9,756 results match your criteria: "Rikshospitalet.[Affiliation]"

Background: Fontan circulatory failure with impaired systolic function is well documented; however, its mechanisms are not fully understood. We aimed to explore the myocardial functional reserve in adolescent patients with Fontan circulation in response to exercise or acute preload increase.

Methods: Our study comprised 32 patients (median age: 16.

View Article and Find Full Text PDF

The gut microbiota influences multiple aspects of human health and disease. Several studies have indicated an association between the gut microbiota and response to immune checkpoint inhibitors in various cancers, but there is scarce data from breast cancer. The randomized ALICE trial demonstrated improved progression-free survival (PFS) from adding the programmed cell death 1 ligand 1 (PD-L1) inhibitor atezolizumab (atezo) to immunomodulating chemotherapy (chemo) in metastatic triple-negative breast cancer (mTNBC), even for PD-L1 disease.

View Article and Find Full Text PDF

Background And Aims: Familial hypercholesterolemia (FH) is an inherited disease associated with hypercholesterolemia, and dietary treatment is part of the treatment. We aimed to assess the dietary pattern in relation to the Healthy Nordic Food Index (HNFI) in adults with and without heterozygous FH (HeFH), and to examine the associations between dietary quality and biomarkers related to cardiovascular disease in adults with HeFH.

Methods: We included 205 adults (≥18 years) with HeFH who received follow-up at the Lipid Clinic in Oslo and compared them to controls (n = 228).

View Article and Find Full Text PDF

The 12th international workshop on the CCN family of genes took place at the Scandic Holmenkollen Park Hotel in Oslo, Norway from June 20-23, 2024. In 2024, it was the second time, following the Nice meeting in 2022, that the scientific topics were expanded to include additional cellular signaling and communication pathways of interest to the CCN Society members, as suggested by Bernard Perbal in 2019. The 12th international CCN workshop, organized by Håvard Attramadal and Vivi T.

View Article and Find Full Text PDF

Background: There is an unmet need for treatment of long-term symptoms following COVID-19. Remdesivir is currently the only antiviral approved by the European Medicines Agency for hospitalised patients. Here, we report on the effect of remdesivir in addition to standard of care on long-term symptoms and quality of life in hospitalised patients with COVID-19 as part of the open-label randomised NOR-Solidarity trial (NCT04321616).

View Article and Find Full Text PDF

Background: Speckle tracking echocardiography (STE) provides quantification of left ventricular (LV) deformation and is useful in the assessment of LV function. STE is increasingly being used clinically, and every effort to simplify and standardize STE is important. Manual outlining of regions of interest (ROIs) is labor intensive and may influence assessment of strain values.

View Article and Find Full Text PDF

Background: Several reports exist of an acquired exercise-induced arrhythmogenic cardiomyopathy. Little is known about myocardial disease progression and arrhythmia prediction in this population.

Objective: The study sought to explore the evolution of myocardial function and structure and its relation to incident life-threatening ventricular arrhythmias (VA), to identify markers of impending events.

View Article and Find Full Text PDF

Background: Patients with PAX3/7-FOXO1 fusion-negative rhabdomyosarcomas (fnRMS) harbouring the rare L122R MYOD1 mutation have significantly poorer prognosis than other fnRMS. We undertook a detailed clinicopathological evaluation of a cohort of patients with MYOD1 mutated fnRMS in order to improve risk stratification and treatment options.

Procedure: Histological, mutational and clinical data from a cohort of patients with MYOD1 mutant RMS treated in Europe were analysed.

View Article and Find Full Text PDF

Newborn screening for SCID and severe T lymphocytopenia in Europe.

J Allergy Clin Immunol

November 2024

Laboratory for Paediatric Immunology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Article Synopsis
  • Newborn screening (NBS) programs in Europe started in the 1960s, expanding recently to include testing for severe combined immunodeficiency (SCID) through T-cell receptor excision circles (TRECs).
  • A survey sent to 46 European countries collected comprehensive data, with 38 countries responding, revealing that 17 have already implemented TREC-based NBS.
  • The findings indicate a need to reassess the definition of the target disease to include conditions beyond SCID and highlight the importance of international collaboration for improving universal TREC-based screening.
View Article and Find Full Text PDF
Article Synopsis
  • - The text discusses the development of updated recommendations for diagnosing and treating polymyalgia rheumatica (PMR) by a working group within the Norwegian Society of Rheumatology.
  • - They conducted a narrative review of existing evidence and integrated guidelines from various organizations, including EULAR and ACR, to ensure consistency.
  • - The final output includes 10 specific recommendations focusing on diagnosis, treatment, and follow-up care for PMR patients to enhance their management and health outcomes.
View Article and Find Full Text PDF

Gut dysbiosis and neutrophil extracellular traps in chronic heart failure.

Int J Cardiol

January 2025

Oslo Center for Clinical Heart Research, Department of Cardiology Ullevaal, Oslo University Hospital, Oslo, Norway; Department of Cardiology Ullevaal, Oslo University Hospital, Oslo, Norway.

Background: Chronic heart failure (HF) patients have reduced microbiota diversity. Leakage of microbes and their metabolites into the bloodstream may activate neutrophils. Neutrophil extracellular traps (NETs) consist of chromatin and proteases, and may contribute to HF pathogenesis.

View Article and Find Full Text PDF

Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting cells (APCs) that coordinate the adaptive immune response, and which can be classified into different subsets, with specific functions, and markers. In this article, we review current data on the contribution of different DC subsets to TLS function in cancer and autoimmunity, two opposite sides of the immune response.

View Article and Find Full Text PDF

Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder.

Psychiatry Res

December 2024

K.G. Jebsen Center for Neurodevelopmental Disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, building 25, Kirkeveien 166, Oslo 0450, Norway; Department of Clinical Science, NORMENT, University of Bergen, Bergen, Norway. Electronic address:

Background: Evidence suggests dysregulated immune functions in the pathophysiology of Autism spectrum disorder (ASD), although specific immune mechanisms are yet to be identified.

Methods: We assessed circulating levels of 25 immune/neuroinflammatory markers in a large ASD sample (n = 151) and matched controls (n = 72) using linear models. In addition, we performed global brain transcriptomics analyses of relevant immune-related genes.

View Article and Find Full Text PDF

Background: Obstructive sleep apnoea (OSA) can cause left atrial (LA) and left ventricular (LV) remodelling, which is linked to atrial fibrillation (AF). Whether continuous positive airway pressure (CPAP) can reverse LA and LV remodelling in patients with OSA and paroxysmal AF (PAF) has yet to be studied. We assessed the impact of CPAP treatment on LA and LV size and function in patients with OSA and PAF before and after catheter ablation.

View Article and Find Full Text PDF

Introduction: This report presents a case of an exceptionally delayed distant recurrence of a choroidal melanoma, occurring 4 decades after the enucleation of the affected eye.

Case Presentation: In 1977, a 29-year-old man underwent enucleation for a choroidal melanoma. At the age of 68 years, he was diagnosed with advanced prostate cancer.

View Article and Find Full Text PDF

Background: Pulmonary endarterectomy (PEA) is the treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH), while balloon pulmonary angioplasty (BPA) is an alternative for inoperable patients. We aimed to compare right ventricular (RV) remodelling and late survival after PEA and BPA.

Methods: In this prospective observational cohort study, we performed echocardiography at baseline and follow-up in patients with CTEPH treated with PEA (n=54) or BPA (n=44) between 2011 and 2022.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the reproducibility of regional longitudinal strain (RLS) measurements in echocardiograms, particularly focusing on a new deep learning (DL) method for measuring RLS.
  • It found that the DL method significantly improved reproducibility (33-35% better) compared to traditional methods used by experienced observers, with a minimal detectable change (MDC) of 3.6 to 4.3%.
  • The DL method also demonstrated high feasibility and efficiency, allowing for quick measurements (1 second per echocardiogram), potentially enhancing patient care through more reliable assessments of heart function.
View Article and Find Full Text PDF

The risk of sudden cardiac death (SCD) is increased during endurance competitive sports. Coronary artery disease (CAD) is the most common cause of SCD in master athletes ≥ 35 years old (MAs). To reduce the risk of SCD self-assessment of symptoms by questionnaire, and evaluation of cardiovascular risk-score, are recommended as pre-participation cardiovascular evaluation (PCVE).

View Article and Find Full Text PDF

Objective: The objective of this study is to assess associations between pregnancy complications and pregnancy-associated maternal mortality (PAM) within 1 year after childbirth.

Design: Population-based cohort study.

Setting: Norway, 1967-2020.

View Article and Find Full Text PDF

Background: Spontaneous subarachnoid hemorrhage (SAH) often results in altered cerebrospinal fluid (CSF) flow and secondary hydrocephalus, yet the mechanisms behind these phenomena remain poorly understood. This study aimed to elucidate the impact of SAH on individual CSF flow patterns and their association with secondary hydrocephalus.

Methods: In patients who had experienced SAH, changes in CSF flow were assessed using cardiac-gated phase-contrast magnetic resonance imaging (PC-MRI) at the Sylvian aqueduct and cranio-cervical junction (CCJ).

View Article and Find Full Text PDF

Adaptive immune receptors, such as antibodies and T-cell receptors, recognize foreign threats with exquisite specificity. A major challenge in adaptive immunology is discovering the rules governing immune receptor-antigen binding in order to predict the antigen binding status of previously unseen immune receptors. Many studies assume that the antigen binding status of an immune receptor may be determined by the presence of a short motif in the complementarity determining region 3 (CDR3), disregarding other amino acids.

View Article and Find Full Text PDF

Left atrial volume assessed by echocardiography identifies patients with high risk of adverse outcome after acute myocardial infarction.

Echo Res Pract

October 2024

ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet Sognsvannsveien 20, Nydalen, PO Box 4950, Oslo, NO-0424, Norway.

Background: The left atrial (LA) volume has been demonstrated to be an important predictor of adverse outcome in patients with various cardiac conditions, including acute myocardial infarction (AMI). However, new treatment strategies in patients with AMI have led to better patient outcomes. We hypothesised that increased LA size could still predict mortality in patients with AMI despite improved treatment strategies.

View Article and Find Full Text PDF

Background: The aim of this study was to assess whether hypothermia increased survival and improved functional outcome when compared with normothermia in out-of-hospital cardiac arrest (OHCA) patients with similar characteristics than in previous randomized studies showing benefits for hypothermia.

Methods: Post hoc analysis of a pragmatic, multicenter, randomized clinical trial (TTM-2, NCT02908308). In this analysis, the subset of patients included in the trial who had similar characteristics to patients included in one previous randomized trial and randomized to hypothermia at 33 °C or normothermia (i.

View Article and Find Full Text PDF

[Not Available].

Tidsskr Nor Laegeforen

October 2024

Avdeling for kreftbehandling, Oslo universitetssykehus, Radiumhospitalet.

Breast cancer is the most commonly occurring form of cancer in pregnancy. Among women aged between 25 and 29 years, one in five cases of breast cancer will occur in pregnancy or during the first postnatal year. The prevalence is increasing, presumably because of the increase in maternal age at pregnancy.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to compare immune responses to a COVID-19 booster vaccination between older adults and younger individuals, focusing on humoral and cellular immunity.
  • Researchers found that older adults (average age 86) initially had lower immune responses after earlier vaccinations compared to younger adults (average age 39), but both groups improved their antibody levels after the booster.
  • While young adults showed increased cellular immune responses after the booster, older adults did not, and their plasma showed higher levels of certain T cell activation and exhaustion markers, indicating potential immune dysfunction in the elderly.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: