Glomerular filtration and volume regulation in gravid animal models.

The gestational increase in glomerular filtration rate that occurs in the normal rat is exclusively the result of an increase in renal plasma flow and there is no sustained increase in glomerular capillary blood pressure during a normal pregnancy. The factor or factors that initiate the gestational renal vasodilatation (and plasma volume expansion) are maternal, not fetoplacental in origin. The precise nature of the initiating factors has not yet been defined, although it is unlikely that the gestational plasma volume expansion can be the sole cause of the increased glomerular filtration rate seen in pregnancy.