176 results match your criteria: "Robert Debré University Hospital Center[Affiliation]"
Cardiogenic shock in patients with active onco-hematological malignancies: A multicenter retrospective study.
J Crit Care
January 2025
Hospital Saint-Louis et Université Paris Cité, Assistance Publique-Hôpitaux de Paris, France. Electronic address:
Purpose: Onco-hematological (OH) patients face significant cardiovascular risks due to malignancy and drug toxicity. Data are limited on the characteristics and outcomes of OH patients with cardiogenic shock (CS) in intensive care units (ICUs).
Methods: This multicenter retrospective study included 214 OH patients with CS across 22 ICUs (2010-2021).
Efficacy of valaciclovir in preventing herpes zoster in patients receiving anifrolumab.
RMD Open
January 2025
Assistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Centre de Référence des maladies auto-immunes et auto-inflammatoires systémiques rares de l'adulte d'Ile-de-France, Centre et Martinique, Service de Médecine Interne 2, Institut E3M, Paris, France, paris, France.
Associations between PIK3CA Mutations and Disease Free Survival in Patients with HR+, HER2- Tumors Treated with Adjuvant Hormonal Therapy: A Real-World Study in Croatia.
Breast J
January 2025
Department of Oncology University Hospital Center Split School of Medicine University of Split, Split, Croatia.
Article Synopsis
- The study focuses on the challenges of managing disease recurrence in early-stage hormone receptor-positive (HR+), HER2-negative breast cancer due to its biological complexity and the presence of PIK3CA mutations.
- Approximately 30-40% of advanced HR+/HER2- breast cancer patients have PIK3CA mutations, which are linked to poor prognosis by activating pathways that promote cell growth.
- The research found that patients with the PIK3CA mutation, particularly the H1047 variant, had a lower risk of disease recurrence compared to those without the mutation, suggesting its potential as a biomarker for personalized treatment strategies.
Heterozygous UBR5 variants result in a neurodevelopmental syndrome with developmental delay, autism, and intellectual disability.
Am J Hum Genet
January 2025
Department of Genetics, CHU Sainte-Justine, Montréal, QC, Canada. Electronic address:
E3 ubiquitin ligases have been linked to developmental diseases including autism, Angelman syndrome (UBE3A), and Johanson-Blizzard syndrome (JBS) (UBR1). Here, we report variants in the E3 ligase UBR5 in 29 individuals presenting with a neurodevelopmental syndrome that includes developmental delay, autism, intellectual disability, epilepsy, movement disorders, and/or genital anomalies. Their phenotype is distinct from JBS due to the absence of exocrine pancreatic insufficiency and the presence of autism, epilepsy, and, in some probands, a movement disorder.
View Article and Find Full Text PDFImpact of the Acti-Pair programme on physical activity in patients with prostate cancer: protocol of the Acti-Pair 2 stepped-wedge cluster randomised trial.
BMJ Open Sport Exerc Med
December 2024
U1059 INSERM, SAINBIOSE, DVH, Lyon University, Jean Monnet University, Saint-Etienne, France.
Regular physical activity (PA) reduces morbidity and mortality in prostate cancer. Prescribing PA in cancer is a necessary awareness but is a real challenge in the case of prostate cancer. Motivational peer support seems to be an innovative strategy for lifestyle change.
View Article and Find Full Text PDFSwitching From Dupilumab to Tralokinumab or Janus Kinase Inhibitors in Cases of Ocular and/or Facial Adverse Events in Patients With Atopic Dermatitis: A Multicenter Retrospective Study.
J Allergy Clin Immunol Pract
December 2024
Department of Dermatology, University Hospital of Nice, Côte d'Azur University, Nice, France. Electronic address:
Background: Patients with atopic dermatitis (AD) may discontinue dupilumab owing to dupilumab-induced ocular adverse events (DOAEs) or dupilumab-induced facial redness (DFR).
Objective: To evaluate DOAE and DFR outcomes after switching to tralokinumab or Janus kinase inhibitor (JAKi).
Methods: This retrospective study included 106 patients discontinuing dupilumab because of DOAEs and/or DFR.
2q33 Deletions Underlying Syndromic and Non-syndromic CTLA4 Deficiency.
J Clin Immunol
November 2024
Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, EU, France.
Purpose: CTLA4 deficiency is an inborn error of immunity (IEI) due to heterozygosity for germline loss-of-function variants of the CTLA4 gene located on chromosome 2q33.2. CTLA4 deficiency underlies pleiotropic immune and lymphoproliferation-mediated features with incomplete penetrance.
View Article and Find Full Text PDFDefining standards for fluoroscopy in gastrointestinal endoscopy using Delphi methodology.
Endosc Int Open
November 2024
Division of Gastroenterology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- The study focuses on developing guidelines for the safe use of fluoroscopy in gastrointestinal endoscopy, balancing its benefits with concerns about radiation exposure to patients and healthcare workers.
- A modified Delphi method was used, involving three rounds of surveys with 46 experts, resulting in 43 proposed statements, of which 31 achieved consensus and were prioritized across various categories such as Patient Safety and Staff Safety.
- The final consensus statements highlight the importance of education and safety measures, with a significant majority rated as high priority, aiming to enhance safety culture in healthcare settings while utilizing fluoroscopy.
Risk of Incident Cancer in Patients with Inflammatory Bowel Disease with Prior Breast Cancer: A Multicenter Cohort Study.
Clin Gastroenterol Hepatol
November 2024
Department of Gastroenterology, Bicêtre University Hospital, AP-HP, Universite Paris Saclay, INSERM CESP, Le Kremlin Bicêtre, Le Kremlin Bicêtre, France.
Background & Aims: Breast cancer is the most common malignancy observed in patients with inflammatory bowel diseases (IBD). The aim of our study was to evaluate incident cancer rate (recurrence or new-onset cancer) in a cohort of patients with IBD with a history of breast cancer according to the subsequent IBD treatment provided.
Methods: A multicenter retrospective study included consecutive patients with IBD with prior breast cancer.
Recommendations from the French Societies of Rheumatology and Physical Medicine and Rehabilitation on the non-pharmacological management of knee osteoarthritis.
Ann Phys Rehabil Med
October 2024
Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hopitaux de Paris, Sorbonne Université, Inserm UMRS_938, FHU PaCeMM Paris, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France. Electronic address:
Article Synopsis
- - The French Society of Rheumatology and the French Society of Physical Medicine and Rehabilitation aimed to create recommendations for non-drug treatments for knee osteoarthritis due to their inadequate consideration in care.
- - A systematic review of literature was conducted, followed by discussions among experts to draft and evaluate a list of recommendations for managing knee OA non-pharmacologically.
- - Five key principles were established, emphasizing a combination of treatments, personalized management, adherence, appropriate exercise, and education, alongside specific recommendations for 11 modalities like braces, physical therapy, and weight loss.
Article Synopsis
- The study analyzed global, regional, and national trends in injury burden and identified risk factors contributing to injuries using data from the GBD 2019.
- In 2019, there were approximately 713.9 million injury incidents and 4.3 million injury-related deaths globally, with low bone mineral density emerging as the leading risk factor.
- The findings emphasize the need for effective global injury prevention policies by highlighting the persistent impact of injuries on global health.
Sex dependence of postoperative pulmonary complications - A post hoc unmatched and matched analysis of LAS VEGAS.
J Clin Anesth
December 2024
Amsterdam University Medical Center, Department of Anaesthesiology, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands; Amsterdam University Medical Center, Department of Intensive Care, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.
Article Synopsis
- The study aimed to investigate whether there are differences in postoperative pulmonary complications (PPCs) between males and females following surgery under general anesthesia, using data from the LAS VEGAS study involving 146 hospitals across 29 countries.
- A total of 9,697 patients were analyzed in two cohorts: an unmatched cohort (55.1% female, 44.9% male) and a matched cohort (50% female and male), finding no significant differences in PPC rates between the genders in both cohorts.
- The study concluded that, in this international patient population, the incidence of PPCs did not differ significantly between males and females, as well as noting comparable hospital stays and mortality rates.*
Association between pertactin-producing Bordetella pertussis and fulminant pertussis in infants: a multicentre study in France, 2008-2019.
Clin Microbiol Infect
February 2025
Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France; National Reference Center for Whooping Cough and Other Bordetella Infections, Institut Pasteur, Paris, France; Department of General Pediatrics and Pediatric Infectious Diseases, Hôpital Necker-Enfants Malades, APHP, Université Paris Cité, Paris, France. Electronic address:
Article Synopsis
- * Researchers analyzed data from 361 infants with confirmed pertussis, finding that 32 (9%) developed fulminant symptoms, which were more common in neonates, unvaccinated, and premature infants.
- * Results indicated that B. pertussis strains that produced PRN were associated with higher risks of fulminant pertussis, suggesting the significance of PRN in the severity of the disease.
Computer-aided diagnosis for the resect-and-discard strategy for colorectal polyps: a systematic review and meta-analysis.
Lancet Gastroenterol Hepatol
November 2024
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Endoscopy Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.
Article Synopsis
- The study explores the use of computer-aided diagnosis (CADx) in the resect-and-discard strategy for the optical diagnosis of diminutive polyps during colonoscopy, aiming to improve diagnosis and reduce unnecessary pathology assessments.
- It involved a systematic review of existing research to analyze the effectiveness of CADx systems compared to traditional histology for small polyps (≤5 mm), including comparisons of CADx-assisted and unassisted methods.
- The meta-analysis included 11 studies with a total of 7400 polyps examined, highlighting the potential benefits and harms of using CADx in terms of accurate diagnosis and avoidance of false positives/negatives.
Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists.
Endocrine
January 2025
Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Article Synopsis
- An online survey of European thyroid specialists revealed that 28% believe thyroid hormone (TH) treatment may be appropriate for euthyroid patients with growing simple goiters, despite guidelines against this practice.
- There were significant regional differences in support for TH treatment, with only 7% in The Netherlands compared to 78% in the Czech Republic.
- Factors influencing the likelihood of recommending TH included the specialist's age and the historical iodine insufficiency of their region, while gender, country, and economic factors showed weak associations.
Massive hemoptysis: A normal platelet count may not be enough.
Respir Med Res
November 2024
Hematology Department, European Hospital Georges-Pompidou, Paris, France; Paris Cité University, INSERM, Innovative Therapies in Haemostasis, Paris, France.
Survival and Prognostic Factors After Adrenalectomy for Secondary Malignancy: A Combined Analysis of a French University Center Registry (Eurocrine) of 307 Patients and a French Nationwide Study of 2515 Patients.
Ann Surg
November 2024
Translational Research Laboratory for Diabetes, General Endocrine Surgery, Lille University Hospital Chu Lille, Lille University, Lille, France.
Article Synopsis
- * A total of 2,515 patients were examined, primarily with lung and renal cancer, revealing a one-year survival rate of 84.3% and low mortality and morbidity rates post-surgery.
- * Findings indicate that while adrenalectomy is increasingly performed minimally invasively, factors like extra-adrenal metastases and incomplete surgery are linked to poorer survival outcomes, highlighting a need for future research on patient selection for this procedure.
Ethnic disparities in mental health problems in New Caledonia and French Polynesia.
Aust N Z J Psychiatry
November 2024
ECEVE, UMR 1123, Inserm, Université Paris Cité, Paris, France.
Objectives: Indigenous people experience poorer mental health compared to the general population. Socioeconomic gaps partly explain these disparities. However, there is variability between populations and French overseas territories are understudied.
View Article and Find Full Text PDFNew studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection.
Inflammopharmacology
October 2024
Department of Pathology, School of Medicine, University of Zagreb, 10000, Zagreb, Croatia.
Article Synopsis
- * Clinical evidence supports BPC 157’s effectiveness in treating various conditions, including ulcerative colitis, with no side effects reported, and it demonstrates a capacity for tissue regeneration across multiple systems such as muscles, tendons, and the heart.
- * The review discusses BPC 157's role in counteracting severe complications from major vessel failures and various organ system disturbances, emphasizing its use in conditions linked to alcohol-induced stomach lesions and overall vascular recovery.
Automatic gross tumor volume segmentation with failure detection for safe implementation in locally advanced cervical cancer.
Phys Imaging Radiat Oncol
April 2024
Université Paris-Saclay, Institut Gustave Roussy, Inserm, Radiothérapie Moléculaire et Innovation Thérapeutique, 94800 Villejuif, France.
Article Synopsis
- This study compares various Deep Learning models for segmenting Gross Tumor Volume (GTV) in patients with locally advanced cervical cancer, emphasizing the need for improved segmentation methods in Radiotherapy.
- Eight different models were trained using both 2D and 3D segmentation techniques, with the 2D-SegResNet model performing the best, achieving a high level of segmentation accuracy.
- Additionally, a novel failure detection system using radiomic features was introduced, potentially aiding doctors in identifying segmentation errors and enhancing overall treatment planning.
Effects of tumor treating fields (TTFields) on human mesenchymal stromal cells.
J Neurooncol
September 2024
Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), partner site DKTK-Freiburg, Robert-Koch-Str. 3, 79106, Freiburg, Germany.
Purpose: Mesenchymal stromal cells (MSCs) within the glioblastoma microenvironment have been shown to promote tumor progression. Tumor Treating Fields (TTFields) are alternating electric fields with low intensity and intermediate frequency that exhibit anti-tumorigenic effects. While the effects of TTFields on glioblastoma cells have been studied previously, nothing is known about the influence of TTFields on MSCs.
View Article and Find Full Text PDFTreatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration.
J Endocrinol Invest
January 2025
Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Purpose: The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as reflected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European thyroid specialists.
Methods: Specialists from 28 countries were invited to a survey via professional organisations.
Use of levothyroxine for euthyroid, thyroid antibody positive women with infertility: Analyses of aggregate data from a survey of European thyroid specialists (Treatment of Hypothyroidism in Europe by Specialists: An International Survey).
Clin Endocrinol (Oxf)
August 2024
Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.
Article Synopsis
- - The study aimed to assess how European thyroid specialists view levothyroxine (LT4) treatment for euthyroid women with positive thyroid peroxidase antibodies (TPOAb) to improve fertility, as current evidence does not support this practice.
- - An international survey (THESIS) revealed that 42.8% of over 2,316 respondents believe LT4 might be indicated for these patients, with significant variation across countries, highlighting a range from 22.9% to 83.7% of positive responses.
- - Factors such as gender, age, and clinical experience influenced opinions; younger specialists and those who treat more thyroid patients were more likely to consider LT4, raising concerns about potential overtreatment risks in