms are linked to higher rates of acute GvHD and poor outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), with MICB's role still being unclear.
  • Researchers analyzed a large cohort for MICB polymorphisms, assessing how MICB matching affects outcomes after unrelated HSCT, finding that 69.2% were 10/10 HLA matched.
  • In the 9/10 HLA matched group, MICB mismatches led to worse disease-free survival and relapse-free survival, while MICA mismatches did not significantly impact outcomes, suggesting MICB typing might aid in donor selection among 9/10 matched donors.
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Aims: Intrahepatic cholangiocarcinoma (iCCA) is a diagnosis of exclusion that can pose a challenge to the pathologist despite thorough clinical workup. Although several immunohistochemical markers have been proposed for iCCA, none of them reached clinical practice. We here assessed the combined usage of two promising diagnostic approaches, albumin in situ hybridisation (Alb-ISH) and C reactive protein (CRP) immunohistochemistry, for distinguishing iCCA from other adenocarcinoma primaries.

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Article Synopsis
  • In newly diagnosed acute myeloid leukemia (AML), immediate treatment is typical; however, sometimes treatment may be delayed to evaluate other health issues or risks.
  • A study analyzed the effects of the timing of treatment initiation on outcomes for patients receiving venetoclax-based therapy, comparing two patient groups with average ages of 76 and 72.
  • Results showed no significant difference in overall survival or complications (like severe infections) between those who started treatment within 10 days versus later, suggesting that delaying therapy may be safe for certain patients with proper monitoring.
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Lung Cancer Related Thrombosis (LCART): Focus on Immune Checkpoint Blockade.

Cancers (Basel)

January 2024

Third Department of Internal Medicine and Laboratory, Athens Medical School, National and Kapodistrian University of Athens, Sotiria General Hospital, 157 72 Athens, Greece.

Article Synopsis
  • - Cancer-associated thrombosis (CAT) is a significant issue among lung cancer patients, increasing their risk of thrombosis compared to other cancers and potentially heightened by new treatments like immunotherapy and targeted therapies.
  • - Various risk-assessment models, such as the Khorana Risk Score, have been developed to evaluate thrombosis risk in lung cancer patients, considering factors like genetics and cancer stage.
  • - Management of CAT is guided by extensive trials showing effective use of anticoagulants like low-molecular-weight heparins and direct oral anticoagulants, with treatment tailored to individual patient factors and also impacted by the COVID-19 pandemic.
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Objective: To explore workload-related stress levels experienced by consultation liaison psychiatry (CLP) staff in England and Ireland, and factors relevant to such a burden, during the COVID-19 pandemic.

Methods: Data were obtained for England and Ireland from a European survey among CLP services in general hospitals spread via CLP networks (11th June - 3rd October 2021). The heads of respective CLP services in general hospitals responded on behalf of each service, on 100 CLP hospital staff in total.

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Background: Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are markers of tubular stress and urinary [TIMP-2]*[IGFBP7] is an established biomarker for risk assessment of acute kidney injury. There are no studies of expression profiles or localization of these markers in human renal tissue with confirmed renal disease.

Methods: We analysed 37 kidney biopsies of patients with renal disease and 10 non-diseased control biopsies for TIMP-2 and IGFBP7 expression using immunohistochemistry.

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Aortic Valve Repair Results in Better 1-Year Survival Than Replacement: Results From German Aortic Valve Registry.

Ann Thorac Surg

March 2024

Clinic for Thoracic and Cardiovascular Surgery, Herz-und Diabeteszentrum Bad Oeynhausen, Bad Oeynhausen, Germany.

Background: Aortic valve (AV) repair is an evolving surgical strategy in the treatment of nonelderly adults with aortic regurgitation. We aimed to determine the 1-year outcome after AV repair vs surgical AV replacement (sAVR) using real-world data from the German Aortic Valve Registry.

Methods: A total of 8076 aortic regurgitation patients (mean age, 59.

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The Importance of Thioredoxin-1 in Health and Disease.

Antioxidants (Basel)

May 2023

Department of Internal Medicine and Nephrology, Robert-Bosch-Hospital Stuttgart, 70376 Stuttgart, Germany.

Thioredoxin-1 (Trx-1) is a multifunctional protein ubiquitously found in the human body. Trx-1 plays an important role in various cellular functions such as maintenance of redox homeostasis, proliferation, and DNA synthesis, but also modulation of transcription factors and control of cell death. Thus, Trx-1 is one of the most important proteins for proper cell and organ function.

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Background: An effective therapy of persistent atrial fibrillation beyond pulmonary vein isolation remains unsatisfactory. Targeting endocardial low-voltage areas represents an approach of substrate modification. This prospective, randomized study investigated the efficacy of ablation of low-voltage areas versus PVI and additional linear ablations in patients with persistent atrial fibrillation in terms of single-procedure arrhythmia-free outcome and safety.

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Video 1Case description and video in cholangioscopic view demonstrating bile duct tissue acquisition by cholangioscopy-guided cryobiopsy technique.

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Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia.

Haematologica

August 2023

NCT Trial Center, National Center of Tumor Diseases, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg.

We retrospectively studied 97 acute myeloid leukemia patients with trisomy 19 (median age at diagnosis 57 years; range, 17- 83 years) treated between 2001 and 2019 within two multicenter study groups. Trisomy 19 occurred alone in ten (10.5%) patients, with additional abnormalities being present in non-complex karyotypes in eight (8%) patients and in complex karyotypes in 79 (82%) patients.

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Surgical atrial appendage closure: time for a randomized study.

Herzschrittmacherther Elektrophysiol

December 2022

Department of Cardiovascular Surgery, Robert Bosch Hospital Stuttgart, Auerbachstraße 110, 70376, Stuttgart, Germany.

Atrial fibrillation (AF) is the most common arrhythmia and is assumed to affect more than 30 million people worldwide. Studies report that the left atrial appendage (LAA) plays an important role in thrombus formation and is considered the embolic source in 90% of affected patients with non-valvular and 57% with valvular AF. Oral anticoagulants have been the standard of care for stroke prevention in patients with AF for decades.

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Donor genetic determinant of thymopoiesis rs2204985 impacts clinical outcome after single HLA mismatched hematopoietic stem cell transplantation.

Bone Marrow Transplant

October 2022

Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg-Hessen, Ulm, and University Hospital, Ulm, Germany.

A common genetic variant within the T cell receptor alpha (TCRA)-T cell receptor delta (TCRD) locus (rs2204985) has been recently found to associate with thymic function. Aim of this study was to investigate the potential impact of donor rs2204985 genotype on patient's outcome after unrelated hematopoietic stem cell transplantation (uHSCT). 2016 adult patients were retrospectively analyzed.

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Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4.

Haematologica

January 2023

NCT Trial Center, National Center of Tumor Diseases, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg.

We retrospectively studied 125 patients with acute myeloid leukemia and trisomy 4 (median age at diagnosis, 58 years; range, 16-77 years) treated between 2000 and 2019 within a multicenter study. Trisomy 4 was the sole abnormality in 28 (22%) patients and additional abnormalities were present in 97 (78%) patients. Twenty-two (22%) and 15 (15%) of 101 tested patients harbored NPM1 and FLT3-ITD mutations.

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Background: The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) vary between 80% and 90%. This prospective, randomized study investigated the efficacy of cryoballoon PVI (CBA) versus PVI with radio-frequency (RF)-energy following the CLOSE protocol (ablation index [AI], interlesion distance ≤6 mm, surround flow catheter) in terms of single-procedure arrhythmia-free outcome and safety.

Methods And Results: A total number of 150 patients undergoing de novo catheter ablation for paroxysmal AF were randomized to two different treatment arms.

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Background: Heat waves are known to cause increased morbidity and mortality in susceptible populations like old and functionally impaired people. The objective of the study was to assess renal tubular stress, a predictor for development of acute kidney injury, during heat waves in Central Europe. As a marker of renal tubular stress tissue inhibitor of metalloproteinases-2 [TIMP-2]·insulin-like growth factor binding protein-7 [IGFBP7], a new FDA-cleared renal tubular stress biomarker, was used.

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Under-recognition of Acute Kidney Injury after Cardiac Surgery in the ICU Impedes Early Detection and Prevention.

Kidney Blood Press Res

February 2022

Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany.

Background: Acute kidney injury (AKI) is associated with high morbidity and mortality; therefore, prevention is important. The aim of this study was to systematically assess AKI incidence after cardiac surgery as documented in clinical routine compared to the real incidence because AKI may be under-recognized in clinical practice. Further, its postoperative management was compared to Kidney Disease: Improving Global Outcomes (KDIGO) recommendations because recognition and adequate treatment represent the fundamental cornerstone in the prevention and management of AKI.

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Background: Overall survival remains poor in older patients with acute myeloid leukemia (AML) with less than 10% being alive after 5 years. In recent studies, a significant improvement in event-free, relapse-free and overall survival was shown by adding gemtuzumab ozogamicin (GO), a humanized antibody-drug conjugate directed against CD33, to intensive induction therapy once or in a sequential dosing schedule. Glasdegib, the small-molecule inhibitor of smoothened (SMO), also showed improved overall survival in patients not eligible for intensive chemotherapy when combined with low-dose cytarabine compared to low-dose cytarabine alone.

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Background: The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) varies between 80 and 90%. Ablation index, incorporating contact force, stability, time and power is a more profound parameter of significant lesion size and has been established. Equally important is a stringent contiguity of the lesion set.

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The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis.

Front Immunol

June 2021

Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg-Hessen, and University Hospital Ulm, Ulm, Germany.

T-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts. We retrospectively genotyped HLA-DPB1 in 3523 patients transplanted in Germany between 2000 and 2014 and in their unrelated donors using an Illumina amplicon-NGS based assay.

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